Sentences with phrase «features of the human disease»

With that in mind, the Penn Vet team chose to examine two of their well - established canine models of RP, which recapitulate many features of the human diseases, each involving mutations in different genes.

Prof. Jean - Christophe Marine (VIB - KU Leuven) and others developed mouse models recapitulating some of the key histopathological features of the human disease.

for example, no HD mouse model shows signs of «chorea», the dance - like movements that are a common feature of the human disease.

Because the fly modeled the key features of the human disease, researchers can now screen proteins and molecules quickly to see which might have therapeutic effects.

Not exact matches

Former EPA Region 2 Administrator Judith Enck, who was featured in the Politico article and is also a regular voice on WAMC, called the actions by EPA and the Department of Defense «scientific censorship» of the report being compiled by the Department of Health and Human Services» Agency for Toxic Substances and Disease Registry.

But within days skeptics emerged, countering that the tiny remains instead belonged to a small - bodied population of modern humans and that LB1 — with her tiny brain and other odd features — was a diseased member of the group.

The letter further contends that recent chimp studies for the first time have identified «unique features of the human brain and have documented the unusual vulnerability of humans to a variety of disorders, including Alzheimer's disease, infectious diseases, cancer, and heart disease.»

Disease in IL10 - / - mice closely resembles the physiological, histological and biochemical features of chronic colitis in humans.

A task force meeting on 6 and 7 May in Washington, D.C., will feature «invited speakers from the National Academies, the American Chemical Society, the U.S. Chemical Safety and Hazard Board, the Centers for Disease Control and Prevention, Oak Ridge National Lab, Association for the Accreditation of Human Research Protection Programs, Campus Safety, Health, and Environmental Management Association, and American Biological Safety Association,» according to the announcement.

«Previous studies in mice have indicated that bacteria that are able to encroach upon the epithelium might be able to promote inflammation that drives metabolic diseases, and now we've shown that this is also a feature of metabolic disease in humans, specifically type 2 diabetics who are exhibiting microbiota encroachment.»

It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.

«This is an exciting new tool to answer important questions about proteins,» Cochran said, likening µSCALE to the way that high - throughput tools for gene analysis have allowed researchers to unlock key features of biology underlying human disease.

Mackenzie is one of a small band of scientists who are trying to work out why Australia is suffering from a rash of «zoonoses», diseases that jump from animals to humans, and why, in almost every case, a bat features somewhere in the story.

The authors unveil a novel mouse model of chromosome Xq22.1 deletion syndrome, a human disease characterized by developmental delay, intellectual disability, epilepsy, dysmorphic features, and an X-linked pattern of inheritance.

This mouse model for AIDS dementia mimics several features of the disease process found in humans.

Thus, to the best of our knowledge, the amelioration of progeroid features observed here is the first in vivo demonstration in compound heterozygous animals of interallelic complementation relevant to a human disease.

For example, beluga whales live rough 50 some years, they are short - lived whales, some of them get type II diseases and as such, show diabetic human - like features of accelerated collagen crosslinking by AGEs production during glycation / glycoxidation to their hyperglycemia.

«Although FTD and NCL patients differ markedly in age and clinical manifestations, we wanted to know if humans who carry FTD - related genetic mutations in progranulin share features with NCL patients,» said Li Gan, PhD, associate director of the Gladstone Institute of Neurological Disease and professor of neurology at UCSF.

«We haven't had human cellular models that faithfully reproduce this feature of the disease,» said Gottesfeld.

Her laboratory focuses on (1) the use of next generation sequencing to define the microbiome and host immunologic features in patients with human diseases and (2) developing custom computational tools for the identification of novel human commensals and pathogens in these inpatient populations, and (3) using statistical and functional biological methods to understand the complex interplay between the human microbiome and host biology.

Taken together, these results demonstrated that disease - specific human iPS cell — derived hepatocytes are capable of modeling key pathological feature of A1ATD in vitro and may also prove useful for future drug screening assays.

Pandemics — global outbreaks of disease across countries and continents — have been a feature of human history for centuries: as inexplicable and frightening as the contagion in Emily Shultz's novel The Blondes, where women with blonde hair are turned into crazed maniacs.

Pathologic accumulation of lipofuscin in the RPE is also a feature of several human diseases, including fundus flavimaculatus (Stargardt's disease)[43], but at this point it remains unclear which human condition is most closely modeled by Swedish vallhund PRA.

See U.S. Department of Health and Human Services, Center for Disease Control and Prevention, National Center for Health Statistics, Health, United States, 2015: With Special Feature on Racial and Ethnic Health Disparities, Table 50, p 192.