Accumulation
of misfolded protein aggregates is not only present in T2D but also is the main
feature of a group
of diseases known as protein misfolding disorders (PMDs), including various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and prion disorders, as well as several systemic amyloidosis disease (Luheshi et al., 2008; Soto and Estrada, 2008).