Sentences with phrase «fat cell researcher»

Lori Shemek, Ph.D. is a leading fat cell researcher and recognized authority on inflammation and its role in weight loss, preventing disease and optimizing health.

Not exact matches

One preliminary cell study by researchers at Sejong University in South Korea found that piperine may impact fat cells.

«Researchers watch in real time as fat - encased drug nanoparticles invade skin cells.»

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

This suggests that the mixture of these chemicals in house dust is promoting the accumulation of triglycerides and fat cells, the researchers say.

The researchers explain that a high fat diet boosts cell metabolism, including the release of inflammatory chemicals, as well as influencing the gut microbiome and associated immunity.

«Fat cells can adopt a range of metabolic phenotypes, depending on physiological conditions and location in the body,» said James G. Granneman, Ph.D., a researcher involved in the work from the Center for Integrative Metabolic and Endocrine Research at the Wayne State University School of Medicine in Detroit, MI.

The researchers found that they could trigger the same effects in healthy muscle cells by exposing them to the fat palmitate.

Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function.

It appears to work by adjusting the body's metabolism, allowing muscles to favor burning fat over sugar, researchers report in the May 2 Cell Metabolism.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

After reading Morrison's work, Siddaraju Boregowda, a stem cell researcher at the Scripps Research Institute in Jupiter, Florida, was reminded of genetically altered mice that don't gain body fat or develop diabetes, even when fed high - fat diets.

He and his boss, stem cell researcher Donald Phinney, wondered whether those mice were also protected from the fattening of the bone marrow that accompanies a high - fat diet.

The plant compounds used by the UGA researchers — resveratrol, found in grapes; genistein, found in soybeans; and quercetin, found in apple peels and onions — have all been shown in previous studies to be fat - busters, causing fat cells to burst and release their contents.

Components of indoor dust may signal human fat cells to grow and may alter metabolism, potentially contributing to weight problems, researchers report July 14 in Environmental Science & Technology.

The researchers obtained stem cells from the discarded fat of liposuction patients who underwent elective surgery.

As a patient's BMI increases, fat cells communicate with multiple myeloma cells, researchers found.

Now, Salk researchers have discovered how the molecule ERRγ gives this «healthier» brown fat its energy - expending identity, making those cells ready to warm you up when you step into the cold, and potentially offering a new therapeutic target for diseases related to obesity.

Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused fat cells that would normally become healthier beige to turn into white fat cells instead.

Researchers previously thought that fat cells were mostly responsible for making lipocalin 2, or LCN2.

Now researchers from the University of Southern Denmark have uncovered the mechanism by which white fat cells from humans get reprogrammed to become browner.

The UI researchers used immortalized fat cells to show that bacterial toxins stimulate fat cells to release molecules called cytokines, which promote inflammation.

To determine how fat might alter glucose uptake, the researchers measured the production of blood - borne molecules that fat cells secrete.

By 1999 researchers from Japan's National Cardiovascular Center Research Institute in Osaka had announced the discovery of ghrelin, a kind of antileptin that is released primarily by the gut rather than by fat cells.

Researchers have turned their attention to these cells because some of the sugar and fat they burn is stored in the body and might otherwise lead to increases in white fat, the form that increases in obesity.

The researchers used the new lab - on - a-chip to study how adult stem cells in adipose tissue develop into mature fat cells, conducting their investigations outside the body.

Harvard School of Public Health (HSPH) researchers have discovered that a particular type of protein (hormone) found in fat cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver.

The researchers were surprised to find that knockdown of one specific mitochondrial chaperone, mtHSP70, elicited a unique stress response mediated by fat accumulation, resulting in improved protein folding in the interior or cytosol of the cell.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

This is more than a mere change of color, as the researchers also found that these bile acids increase the number of mitochondria in the new fat cells.

In mice that gorged and then fasted, the researchers saw elevations in inflammation, higher activation of genes that promote storage of fatty molecules and plumper fat cells — especially in the abdominal area — compared to the mice that nibbled all day.

The researchers now want to find out exactly how Tregs interact with fat tissue and whether the immune cells accumulate in other organs during normal aging.

Researchers at the University of Michigan have identified how a promising drug in clinical trials for the treatment of obesity and related metabolic disorders improves the metabolism of sugar by generating a new signal between fat cells and the liver.

Given the similar results, the researchers believe that fat cells plus SVF are preferable to stem cell injection.

By collecting samples from three different groups of patients, the researchers were able to compare the health of the precursor fat cells of the three groups.

The defect in the creation of the fat cells means that the women's bodies are more likely to have problems using blood sugar, the researchers found.

RIPK1, the researchers found, inflicts damage by directly attacking the body's myelin production plants — nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from damage.

The researchers discovered that one strain had a genetic defect in fat cells that secrete a hormone called leptin.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

While doctors, nutritionists and researchers have known for a long time that saturated fats contribute to some of the leading causes of death in the United States, they haven't been able to determine how or why excess saturated fats, such as those released from lard, are toxic to cells and cause a wide variety of lipid - related diseases, while unsaturated fats, such as those from fish and olive oil, can be protective.

Researchers scanned the brains of two voracious teenagers whose fat cells were unable to secrete leptin normally, but after being given the hormone for a week became pickier eaters.

In others, the researchers altered a gene that regulates phospholipids, the primary type of fat in cell membranes, which spurred the cells into producing more cholesterol on their own.

In the current study, published in Cell Reports, the researchers investigated the relationship between p75 NTR and a diet high in fat — often the cause of these problems.

As the researchers have shown in various studies on mice, the widespread active ingredient sildenafil or a medication against pulmonary hypertension, for instance, can be used to reduce the number of white fat cells to the benefit of the brown fat cells and thus accelerate fat burning like a turbocharger.

In the 1990s, researchers tried using a virus or fat particles to insert the correct CFTR gene into patients» lung cells.

The researchers posit the explanation that kynurenic acid activated the cell receptor GPR35, which is found in both fat cells and immune cells.

If the researchers» dream comes true, brown fat cells could be boosted with yet - to - be-developed active substances such that rolls of fat could simply be melted off.

The researchers observed that there is a particularly high number of receptors in brown fat cells which bind to the Gq protein.

In a recent study, the university researchers show why the inflammatory responses that often occur in overweight people block this kind of fat cell conversion.

Their ability to remain diabetes - free, researchers have now discovered, can be chalked up to the shutting down of a protein found in fat cells.