Not exact matches
When the research team took
fecal samples from responding patients and
transplanted them
into germ - free mice — «essentially reconstituting the mice's gut microbiomes with a responding patient's microbiome,» she says — they discovered that the mice had better immunity.
In additional tests, the scientists found they could restore the norovirus infections by
transplanting fecal material from untreated mice
into mice that earlier had been treated with the antibiotics.
The procedure, which has a 90 percent success rate,
transplants the
fecal microbial ecosystem from a healthy person
into a sick one, often using a colonoscope for inserting the material, to restore a healthy equilibrium.
A team led by University of Minnesota immunologist and gastroenterologist Alexander Khoruts has recently demonstrated spectacular success with
fecal transplants, which introduce healthy stool microbes
into a diseased bowel.
In the first study, scientists
transplanted fecal material from exercised and sedentary mice
into the colons of sedentary germ - free mice, which had been raised in a sterile facility and had no microbiota of their own.
Ridaura et al. (1241214; see the Perspective by Walker and Parkhill) obtained uncultured
fecal microbiota from twin pairs discordant for body mass and
transplanted them
into adult germ - free mice.
We
transplanted fecal microbiota from adult female twin pairs discordant for obesity
into germ - free mice fed low - fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet.
The procedure, called a
fecal transplant, typically involves collecting and processing stool from a healthy relative and feeding it through a nasal tube
into the patient's small intestine.
Using
fecal transplants, researchers transferred microbiota from IBS patients with or without anxiety
into germ - free mice.
This will include a project funded by Stand Up to Cancer that involves
fecal transplants from patients who responded to therapy and from non-responders
into germ - free mice providing favorable and unfavorable microbiomes to study in detail.
The study provides insight
into the structural and potential metabolic changes that occur following
fecal transplant, says senior author Vincent B. Young, MD, PhD, an associate professor in the Department of Internal Medicine / Infectious Diseases and the Department of Microbiology & Immunology at the University of Michigan in Ann Arbor.
For example, 2013 saw studies showing that
transplanting human
fecal microbiota
into mice could induce obesity and its associated metabolic phenotypes, and human data from a controlled study suggesting the procedure could treat recurrent C. difficileinfection.
Fecal transplant, otherwise known as bacteriotherapy, is the method of introducing microbes from healthy donors
into the gastrointestinal (GI) tract of people suffering from severe stomach problems, such as recurrent C. difficile colitis.
Physicians have discovered that
transplanting screened and processed
fecal material from a healthy donor
into the colon of a sick patient can cure C. difficile infection in 90 % of cases.
Another is looking
into Type 2 diabetes, and one is even using lean donors to test
fecal transplants on patients with metabolic syndrome.
Make sure your PCP knows that you have undergone a
fecal transplant to treat C. difficile so that he or she may factor this history
into decisions about your care.
Scientists are excited by recent success with
fecal microbiota
transplants (FMT), transfer of healthy
fecal matter
into ailing patients, notably those with clostridium difficile (C. diff), a bacterial infection acquired after antibiotics, often in hospitals, that kills more than 15,000 people a year.
I am also booked
into the CDD in Sydney to undergo
Fecal transplant therapy.
In the first study, researchers
transplanted fecal material from both exercised and sedentary mice
into mice with sterile guts.
We are in an age when
transplanting fecal matter (poop) from one person
into another is a «thing.»