Rats
fed on alternate days showed preserved kidney function as demonstrated by preserved glomerular filtration rate and renal plasma flow, compared to rats fed ad libitum.
At four weeks, rats in the high - fat group were then separated into two groups: one half continued to receive daily access, whilst the other half were
fed on alternate days (i.e. underwent IER) for a further six weeks.
Not exact matches
If your first
feeding of the
day is
on the right breast,
alternate to the left breast for the second one, and so
on.
Compared to ad libitum
fed controls, rodents maintained
on IER (100 % ER /
alternate days) for periods of 12 to 24 weeks typically exhibit lower post-treatment levels of fasting glucose 14, 16, 17, 29 and insulin.16, 17, 29 Using this particular IER protocol, Jiang et al28 have also demonstrated an increase in oral glucose tolerance and tissue insulin sensitivity (measured using a hyperinsulinemic - euglycemic clamp) after four weeks in healthy rats.
Studies in rodents have additionally described post-treatment elevations in the rate of fatty acid oxidation within both the liver and skeletal muscle of mice maintained
on IER (100 % ER /
alternate days).13 In a comparison of CER (40 % ER /
day) and IER (100 % ER /
alternate days), the authors of this 20 - week study noted a doubling in the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER -
fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insulin.
In 1945, experiments showed rats who
fed only
on alternate days received the same overall benefits in terms of increased lifespan as those eating less all the time.
Effect of long - term,
alternate day feeding on renal function in aging conscious rats.
While
alternate -
day fasting leads to calorie restriction over a two -
day period in many rodent species, in some strains of mice, the animals managed to compensate for the calorie deficit created
on fast
days by increasing their intake
on feast
days twofold and thus keeping the total calorie intake over a two
day period at the same level as in mice
fed an ad libitum diet (17).
Furthermore, when myocardial infarction was induced in rats maintained
on an
alternate -
day fasting diet, reduced infarction size, improved cardiac function, and increased survival was observed, compared to rats
fed ad libitum (24,33,43).
Furthermore, in an animal model of Huntington's disease, prolonged survival, reduced disease - associated weight loss and improved motor function was observed in animals
on an
alternate -
day fasting diet compared to animals
fed ad libitum (49).
Anson et al. showed that mice
on alternate -
day fasting regimen who consume the same amount of food in a 48 - hour period as mice
fed ad libitum, decreased glucose and insulin concentrations to a similar degree as did mice
on daily calorie restriction despite maintained energy intake and body weight (17).
However, C57BL / 6 mice maintained
on the same
alternate -
day fasting regimen consume similar food quantities in a 48 - hour time period and maintain body weights similar to that of mice
fed ad libitum (17).
They propose that animals
on alternate -
day fasting diets increase life span compared to those
fed ad libitum (15,40).
When mice with progressive demyelinating disorders of the peripheral nervous system were put
on an
alternate -
day fasting diet regime, hampered disease progression was observed as indicated by improved nerve morphology and performance compared to mice
fed ad libitum (37).