For example, if it was raining at the time a child was in a car accident, a child might connect rain with
the fearful memories of the car accident.
Specifically, the findings explain how a particular gene — called fkbp5 — is involved in a phenomenon known as «fear extinction,» through which animals and humans disassociate with
fearful memories of a traumatic experience, such as war, assault or a natural disaster.
They herded each mouse into a special cage and delivered a mild electric shock to its foot, leading the mouse to form
a fearful memory of the cage.
Not exact matches
I just have a lot
of FEARFUL memories.
As the animals learned, the researchers recorded electrical signals from individual neurons in the amygdala, a brain structure that forms
memories of fearful experiences.
«It's very interesting work but not practical for clinical treatment
of patients,» says Denis Paré, a neuroscientist at Rutgers University in New Jersey who is also studying pharmacological approaches to manipulating
fearful memories.
Some scientists might explore how and why the neural circuits that detect threats and store
fearful memories sometimes behave in unusual ways after traumatic events — the kinds
of changes that are partially responsible for post-traumatic stress disorder.
A mouse's
memory of a single
fearful event is one thing; the complex associations
of human
memory, powered by a dense network
of neuronal connections, is quite another.
«If the effects
of alcohol on
memories to
fearful responses are similar in humans to what we observe in mice, then it seems that our work helps us better understand how traumatic
memories form and how to target better therapies for people in therapy for PTSD.
Results
of their study demonstrate, they say, that alcohol strengthens emotional
memories associated with
fearful experiences and prevents mice from pushing aside their fears.
«These drugs, together with alcohol, may affect the ability to let go
of fearful memories in different ways.»
The next day, when both sounds were played, the rats who had been given the drug were
fearful of the siren but not
of the beep, suggesting that the beep - plus - shock
memory was blocked.
«Extinction
of fearful memories and extinction
of drug - seeking
memories relies on the same substrate in the brain.
The new work reveals that at least one form
of long - term
memory — that
of fearful experiences — seems to become fragile when reactivated.
Scientists must still discover whether
memories other than
fearful ones undergo a similar kind
of reprocessing when they are retrieved.
Now, though, at the very moment in which a rat remembered the shock, the scientists injected an antibiotic that inhibits the synthesis
of new proteins into its amygdala — a part
of the brain long known to store lasting
memories of fearful experiences.
They found that dexamethasone, a widely prescribed steroid for inflammatory conditions, affects the expression
of fkbp5 in the brain, preventing the formation
of the
fearful memories that are the hallmark
of PTSD.
«If dexamethasone works well in humans, we could potentially use it to prevent
fearful memories in soldiers on the battlefield, patients in emergency rooms, or anywhere else where healthcare providers provide treatment within hours
of traumatic events.»
«Turning down the brain to erase
fearful memories: Weakening communication between two parts
of the brain in mice reduced their fear levels.»
«Much
of extinction training — the process
of learning that a
fearful cue is no longer
fearful — in adult rodents closely parallels aspects
of exposure - based psychotherapy for humans, where an exposure to a stimulus that was associated with trauma shares many aspects
of the initial traumatic
memories.»
Pointing to the change in amygdala activity, which is central to the brain's system
of storing and recalling
fearful memories (see How Fear Works to learn about this process), the researchers say the
memory was not simply disconnected from fear, but that it was actually erased in its entirety.
Now, in a study published online by the journal Nature Neuroscience, researchers from Israel's Weizmann Institute
of Science say that by weakening the communication between neurons in two parts
of a mouse's brain, they've been able to erase a
fearful memory.
This region
of the brain is hardly blah, though, as Tonegawa and his team determined that the two groups
of neurons are genetically programmed to encode either
fearful or happy
memories.
Drugs that block these receptors have been shown to block the formation
of fearful memories and to reduce the anxiety associated with alcohol withdrawal in rodents.»
It takes a lot
of courage to admit; I was
fearful I wouldn't be able to savor the first
memories with my newborn because «bouncing back» would be at the forefront
of my thoughts.
This film thus does ask this question, and it does so with the intelligence that has characterized the filmmaker over the years: What does vengeance mean when the
memory of the avenger is slowly vanishing, the self slowly losing itself, fading from its
fearful recipient, a soulless search to vindicate wrongs he no longer remembers?
When your dog or cat experiences a
fearful situation (stimulus), anxiety is increased and a deep seated, lasting
memory of the experience is buried in your pet's brain.
The
memories of a traumatic collision can haunt victims leaving them
fearful or even unable to drive.
A significant emphasis is on the biology
of fearful memory, which we dissect using Pavlovian conditioning paradigms.
In more mature persons, however,
memories of fearful events are put in perspective, and people generally do not feel the same fear they felt as a child when confronting a similar situation as an adult.