Sentences with phrase «fibroblasts become»

Not exact matches

One found that a chemical compound caused valve fibroblasts to become active, similar to what is observed during valve disease, but the other study indicated that the same compound prevented the cells from calcifying, indicating that a key piece of the valve disease puzzle was missing.

The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.

«It's abdominal obesity, and even more specifically, levels of a protein called fibroblast growth factor - 2 that may be a better indicator of the risk of cells becoming cancerous.»

When he added all four genes, about 0.01 percent of the skin - cell fibroblasts eventually became iPS cells but about 0.2 percent of the fat stem cells did so — a 20-fold improvement in efficiency.

Dr. Ding's work revolves around chemical reprogramming — the use of small molecule drug mixtures to coax fibroblasts into becoming a variety of other cell types.

Unlike highly specialized skin - cell fibroblasts, these cells in the fat have a relatively wide portfolio of differentiation options — becoming fat, bone or muscle as needed.

In his laboratory mice, Dr. Ding has now used chemical reprogramming to turn fibroblasts into neural «precursor» cells with the potential to become new oligodendrocytes.

Yamanaka's group used human adult dermal fibroblasts and induced them to become iPSCs, appearing and functioning like hESCs, by having them express the same proteins as he used with mouse cells: Oct - 4, Sox2, Klf4, and c - Myc (Takahashi et al., 2007).

They made adult fibroblastic mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the fibroblasts to express four key embryonic stem cell factors: Oct - 4, Sox2, Klf4, and c - Myc.

«Half of the cells in the heart are fibroblasts, so the ability to call upon this reservoir of cells already in the organ to become beating heart cells has tremendous promise for cardiac regeneration.

In research published in the current issue of Cell, scientists in the laboratory of GICD director Deepak Srivastava, MD, directly reprogrammed structural cells called fibroblasts in the heart to become beating heart cells called cardiomyocytes.

If blood pressure is high enough to provoke fibroblasts to become myofibroblasts, the cells also may get stuck in their helper state.

The researchers then successfully prodded what they call keratinocyte - derived iPS cells or KiPS cells to distinguish them from fibroblast - derived iPS cells into becoming all the cell types in the human body, including heart muscle cells and dopamine - producing neurons, which are affected by Parkinson's disease.

The question becomes who is invading whom — do cancer cells invade the basement membrane or do some fibroblasts help invading cancers?

The endothelial cells became vessels, recruited fibroblasts and caused them to differentiate into smooth muscle cells.

At the same time, the protein Vascular Endothelial Growth Factor (VEGF) stimulates blood supply for the damaged tissue, Fibroblast Growth Factor - 2 (FGF - 2) stimulates the damaged cells to grow and reproduce themselves, Transforming Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem Cell Factor (SCF) stimulates your native inactive stem cells to become activated and assist in the repair of the damaged tissue.