Sentences with phrase «fibrils when»

Thus far, each one has proved capable of forming fibrils when heated or immersed in a solution containing acid or a form of alcohol.

Not exact matches

When myocilin goes wrong, or «misfolds,» it makes fibrils that damage tissue called the trabecular meshwork that normally allows the fluid inside the eye to drain and relieve interior pressure.

«When a myocilin propellor misfolds, it unravels and forms amyloid fibrils (stringy abnormal proteins) that kill cells that maintain the trabecular network,» Lieberman said.

And since the fibrils they form when misfolded are strong, scientists believe that hope primarily lies not in dismantling them, but in heading off the folding errors.

They discovered that when α - synuclein fibrils are broken down, it often creates a smaller protein clump, which they named pα - syn * (pronounced «P - alpha - syn - star»).

For intervention studies, they treated PD mice with Syn303 several days after fibril injections when Lewy bodies were already present.

(10) The company's scientists also report that when they then injected preformed AS fibrils into the brains of mice, BIIB054 slowed the self - templating spread of AS pathology across the brain (consistent with their cell - culture study), and held much of the ensuing motor dysfunction at bay (9,10)(reducing it «by more than 50 percent» according to a science journalist who was present when they presented results at AD / PD 2017 (11)-RRB-.

These reagents, prepared against human light chain - related fibrils, recognize an epitope common to the beta - pleated structure of AL and other types of amyloid proteins and can effect rapid amyloidolysis when administered to mice injected with human AL amyloid extracts.