While the treatment did have some
favorable effects, in the main measure of outcome — measured with a
cognitive test called the Alzheimer's Disease Assessment Scale -
cognitive subscale — the researchers did not observe any statistically significant benefit compared with placebo.
Five programs demonstrated
favorable effects on ≥ 1 measure of
cognitive development: (1) Child FIRST on 2 measures of language development53, (2) EHS on 2 measures of a mental development index and approaches to learning54, 55; (3) HFA on mental and
cognitive development28, 30; (4) HIPPY showed 1
favorable effect on vocabulary56; and (5) NFP had a
favorable effect on language.12 Three programs (Early Start, PALS for Infants, and PAT) showed no
favorable effects on measures of
cognitive development, 25,26,37 — 40,57 — 60 and no results were reported for EIP, Family Check - Up, Healthy Steps, and Oklahoma's CBFRS.