Sentences with phrase «female carriers»

A total of 19581 female carriers of BRCA1 mutations and 11900 carriers of BRCA2 mutations were eligible for inclusion in this study.

Antonis C. Antoniou, Ph.D., of the University of Cambridge, England, and colleagues included 6,036 BRCA1 and 3,820 BRCA2 female carriers (5,046 unaffected and 4,810 with breast or ovarian cancer or both at study entry) in the analysis.

When the Edinburgh team bred male and female carrier mice, «A quarter of the offspring grew and developed just as if they had CF,» says Porteous.

In a 2011 paper, she reported that female carriers of a defect in SCARB1 had lower levels of progesterone than women without the mutation.

But even those with fewer repeats — both males and female carriers — are at risk for certain disorders later in life.

Female carriers of the mutation in the FMR1 gene often develop some symptoms of the disorder such as anxiety and depression that sometimes increase over time, said Warren.

The disease is inherited on the X chromosome and female carriers are healthy.

A female carrier for an X-linked recessive disease has a 50 % chance of passing on the variant in each pregnancy.

Female carriers have abnormal glomerular basement membrane as well, but usually remain healthy until later life when renal failure may occur.

However, the gene is transmitted through a female carrier who is often free of symptoms, or mildly affected with a limb weakness.