Sentences with word «fenfluramine»

Title: Confirmation of fenfluramine effect on 5 - HT1B receptor binding of [11C] AZ10419369 using an equilibrium approach Author: S. J. Finnema et al..

Neuroendocrine response to fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing

In 1997, the weight - loss drug fenfluramine was pulled from the market for causing heart - valve problems.

was adulterated with fenfluramine and phentermine (fen - phen), causing one death and severe liver damage in 14 others.

Benfluorex, produced by French pharmaceutical company Servier, is a member of a family of drugs called fenfluramines that suppress appetite.

Between 1997 and 2007, five weight - loss drugs were removed from various markets around the world due to safety or effectiveness considerations: phenylpropanolamine HCl, dexfenfluramine HCl (e.g., Redux), fenfluramine HCl (Pondimin), diethylpropion HCl (Tenuate), and phentermine HCl (e.g., Ionamin).

Two drugs, Pondimin and Redux, were yanked from the market in 1997 for the same reason as Fen - Phen (both contained forms of fenfluramine), and in 2007, a drug called rimonabant that had yet to be approved in the U.S. was withdrawn from FDA consideration and pulled from shelves in Europe due to reports of psychiatric side effects.

Adults with heightened levels of aggression and antisocial behaviour have been shown to have a reduced reaction to fenfluramine challenge (a test of serotonin function in the hypothalamic - pituitary - adrenal axis) in comparison with healthy controls [26], [27].

Serotonin - plus - adrenaline boosting therapies, the most prominent of which was fenfluramine - phentermine («fen - phen»), have tended to do better at cutting weight than serotonin - boosting therapies alone.

Unfortunately, the serotonin - boosting elements of these compounds have often been blamed for cardiovascular side effects — fenfluramine, for example, was banned by the FDA in 1997 — but in principle, future combination therapies could be designed to avoid producing such side effects.

Another member of the fenfluramine group, called dexfenfluramine and marketed by Servier under the name Isomeride, was pulled from the French market in 1997, after a 1996 study in The New England Journal of Medicine showed that it increased the risk of a dangerous condition called primary pulmonary hypertension.

Similar to fenfluramine, Belviq suppresses food cravings by mimicking the effects of serotonin in the brain, making people eat less and feel full.

Qnexa contains lower doses of phentermine than Fen - Phen did, however, and an FDA review of Qnexa noted that the «fen» part of the drug, fenfluramine, is believed to have been responsible for the heart valve problems.

A prospective case - controlled study found that there was a clear and significant correlation between appetite suppressant, «anorexia drug» fenfluramine and pulmonary hypertension (16).

The results showed that in those who had taken either fenfluramine and phentermine for four or more months, the cumulative incidence of idiopathic cardiac - valve disorders was 35.0 per 10,000 subjects.

Both fenfluramine and phentermine have at one time or another been implicated in higher risk stratification for cardiac valve disorders — in particular aortic and mitral valve insufficiency.

Redux, in particular, contains dexfenfluramine - the more potent portion of fenfluramine, which made up part of Fen - Phen, the popular drug cocktail.

Both fenfluramine and dexfenfluramine are now illegal in the US.

Interestingly, Halperin et al. [38] demonstrated that aggressive children with low - prolactin responses to fenfluramine challenge had significantly greater numbers of first - and second - degree relatives with aggressive and antisocial characteristics compared to both non-aggressive children and aggressive children with high - prolactin responses.

Low versus high prolactin responders to fenfluramine challenge: Marker of behavioral differences in adult male cynomolgus macaques