Sentences with word «fibroblast»
A fibroblast is a type of cell in our bodies that helps to produce and maintain the structures that hold our tissues together. Full definition
Maria Kolanczyk (Brand, TUD)-- «Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish» (2009)
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It spurred the fastest growth of fibroblast cells, with 17 per cent more cells formed after six days as in a control culture.
They also found that antibodies from Graves patients activated IGF - 1 receptors in fibroblasts from rheumatoid arthritis patients (and vice versa), triggering chemokine production and T cell migration.
They have already shown that they can transform human fibroblast cells into pluripotent stem cells, and now plan to start working on delivering the proteins needed to differentiate stem cells into specialized tissues.
Replication of Toxoplasma gondii, but Not Trypanosoma cruzi, Is Regulated in Human Fibroblasts Activated with Gamma Interferon: Requirement of a Functional JAK / STAT Pathway
Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.
• In March, a University of Wisconsin team reprogrammed skin fibroblasts into embryonic stem cells without incorporating the viral or other foreign DNA that can lead to complications like cancer.
The experiment shows that β1 - integrin — one of 28 types of integrin — maintains a link between the stem cell and its environment, and interacts biochemically with a growth factor called fibroblast growth factor [FGF] to promote stem cell growth and restoration after muscle tissue injury.
Shi, Y.; Desponts, C.; Do, J. T.; Hahm, H. S.; Scholer, H. R.; Ding, S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small - molecule compounds.
The potential of iPS cells to help treat everything from damaged heart tissue to Parkinson's disease, has prompted intensive research that has looked into the use of skin fibroblast cells as an alternative to controversial embryonic stem cells.
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.
Biaxially stretched poly (epsilon - caprolactone) films as matrices in human dermal fibroblast cultures.
Four genes were disrupted simultaneously in goat fibroblasts by CRISPR / Cas9 - mediated genome editing.
Primary bile acid diarrhea, or BAD, in humans has been shown to be related to the hormone known as fibroblast growth factor 19.
Development of a bioengineered model to quantitatively measure the tumorigenic properties of cancer - associated fibroblasts in human prostate cancer.
«We are now trying to make adult cardiac fibroblasts more like their embryonic counterparts to induce cardiomyocyte proliferation in the adult.»
The research team, spearheaded by postdoctoral fellow Yajie Liang, Ph.D., wondered whether the cells» survival could also be enhanced with steady doses of a compound called basic fibroblast growth factor (bFGF), an «energy drink» that spurs cells to grow.
The generation of induced pluripotent stem cells from adult fibroblast cells to create iPS cells.
This induced pluripotent stem cell (iPSC) line was generated from IMR90 fetal lung fibroblasts by viral transduction of a combination of OCT4, SOX2, NANOG, and LIN28 genes.
Total RNA was extracted from the cerebellar cultures at 14 and 16 DIV and renal fibroblast cultures using the RNeasy Mini Kit (Qiagen, Tokyo, Japan).
In this study, we have investigated the short - term biological responses of ROCKi to human primary foreskin fibroblasts.
The TGF beta - 1 was produced by the stromal fibroblasts which surrounded the tumour cells.
This will be followed by an overview over the achievements during the last few years of converting fibroblasts into induced neurons; a line of research that has gained considerable momentum.
The systematic characterization of somatic mutations fed nicely into a phylogenetic analysis, which revealed that all d42m1 derived clones were related (genetically speaking) to one another, while quite distinct from the other sarcoma (H31m1) as well as normal fibroblast cells.
Review of «Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration» from Stem Cells by Stuart P. Atkinson
Nintedanib, in addition to blocking vascular endothelial growth factor receptors (VEGFR) and platelet derived growth factor receptors (PDGFR), also acts on fibroblast growth factor receptors (FGFR), which makes it different to classical angiogenesis inhibitors.
«Twin expression profiling identifies cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled Rheumatoid Arthritis»
Individual cultures of 3T3 (a murine fibroblast line) and endothelioma cells subjected to identical treatment were used for negative and positive controls, respectively.
Recently, Dr. Ding achieved entirely gene - free chemical reprogramming, using only drugs to turn fibroblasts directly into brain cells.
In thyroid eye disease (TED), orbital fibroblasts form contractile myofibroblasts that secrete high levels of collagen and lead to destructive tissue remodeling.
The team also transplanted treated fibroblasts into the hearts of live mice, where they developed into cardiomyocytes (Cell, DOI: 10.1016 / j.cell.2010.07.002).
(A) Design and activity of Cas9 / gRNAs in goat fibroblasts.
Faster Wound Healing Laser light stimulates fibroblast development.
Indeed, it was shown that Oct4 and Klf4 could reprogram murine NSCs at an efficiency of 0.11 %, similar to the reprogramming rate of murine fibroblasts with the original four factors with antibiotic selection [14].
The team also tested nanoparticle absorption for other kinds of human cells, including fibroblasts from donors of older ages and found significant differences.
Cells with average speed represented cells with a spindle - like fibroblast shape, medium size, and a percentage of senescent cells in - between the fast and slow population.
In renal fibroblast cultures, however, mRNAs of the α3, α4, and α7 nAChR subunits were not expressed.
«Advanced Cell Technology has the ability to produce transgenic animals using fetal fibroblast nuclear transfer,» claims Steve Parkinson, president and chief executive officer.
In future research supported by the National Institutes of Health, the researchers will study exactly how mucosal fibroblasts make immune cells more «infectable», which could ultimately lead to new targets for preventing HIV.
Similar to how boron activates the osteoblasts in the bones, it also activates fibroblasts of the skin and tissues.
A structure containing interstitial fibroblast - like cells developed within the WAT in sexually immature migratory adults.
Greco RM, et al., «Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix,» J Cell Physiol 177 (3): 465 - 73 (1998).
In 1987, a group reported using MyoD to make fibroblasts become muscle cells (Davis et al., 1987).
Two research groups have devised small - molecule recipes to directly transform fibroblasts into neurons.
Roberts, E. W. and Deonarine, A. and Jones, J. O. and Denton, A. E. and Feig, C. and Lyons, S. K. and Espeli, M. and Kraman, M. and McKenna, B. and Wells, R. J. B. and Zhao, Q. and Caballero, O. L. and Larder, R. and Coll, A. P. and O'Rahilly, S. and Brindle, K. M. and Teichmann, S. A. and Tuveson, D. A. and Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein - alpha from skeletal muscle and bone marrow results in cachexia and anemia.