«A prominent and well - characterized
feature of AD is progressive, region - specific declines in the cerebral metabolic rate of glucose (CMRglc)-LSB-...] Carriers of a common Alzheimer's susceptibility gene [APOE Ɛ4] have functional brain abnormalities in young adulthood, several decades before possible onset of dementia.
Aβ results from the normal cleavage of amyloid precursor protein (APP), but its accumulation and aggregation into plaques represents the quintessential
feature of AD.27 Aβ is found in orders of magnitude greater in AD brains than in healthy brains.28 This fact is noteworthy because lower concentrations of Aβ tend to stay soluble; higher concentrations form plaques more readily.29
A noteworthy
feature of AD is the intriguing combination of hyperinsulinism (too much) in the periphery and hypoinsulinism (not enough) in the CNS.
The next major
feature of AD is the loss of connections between neurons.
«Atrophy of the hippocampus, a region of the brain crucial for memory, is a common
feature of AD, although it may also be detected in asymptomatic individuals as well as healthy adult carriers of the ApoE ɛ4 allele,» explained Andy Simmons, PhD, of the Department of Neuroimaging of the Institute of Psychiatry of King's College London.
By using
the feature of ad scheduling, you can set which days of the week and time you want to run your ads on.
The anti-abortion targeting effort relies on
a feature of ad networks known as geofencing.
This study used the well characterized APPswe / PS1ΔE9 mouse model that exhibits a subset of behavioral and pathological
features of AD, including age - dependent accumulation of beta - amyloid (Aβ) as well as learning and memory deficits [10].
Not exact matches
Features like Live Video, Instant Articles and Canvas
ads are shaking up digital marketing and might be a cause
of concern for advertisers.
The fast food chain brought the mobile icons to life in a French
ad that
features a city full
of people with animated 3D emojis for heads.
The new
feature allows them to get a broader picture
of what potential consumers are interested in, and to target
ads towards them based on data from what the company calls its Topic Engine.
While some artists will continue to have reservations about having their work
featured in
ads, Gardner and Hayman say there is still a greater likelihood
of people finding a new band or their favourite new song in a television show these days than there was a decade ago.
Flipboard's head
of ad product, Dave Huynh, explains how the new
feature works: If an advertiser says they are looking to appeal to readers who are interested in big data, for example, Flipboard can look into its interest graph and tell them that readers who like that topic are also interested in other topics such as Amazon and the cloud.
The
ad features footage
of Williams throughout her career as she voices over an account
of all the ways she's been criticized for not being womanly enough before saying «[b] ut I'm proving time and time again that there's no wrong way to be a woman.»
While a dozen major merchants are currently piloting the
feature, which enables users to purchase items directly from
ads displayed in Google search results, Google told Entrepreneur that it ultimately plans to roll out the
feature to «retailers
of all sizes.»
Many marketers and small - business owners believe their customers will be enticed to come shopping if they are shown a list
of features in an
ad but time and time again, the
ads that speak to the solution outperform
feature ads.
Instead, he offered to sign on as the conference's «gold sponsor,» albeit on his own terms: in exchange for the $ 30,000 sponsorship fee — a booth normally runs between $ 850 and $ 1,870 — he asked for a booth in the middle
of the hall, the exclusive right to put Starvox's
ads on the hotel's room key cards, and permission to run a continuous video loop
featuring the company's shows on the screens in the elevators.
The two - minute «documentary,» created by
ad agency 72andSunny (which is owned by MDC)
features controversial military vet Ollie North and author P.W. Singer talking about the cornucopia
of ways advanced technology could be used to hasten our grisly demise.
She added that «the use
of the targeted age - range selection on the Facebook
ad was frankly a mistake on our part given our lack
of experience using that platform for job postings and not a
feature we will use again.»
There are two places you must look to deactivate these pesky display
ad featured placements; make sure you check both
of them to prevent any further mobile
ad clicks from coming through to your display campaigns.
Improvely isn't just a prevention tool as the system also supplies conversion tracking
features to uncover the source
of each signup or sale to help you understand which
ads are working, and which are floundering.
This might be surprising coming from a company known for Super Bowl advertisements
featuring scantily clad women, but GoDaddy hasn't aired those kinds
of ads in four years.
See, the gap - toothed goal scorer got off to a rocky start in the
ad game — perhaps following Mario Lemieux's lead with a bizarre local car dealer commercial — but quickly turned things around last year with a series
of quirky spots for Reebok CCM that
featured his decapitated head's crazy - person / evil genius laugh, and a turn for ESPN's SportsCenter that pegged him as a Russian spy.
Picture this: An
ad featuring three non-native people dressed up like native people, covered in white powder for some reason, defending the purity
of bottled water with spears.
Girls still e-mail pictures to Charney in hopes
of being
featured in
ad campaigns, which he occasionally photographs.
Picture this: An
ad featuring three non-native people dressed up like native people defending the purity
of bottled water with spears.
To mark a quarter century
of Just Do It, Nike this week dropped a new
ad featuring star athletes like LeBron James, Serena Williams, Gerard Pique and Andre Ward, all narrated by Bradley Cooper, that urges you to step up your game.
The
ad, which
featured Jenner joining a vague protest and giving a police officer a can
of soda to diffuse the situation, was accused
of trivializing social movements like Black Lives Matter.
John St.'s first creative work for Shoppers was a print
ad in Women
of Influence earlier this month — it
featured a coffee cup marked with a woman's lipstick and declared, «Some marks you leave are more permanent than others.»
But perhaps the biggest signal
of Amazon's high hopes for Echo is the fact that it will be prominently
featured in the online store's first - ever Super Bowl
ad, which was announced today.
The virtual world is full
of features and
ads that may trick you to adopt beliefs, buy products or just stare at the screen longer.
Unilever, the parent company
of dozens
of household brands such as Dove, stopped producing
ads featuring gender stereotypes in 2016 upon determining that a mere 2 percent
of all
ads feature intelligent women, 3 percent show women in positions
of power and 1 percent portray women with a sense
of humor, Fortune reports.
Airbnb's
ad featuring a diverse group
of people touting a message
of acceptance will be seen by many as a criticism
of Trump's immigration policies.
campaign and replace it with Milk Life, a new set
of ads that tout milk's protein count,
featuring regular people doing active things.
One
of the more powerful
features of Facebook
ads we started to leverage this year is what's known as website conversion optimized bidding.
Kellogg's chose to spend more money promoting a version
of the
ad featuring an alien instead, because it held up better upon second viewing.
Opera claims the
ad - blocking
feature can speed up the loading
of pages by up to 90 %, providing a 40 % faster browsing experience than that achieved with
ad - blocking plugins.
Ads featuring SpongeBob aren't going to cut it in the eyes
of the modern consumer, who has unfettered access to nutrition data online and a consciousness about the production and retailing
of the items they buy.
Kolondra also said Opera is not talking with its mobile - operator partners about instituting the
feature in its (far more widely used) mobile versions — many operators are controversially experimenting with blocking
ads at the network level rather than in the browser, partly as a way
of getting publishers and
ad networks to give them a slice
of their revenue.
Puzder's treatment
of women has also been questioned, related in part to widely criticized
ads that
feature scantily - clad female celebrities eating hamburgers.
IKEA took aim at Apple's habit
of grandiose launch announcements and reverent product spots with this
ad featuring the Swedish furniture firm's new product catalogue.
Apple's chief mobile rival released a whole series
of ads poking fun at the «exciting» «new»
features of the devices, pointing out that many are already staples
of Samsung's Galaxy line
of smartphones and wearables:
(Roughly speaking, a print
feature will cost anywhere from a third to half the price
of a color
ad in the same publication.
And with Facebook and Snapchat locked in a fierce battle for users and
ad dollars, the familiar look
of Instagram's latest
feature did not go unnoticed by the creators
of the original disappearing - photos app.
Shot in black and white, the
ads feature the ladies — each
of whom is now in her 40s — bedecked in structured gowns and, in some shots, clutching one another in seeming sisterhood.
SAN FRANCISCO — When Steve Jobs adopted «think different» as Apple's mantra in the late 1990s, the company's
ads featured Albert Einstein, Bob Dylan, Amelia Earhart and a constellation
of other starry - eyed oddballs who reshaped society.
The
feature has the potential to drum up quite a bit
of money for a wide swath
of YouTube creators, the vast majority
of whom make almost no money from the platform's pre-roll
ads.
After
featuring actor Anthony Hopkins last year, the tax prep software company is back with a teaser for a three - part series
of ads showing Humpty Dumpty falling off a wall while doing his taxes.
Goldman Sach's three video
ads feature its 10,000 Women initiative, and will show up in Snapchat's Live Story for International Women's Day and in the Discover channels
of four publishers — BuzzFeed, Vice, National Geographic, and Refinery29.
And the company tells Fortune that in coming months Twitter will roll out new
features and
ad products, including a set
of services aimed at helping small businesses market themselves on Twitter.