Sentences with phrase «failure risk factors»
Of the three heart - failure risk factors cited, diabetes appeared to have the greatest effect.
http://www.health.com/ Not exact matches
Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.
Such factors include, among others, general business, economic, competitive, political and social uncertainties; the actual results of current and future exploration activities; the actual results of reclamation activities; conclusions of economic evaluations; meeting various expected cost estimates; changes in project parameters and / or economic assessments as plans continue to be refined; future prices of metals; possible variations of mineral grade or recovery rates; the risk that actual costs may exceed estimated costs; failure of plant, equipment or processes to operate as anticipated; accidents, labour disputes and other risks of the mining industry; political instability; delays in obtaining governmental approvals or financing or in the completion of development or construction activities, as well as those factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15factors include, among others, general business, economic, competitive, political and social uncertainties; the actual results of current and future exploration activities; the actual results of reclamation activities; conclusions of economic evaluations; meeting various expected cost estimates; changes in project parameters and / or economic assessments as plans continue to be refined; future prices of metals; possible variations of mineral grade or recovery rates; the risk that actual costs may exceed estimated costs; failure of plant, equipment or processes to operate as anticipated; accidents, labour disputes and other risks of the mining industry; political instability; delays in obtaining governmental approvals or financing or in the completion of development or construction activities, as well as those factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2risk that actual costs may exceed estimated costs; failure of plant, equipment or processes to operate as anticipated; accidents, labour disputes and other risks of the mining industry; political instability; delays in obtaining governmental approvals or financing or in the completion of development or construction activities, as well as those factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2018.
Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sfactors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sfactors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sFactors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.
That number needn't be so low, as many carriers offer online programs to help identify risk factors for common chronic diseases (e.g.: diabetes, congestive heart failure, asthma, obesity, cancer) and offer prevention programs.
Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.
Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, increased competition; the Company's ability to maintain, extend and expand its reputation and brand image; the Company's ability to differentiate its products from other brands; the consolidation of retail customers; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's inability to realize the anticipated benefits from the Company's cost savings initiatives; changes in relationships with significant customers and suppliers; execution of the Company's international expansion strategy; changes in laws and regulations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; failure to successfully integrate the business and operations of the Company in the expected time frame; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the nations in which the Company operates; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives that the Company uses; exchange rate fluctuations; risks associated with information technology and systems, including service interruptions, misappropriation of data or breaches of security; the Company's inability to protect intellectual property rights; impacts of natural events in the locations in which the Company or its customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; tax law changes or interpretations; and other factors.
These risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal, state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher - than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets; risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or other intellectual property; a possible impairment in the carrying value of our goodwill or other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.
«After adjusting for confounding factors, they found that men who consumed a daily bowl of whole grain (but not refined) cereal had a 29 percent lower risk of heart failure.»
A major risk factor of heart failure is high blood pressure, or hypertension, which is more common among African - Americans.
«Timing of menopause onset may increase heart failure risk in women: Shorter reproductive duration, never giving birth among factors influencing risk.»
The current study used prospectively collected electronic health records to investigate the contemporary incidence and risk factors for heart failure after a first myocardial infarction.
«One in four patients develop heart failure within four years of first heart attack: Risk factors include older age, socioeconomic deprivation, and diabetes.»
High blood pressure is a major risk factor for heart attacks, stroke and heart failure.
One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as difailure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diFailure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diFailure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diabetes.
A number of factors were associated with an increased risk of developing heart failure after a first myocardial infarction.
Dr Gho said: «Previous research looking at all cause heart failure, not only after myocardial infarction, has found similar risk factors.
A high dietary salt intake is linked to high blood pressure, which is a risk factor for stroke, heart attacks, heart failure and kidney disease.
Researchers chose to compare those with and without heart failure after heart attack because these patient groups have a lot in common, including atherosclerosis, risk factors, treatments received and follow - up routines.
«For the future,» she added, «might we match donors and recipients based on genetic factors, or consider fertility preservation for women with a high risk of premature ovarian failure?»
Furthermore, when the authors examined the outcomes individually, the OSA risk factors were associated with increased risk for all - cause mortality, hospitalization for congestive heart failure, and stroke, but not for acute myocardial infarction.
We would however need to know more to identify helpful interventions — for example, is school failure in itself a risk factor, or is poor performance rather an indicator of vulnerability?»
(2) The result is that women's risk factors are left untreated, leaving them more vulnerable to heart attack, heart failure and sudden cardiac death when the protection fades after menopause.»
Several studies over the past decade have shown that a strong emotional shock can lead to sudden heart failure in people with no known risk factors for heart disease.
To measure the impact of physical fitness on heart disease risk factors, the researchers selected 205 men and 44 women with heart disease, including coronary artery disease, stroke, congestive heart failure, and heart valve disease, and had them undergo a cycle ergometer (stationary bike) stress test to determine their fitness level.
The researchers plan to further investigate the data to determine whether the use of medications to control risk factors helps to delay the onset of heart failure.
People who had only one or two of the risk factors, but not all three, developed heart failure an average of three to 11 years earlier than people with none of the risk factors.
This is supported by the recent characterisation of trimethylamine N - oxide (TMAO), a metabolic product of gut bacteria, as an independent risk factor for the mortality rate in patients with heart failure.
«This is significant to stroke care because many stroke risk factors — such as high blood pressure, heart failure, coronary artery disease — are more common in old age.
Lüdde and his colleagues believe it is plausible that an altered bacterial profile could also be a risk factor or an early disease marker for heart failure.
They identified nearly 1,500 cases of heart failure and compared the age at which patients were diagnosed with heart failure against their health status and risk factors at age 45.
Obesity, hypertension and diabetes are known risk factors for heart failure, a chronic condition in which the heart can not pump enough blood to meet the body's needs.
«It's a much more powerful message, when you're talking to patients in their 30s or 40s, to say that they will be able to live 11 to 13 years longer without heart failure if they can avoid developing these three risk factors now.»
«The associations between these risk factors and heart failure has been remarkably stable over time,» Ahmad said.
The death of a partner is linked to a heightened risk of developing an irregular heartbeat otherwise known as atrial fibrillation — itself a risk factor for stroke and heart failure — for up to a year afterwards, finds research published in the online journal Open Heart.
Studies have shown visceral obesity to be a risk factor on its own as well, a strong predictor of, among other things, heart attacks in young men, chronic heart failure in older people, high blood pressure in Japanese Americans, heart attacks in «well functioning» elderly women, and — the clincher, the coup de grease, if you will — of «all - cause mortality» in men.
Additionally, even with heightened risk, a heart healthy lifestyle — maintaining a normal body weight, regular exercise and controlling other risk factors such as high blood pressure, diabetes and high cholesterol — can help lower the risk of heart disease and heart failure.
This is a desirable feature for a helper drug as it would reduce the risk of treatment failure due to factors other than antibiotic resistance (e.g. biofilms, immunosuppression, etc.), allow dose reduction for toxic antibiotics such as colistin, and possibly even prevent selection of resistant mutants» says Guardabassi.
Excessive pressure factored into a 1989 well failure that yielded new clues about the risks of injection.
Obesity, hypertension and diabetes are all important and independent risk factors for heart failure and may cause more adverse impairment of myocardial metabolism in women compared with men (302, 303).
Risk factors for kidney cancer include tobacco use, obesity, high blood pressure, chronic renal failure, exposure to certain industrial chemicals, such as trichloroethylene, and radiation.
Taking into account age and other risk health factors they found that two - thirds of women who undergo fertility therapy never become pregnant, and when compared to the one - third who do conceive, the women who never give birth end up with an increased risk for stroke and heart failure.
«Unlike other heart disease risk factors like high blood pressure or high cholesterol, we don't have specifically effective drugs to prevent heart failure, so we need to identify and verify effective strategies for prevention and emphasize these to the public,» she said.
While anyone who sits for long periods can develop a blood clot, certain factors boost your risk, including obesity, smoking, being pregnant, having heart failure, kidney conditions, a previous clot, cancer, or taking certain medications, such as birth control pills.
«Postprandial Hyperglycaemia as an Eitiological Risk Factor in Vascular Failure,» Cadiovascular Diabetology, 8, 23.
For example, obesity is a known risk factor for surgical delivery.21 Given that failure to progress and CPD are among the top indications for cesarean deliveries in young women under the age of twenty - five, 11 it is discouraging to note that c - section rates for both of these two indications also increase markedly with level of obesity.22
A team of German researchers systematically reviewed all of the published yoga research up until October 2013 to ascertain yoga's effectiveness in reducing «mortality, nonfatal cardiac events, exercise capacity, health - related quality of life, and modifiable cardiac risk factors» for those with a prior diagnosis of coronary artery disease, heart failure, cardiac dysrhythmia, cardiomyopathy or valvular heart disease.
«After adjusting for confounding factors, they found that men who consumed a daily bowl of whole grain (but not refined) cereal had a 29 percent lower risk of heart failure.»
Hypertension is a major risk factor for cardiovascular disease and is associated with substantial morbidity and mortality, estimated to account for 35 % of myocardial infarction and stroke, 49 % of heart failure, and 24 % of premature mortality (42).
The condition is a major risk factor for serious diseases such as peripheral vascular disease, kidney disease, coronary artery disease, stroke and heart failure.