Sentences with phrase «failure risk in»

«Study quantifies kidney failure risk in living kidney donors.»

Sitting for long periods increases heart failure risk in men, even for those who exercise regularly, according to new research published in the American Heart Association journal Circulation: Heart Failure.

«Exercising more, sitting less reduces heart failure risk in men.»

«Blood phosphorus levels can help predict kidney failure risk in African Americans.»

«Timing of menopause onset may increase heart failure risk in women: Shorter reproductive duration, never giving birth among factors influencing risk.»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Eve admits in its prospectus: «The highly competitive nature of this market means that the Company is continually subject to the risk of (a) loss of (or failure to increase) market share, (b) reductions in margins and (c) the inability to secure new customers.»

In a letter, committee chair Damian Collins said Facebook officials had previously misled the lawmakers about risks in the site's data - sharing practices, and said it was «now time to hear from a senior Facebook executive with the sufficient authority to give an accurate account of this catastrophic failure of process.&raquIn a letter, committee chair Damian Collins said Facebook officials had previously misled the lawmakers about risks in the site's data - sharing practices, and said it was «now time to hear from a senior Facebook executive with the sufficient authority to give an accurate account of this catastrophic failure of process.&raquin the site's data - sharing practices, and said it was «now time to hear from a senior Facebook executive with the sufficient authority to give an accurate account of this catastrophic failure of process.»

Such factors include, among others, general business, economic, competitive, political and social uncertainties; the actual results of current and future exploration activities; the actual results of reclamation activities; conclusions of economic evaluations; meeting various expected cost estimates; changes in project parameters and / or economic assessments as plans continue to be refined; future prices of metals; possible variations of mineral grade or recovery rates; the risk that actual costs may exceed estimated costs; failure of plant, equipment or processes to operate as anticipated; accidents, labour disputes and other risks of the mining industry; political instability; delays in obtaining governmental approvals or financing or in the completion of development or construction activities, as well as those factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2risk that actual costs may exceed estimated costs; failure of plant, equipment or processes to operate as anticipated; accidents, labour disputes and other risks of the mining industry; political instability; delays in obtaining governmental approvals or financing or in the completion of development or construction activities, as well as those factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2018.

Risk - taking and failure go hand - in - hand.

Then there is risk aversion due to the fact that «our professional and personal pride is tied up in being right» and because «employees are rewarded for good decisions and penalized for failures.»

Starting a social business presents its own set of challenges, but couple that with the security risks, poor infrastructure and lack of resources found in a disaster area and you have the perfect recipe for failure.

Still, major engine failures in which debris escapes from the turbine's hardened exterior shield remain a risk in aviation that regulators and accident investigators have focused on, Wallace said.

«In business, you have to take calculated risks, have failures and learn from them, and you have to address actual needs of the market — not with a «nice to have,» but a «have to have.»»

And perhaps more importantly, learn from their failures too — because the risk of this happening in our globalized marketplace is only increasing.

Your business will face a bunch of risks that it can't insure against, such as increased competition, declining margins, staff turnover, or the failure of a new product to make a splash in the market.

According to Ralph Heath, managing partner of Synergy Leadership Group and author of Celebrating Failure: The Power of Taking Risks, Making Mistakes, and Thinking Big, failure and defeat are our best teachers, but many people, especially those in conservative corporate cultures, avoid goingFailure: The Power of Taking Risks, Making Mistakes, and Thinking Big, failure and defeat are our best teachers, but many people, especially those in conservative corporate cultures, avoid goingfailure and defeat are our best teachers, but many people, especially those in conservative corporate cultures, avoid going there.

«Gold is stuck between $ 1,238 - $ 1,260 with the risk to skewed to downside based on rising expected interest rates and failure to break higher which has left it vulnerable to profit - taking in the short term,» said Ole Hansen, the head of commodity strategy at Saxo Bank.

In fact, one could argue that capital investments are much more prone to risk and failure, since these costs are fixed rather than variable.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

The new Alzheimer's framework may not be much of a surprise given numerous, high - profile, late - stage clinical trial failures in the field by companies like Eli Lilly and Merck, and the decision by other companies (such as Pfizer) to back away from the risk - prone field.

Entrepreneur sat down with DeFazio to find out what it takes to make a leap of faith into a new business, staring risk and fear of failure in the face, and finding success.

In this video from our Entrepreneur Live event, Oscar - nominated screenwriter Alan Wenkus sits down with Steve Lehman from Business Rockstars to discuss the importance of taking risks, rising above failures and how to get ahead.

This is the backdrop for The Antidote, in which Vertex struggles to navigate the FDA's demands for patient safety, Wall Street's demands for returns, and its own need to take big bold costly risks that are likely to end in failure.

In a market where any Joe Schmo can pickup a camera and call themselves a photographer, that leaves you, the potential client at risk for failure.

In fact, the link was so strong that for every additional cup of coffee people drank, their risk of suffering heart failure or stroke went down 8 percent, compared to non-coffee drinkers.

«Eating red meat was associated with decreased risk of heart failure and stroke in the Framingham Heart Study,» the heart association press release says.

«We do try to learn from failure, but if you're going to be in the front of the pack, you have to be willing to take on those risks.»

Great companies encourage risk taking and risk taking can often result in failure (see related article, How to Fail Your Way to the Top).

If you are in an industry that is challenging to scale, one where your risk of failure is super high, it may be a good idea to start looking into other opportunities.

Show that you appreciate hard work and risk - taking even in failure.

Courageous companies invest in R&D and offer incentives to employees who take chances, rather than punishing calculated risks that lead to failure.

Employees who are risk - takers will be more willing to assume the risk associated with working in a startup, as they focus on the potential upside of success more than the downside of failure.

If we want to «win championships» in both of those, we have to get others involved, pass more, risk failure, allow teammates to learn from their mistakes by letting them commit them and putting the needs of the group above our own selfish aspirations.

«Key risks include failure of the acquisition, competitive discounting, and wing price trends,» West wrote in a note to clients.

Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.

[24:40] Most entrepreneurs attempt too many businesses in the beginning [24:50] Find your flagship, that you will commit everything to [25:20] Business is also about your own psychology [25:30] Master one thing at a time [26:30] Massive focus and big risks [27:00] The 3 beliefs you must have when starting a business [28:00] Learning how to maximize [28:20] The business you're in and the business you're becoming [28:50] The 80 % of what I do [30:00] The business you are in and the business you are becoming [30:20] Intertwining your personal and professional brands [31:30] The importance of intent [33:20] Tony's take on social media [34:00] Why Tony prefers audio over text [36:40] The value of Facebook Live [37:20] Tony's social media director weighs in on Instagram Stories [38:00] Success without fulfillment is the ultimate failure [39:00] Learning how to master the mind [39:40] What's a magnificent life for you?

Under the 2010 Dodd - Frank Act, which toughened financial regulations in an effort to avoid a repeat of the 2008 crisis, the oversight panel had the power to designate non-bank institutions such as AIG as systemically important financial institutions, meaning that their failure could pose a risk to the entire financial system.

The failure to fully disclose all risks in whitepapers and prospectuses — as required for other securities offerings — remains a point of concern, not only within the country but among the international regulatory community.

At F.Y.I.s, Mayer liked to tell employees that she believed in taking risks and that she was unafraid to admit failure.

Risks associated with investing in Industrials include the possibility of a worsening in the global economy, acquisition integration risk, operational issues, failure to introduce to market new and innovative products, further weakening in the oil market, potential price wars due to any excesses industry capacity, and a sustained rise in the dollar relative to other currencies.

The second is the risk of slow, long - run erosion in real value (or failure to gain real value) in the portfolio due to overweighting low - return holdings.

Personal guarantees will frequently be paired with collateral requirements to lower the bank's risk in lending to you (small business loans are considered risky for banks due to the higher failure rates of small businesses).

Our use of derivatives may increase the risks of investing in the fund by increasing investment exposure (which may be considered leverage) or, in the case of many over-the-counter instruments, because of the potential inability to terminate or sell derivatives positions and failure of the other party to the instrument to meet its obligations.

A well - known problem in financial risk assessment is the failure

First, since monetary policy acts only with a lag failure to raise rates would risk an overheating economy and an acceleration of inflation possibly necessitating a sharp and destabilizing hike in rates later.

Multipliers are frequently used in offsetting to compensate for the risk of failure of the offset measures and the time lag between when negative impacts of the development project are felt and the positive impacts of offsetting come to fruition, often a period of many years.

While the chip industry is attractive, it also carries a reasonably high level of risk; this includes risks associated with concentration of customers, competition, and the possible failure to create a disruptive technology that can be produced in scale.

Important factors that may affect the Company's business and operations and that may cause actual results to differ materially from those in the forward - looking statements include, but are not limited to, increased competition; the Company's ability to maintain, extend and expand its reputation and brand image; the Company's ability to differentiate its products from other brands; the consolidation of retail customers; the Company's ability to predict, identify and interpret changes in consumer preferences and demand; the Company's ability to drive revenue growth in its key product categories, increase its market share or add products; an impairment of the carrying value of goodwill or other indefinite - lived intangible assets; volatility in commodity, energy and other input costs; changes in the Company's management team or other key personnel; the Company's inability to realize the anticipated benefits from the Company's cost savings initiatives; changes in relationships with significant customers and suppliers; execution of the Company's international expansion strategy; changes in laws and regulations; legal claims or other regulatory enforcement actions; product recalls or product liability claims; unanticipated business disruptions; failure to successfully integrate the business and operations of the Company in the expected time frame; the Company's ability to complete or realize the benefits from potential and completed acquisitions, alliances, divestitures or joint ventures; economic and political conditions in the nations in which the Company operates; the volatility of capital markets; increased pension, labor and people - related expenses; volatility in the market value of all or a portion of the derivatives that the Company uses; exchange rate fluctuations; risks associated with information technology and systems, including service interruptions, misappropriation of data or breaches of security; the Company's inability to protect intellectual property rights; impacts of natural events in the locations in which the Company or its customers, suppliers or regulators operate; the Company's indebtedness and ability to pay such indebtedness; tax law changes or interpretations; and other factors.

These risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal, state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher - than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets; risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or other intellectual property; a possible impairment in the carrying value of our goodwill or other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.