Not exact matches
Fetal stem
cells, which may turn out to be useful for treating conditions like Parkinson's, need to be cloned — that is,
researchers need to take a
cell from a body, put it in an embryo, and grow that embryo to a certain small size before harvesting the stem
cells.
The
researchers zapped each egg and
fetal cell with electricity to get them to fuse, then added a chemical mixture that inhibits enzyme activity to jump - start the biochemical machinery that produces an embryo.
Placentas had underdeveloped blood vessels, the barrier between mother and
fetal cells was abnormal, and
researchers spotted evidence of cellular stress.
Using these metrics, the
researchers saw signs of newborn nerve
cells in
fetal brains and brains from the first year of life, but they became rarer in older children.
In a series of laboratory experiments, the
researchers found that antibodies against HSV - 1 remain in the trigeminal ganglion (a group of nerve
cells that receives signals from the eyes and face and is a key site of HSV infection) long after active virus infection is cleared, and that these maternal antibodies can travel to the
fetal trigeminal ganglia.
For one thing,
researchers learned that
fetal T
cells are, in fact, able to reject foreign invaders — whether a microbe or a
cell transplant — more readily than thought.
Previous work has shown that
fetal cells can linger in the mother's blood and bone for decades, a condition
researchers call
fetal microchimerism.
«Research using human
fetal tissue is invaluable to scientific and medical communities worldwide that study and work on human development and disease,» said Hans Clevers, president of the International Society for Stem
Cell Research (ISSCR), and a stem cell researcher at Utrecht University in the Netherlands, in a statement released 14 J
Cell Research (ISSCR), and a stem
cell researcher at Utrecht University in the Netherlands, in a statement released 14 J
cell researcher at Utrecht University in the Netherlands, in a statement released 14 July.
Initially, the
researchers placed the fragments on a gel and soaked them in
fetal bovine serum, a typical ingredient of
cell cultures.
For example, to understand why a
fetal brain sometimes doesn't reach full size, a condition called microcephaly, the
researchers grew organoids using iPS
cells derived from a person with the condition.
For example, when the
researchers tested how the tissue responded to certain drugs that impair
fetal heart
cells but not adult heart
cells, the micro heart muscle performed more like adult heart tissue.
By analyzing human development, the
researchers found a
fetal skeletal muscle
cell that is extraordinarily regenerative.
Of the 29 early embryos created by somatic -
cell nuclear transfer and implanted into various ewes by Roslin
researchers, only one, Dolly, survived, suggesting that the technique currently has a high rate of embryonic and
fetal loss.
The
researchers found that the women with preeclampsia were more likely to have intact
fetal cells in their bloodstreams, and many more of them.
Neural stem
cell lines derived from human
fetal brain tissue achieved the same feats, the
researchers report in the October issue of Nature Neuroscience.
When the
researchers used
fetal breast tissue rather than adult tissue from mice, they were able to pinpoint which
cells were stem
cells but the
cells would rapidly change when grown in a dish.
In another set of experiments, the
researchers found that
fetal dendritic
cells could block the production of TNF - alpha by adult T
cells as well.
Researchers also discovered that a little bit of
fetal hemoglobin, just over 1 % of a person's total hemoglobin, generally courses through human veins our entire lives and that sickle
cell patients who have more than usual, over 15 %, have milder symptoms.
Studying a new type of pinhead - size, lab - grown brain made with technology first suggested by three high school students, Johns Hopkins
researchers have confirmed a key way in which Zika virus causes microcephaly and other damage in
fetal brains: by infecting specialized stem
cells that build its outer layer, the cortex.
Single -
cell RNA - Seq analysis also helped
researchers benchmark the engineered 3D liver tissues generated from stem
cells against naturally occurring human
fetal and adult liver
cells.
But, by focusing on tissue obtained from mouse embryos, the Salk
researchers were able for the first time to identify and isolate a sufficiently large number of
fetal breast stem
cells to begin to understand how their GPS works.
Though Diamond's lab has received federal funding, he said
researchers who have been cut out include those who study pregnancy,
fetal development or neural stem
cells.
In the study's first phase,
researchers examined the cellular content of
fetal mouse blood and found a large proportion of maternal blood
cells in the fetus.
Finally, the
researchers transplanted
fetal mice with blood stem
cells matched to the mother, which, as expected, resulted in a very high success rate.
Researchers at Harvard - affiliated McLean Hospital have found that
fetal dopamine
cells transplanted into the brains of patients with Parkinson's disease were able to remain healthy and functional for up to 14 years, a finding that could lead to new and better therapies for the illness.
The Swedish part of the effort, called the Human Developmental
Cell Atlas (HDCA) program, includes
researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and
fetal development during the first 12 -LSB-...]
The Zika virus is known to negatively impact the growth of
fetal brains and a group of
researchers publishing in the journal
Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferat
Cell Stem
Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferat
Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to
cell death and reduced proliferat
cell death and reduced proliferation.
«We're showing that in the context of maternal infection or inflammation — the most common cause of preterm labor — the naive
fetal immune system wakes up, gets activated too early, and can actually identify and reject the mother's
cells,» said lead
researcher Dr. Tippi MacKenzie.