Stomach pain (more fancily called a liver - spleen disorder): the distinguishing
feature of this disorder that begins suddenly with sharp cries.
The name is apt, because the most conspicuous
feature of the disorder is a withdrawal from social interaction.
«The physical
features of the disorder are not well known, making it difficult for pediatricians to diagnose,» said Dr. Close, who conducted this study while a doctoral student at Columbia University School of Nursing.
To date, researchers have created 676 mouse models that supposedly capture
some features of the disorder.
Even the revised fourth edition of the American Psychiatric Association's diagnostic manual, published in 2000, specifies the core
features of the disorder as the «presence of two or more distinct identities or personality states.»
In fact, a lack of eye contact is one of the diagnostic
features of the disorder.
Its presence in all erythropoietin - independent erythroid colonies demonstrates a link with growth factor hypersensitivity, a key biological
feature of these disorders.
Taken together, these findings suggest that brain stimulation may reduce symptoms of anorexia by improving cognitive control over compulsive
features of the disorder,» McClelland said.
Weight loss is particularly difficult for women with PCOS as one of
the features of this disorder is that it makes you gain weight faster and easier than other people do (Teede et al. 2010).
It is not unusual for individuals with oppositional defiant disorder to show the behavioral
features of the disorder without problems of negative mood.
Aggressive behaviours towards other persons or animals or properties, as well as deceitfulness, theft or other severe violations of rules are the core
features of this disorder [2].
Not exact matches
Doctors can snap pictures
of their patients and upload them to FDNA's mobile app, which then spits out a list
of disorders they might have by analyzing telltale facial
features associated with those conditions (the tech is not a diagnostic tool, but rather a way to narrow down the list
of possible genetic suspects).
Another proposed revision to the new DSM qualifies the definition
of personality
disorders: this diagnosis «excludes culturally normative personality
features.»
One
of the hallmark
features of autism spectrum
disorders is social impairments.
Babies with Jacobsen's experience a multitude
of symptoms, including delayed development, cognitive impairment, behavioral issues, distinctive facial
features, feeding difficulties, and almost all have Paris - Trousseau syndrome, a bleeding
disorder.
In the past, the API Live teleseminars have
featured Dr. Kathleen Kendall - Tackett discussing parental depression, Dr. Bob Sears chatting about autism spectrum
disorders, Mothering magazine editor Peggy O'Mara discussing how we can get real with ourselves and our children, Ina May Gaskin speaking on the topic
of the gift
of loving your best birth, and much more.
So autism spectrum
disorders are diagnosed based on a set
of features.
In our input to the committee we wrote: We continue to support the recommended addition
of a specifier, as it is stated on the DSM 5 website, «With Postpartum Onset,» that can be applied to a current or most recent Major Depressive Episode, Manic, or Mixed
Features in Major Depressive
Disorder, Bipolar I
Disorder, or Bipolar II
Disorder, or to Brief Psychotic
Disorder, and that the onset
of the episode be extended to within 6 months postpartum.
Most
of the time «elf ears» are harmless and nothing more than a cute
feature which is why it has a place on this list, but in some cases it can be a symptom
of an ear
disorder that can need further medical attention.
This video from the Kennedy Krieger Institute, in Baltimore,
features three children who show early signs
of autism spectrum
disorder playing with toys and interacting and communicating with others.
Given these
features of kettling, one might argue that his opinion subverts itself: the predictable effects
of kettling, in terms
of increasing
disorder and risk
of injury to (innocent) parties, are such that it can never - or hardly ever - be a «proportionate» and / or «good faith» response to a problem
of disorder in a protesting crowd.
But studying this tissue can not reveal the
features of such
disorders that are more related to behaviour, she says.
Now, CNIO researchers have discovered a new
feature of this inflammatory
disorder.
Muotri's work is a nice demonstration
of the power
of mini-brains to help understand the early, cellular
features of neurological
disorders, says Madeline Lancaster at the MRC Laboratory
of Molecular Biology in Cambridge, UK, who developed the organoid - growing method Muotri used.
Beyond PSP, other brain diseases are also marked by abnormal tau clumps — among them a rare movement
disorder called corticobasal degeneration, an inherited form
of frontotemporal dementia with Parkinson's - like
features, and Alzheimer's disease.
One such study
featured data finding a correlation between children with Attention Deficit Hyperactivity
Disorder (ADHD) and high levels
of lead in the blood.
Scientists know that accumulation
of somatic DNA mutations is a
feature of aging, though little data exists on the role
of such mutations in age - associated
disorders beyond cancer.
Early signs
of BD can fall into a relatively characteristic «homotypic» pattern, consisting mainly
of symptoms or other
features associated with mood
disorders; or a «heterotypic» pattern
of other symptoms including anxiety and disruptive behavior.
Researchers would then have to pore through four or five databases for each one, trying to discern which genes (or the proteins they encode) have
features most likely to affect the biology
of the
disorder — a painstaking task.
Clinical
features of major depressive
disorder (MDD) may help identify specific subgroups
of depressed patients based on associations with genetic risk for major psychiatric
disorders, reports a study in Biological Psychiatry.
The authors
of On the Beauty
of Physics
feature «The Last Supper» as a case study
of entropy — a measure
of the tendency toward
disorder in a thermodynamic system.
As Beau vividly illustrated, the
disorder's most conspicuous
feature is cataplexy, which can range from a mere sagging
of the jaw and buckling
of the knees to full, severe, and instantaneous rag - doll limpness that can last for minutes.
Mutations in a gene called progranulin (GRN) are commonly associated with frontotemporal dementia, but GRN mutations in mice do not mimic all the
features of the human
disorder, which has limited progress in the development
of effective treatments.
In September, Hagerman and colleagues reported that arbaclofen, a drug that stimulates a type
of GABA receptor, reduced social avoidance in people with fragile X syndrome, a genetic
disorder that shares many
features with autism.
The current edition
of the DSM, the DSM - IV, is something like a field guide to mental
disorders: the book pairs each illness with a checklist
of symptoms, just as a naturalist's guide describes the distinctive physical
features of different birds.
The letter further contends that recent chimp studies for the first time have identified «unique
features of the human brain and have documented the unusual vulnerability
of humans to a variety
of disorders, including Alzheimer's disease, infectious diseases, cancer, and heart disease.»
Stephen W. Scherer, Ph.D.,
of the Hospital for Sick Children, Toronto, and colleagues performed chromosomal microarray analysis (CMA) and whole - exome sequencing (WES) in a group
of 258 unrelated children with ASD to determine the molecular diagnostic yield (the percentage
of subjects with a genetic alteration [mutation] that may contribute to the
features of autism spectrum
disorder)
of these tests.
The invocation
of cell death in this
disorder would explain the clinical
feature, the small heads caused by loss
of nerve cells in the brain, the team found.
«Mouse behavior isn't the same as human behavior, so we need to be cautious, but we were surprised and heartened by the fact that the mutant mice responded to lithium treatment — a gold standard for treating human bipolar
disorder and alleviating
features of mania and depression,» says Christopher Ross, M.D., Ph.D., professor
of psychiatry and behavioral sciences at the Johns Hopkins University School
of Medicine.
Dr. Coban explains, «Although chronic inflammatory conditions are known to facilitate bone
disorders, our study - for the first time - shows that malaria can do the same thing, with hallmark «signatures» left in the bone tissue, a very unique
feature of malaria infection.
In 2002 psychologist Paul Nestor
of the University
of Massachusetts Boston found that individuals with marked
features of NPD are at risk for violence and for antisocial personality
disorder, a condition that is tied to crime and other irresponsible acts.
In the course
of screening over 180 mutant mouse strains with a systematic battery
of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout
of the alpha - isoform
of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain
features consistent with bipolar
disorder.
This «chromosomal
disorder» is a key
feature of the gibbon genome and has probably occurred after their secession from the ancestral line
of the apes and humans.
The results are also important as they suggest that the same sets
of genetic risks contribute to different aspects
of child development which are characteristic
features of neurodevelopmental
disorders such as ADHD and autism spectrum
disorder.»
Accumulation
of misfolded protein aggregates is not only present in T2D but also is the main
feature of a group
of diseases known as protein misfolding
disorders (PMDs), including various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and prion
disorders, as well as several systemic amyloidosis disease (Luheshi et al., 2008; Soto and Estrada, 2008).
This year's ASENT meeting
featured a symposium on spinal muscular atrophy (SMA), an inherited motor neuron disease that is the second most common autosomal recessive
disorder of children and the most common genetic cause
of death in infancy, as a case study in neurology orphan drug development.
Lastly, increased systemic inflammation seen during ageing is also apparent in chronic infections such HIV or cytomegalovirus, 10,15 obesity7 and individuals enduring chronic psychological stress.16 Similarly, the main
features of immunosenescence are apparent in many
of these conditions, including decreased antibody responses, increased infections, malignancies and also incidences
of inflammatory associated
disorders such as cardiovascular disease.7, 10,15,16 Inflammation and premature immunosenescence are, therefore, prevalent
features of many common conditions
of modern life, such as obesity and stress, and could have negative health consequences for large proportions
of society well before old age is reached.
While patients with neurodevelopmental
disorders like intellectual disability and autism spectrum
disorder have clinical
features which overlap, there is an enormous diversity
of underlying genetic causes.
Understanding these hereditary and interrelated
disorders will require better in vitro liver models that capture important physiological
features of disease progression.
Patrick Bellgowan, Ph.D., a program director at the National Institute
of Neurological
Disorders and Stroke at NIH, says the study is a clear demonstration
of how the open science approach to data can help generate new hypotheses about brain
disorders: «Through data sharing and collaboration, ENIGMA is working to uncover important common and distinguishing neurobiological and genetic
features of psychiatric and neurological
disorders.»