Sentences with phrase «fibrils by neurons»
The cell culture experiments showed that MAbs prevented the uptake of misfolded α - syn fibrils by neurons and sharply reduced the recruitment of natural α - syn into new Lewy body aggregates.
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Whereas PD motor symptoms are driven by loss of dopamine - producing neurons, many of the nonmotor symptoms are instead linked to the accumulation of Lewy bodies and other malformed clumps and fibrils of the protein alpha - synuclein (AS) inside and between neurons.