The gelatinolytic assays were carried out in two different ways to obtain complementary information: firstly, cells were treated or not with the test compound and samples from these were submitted to gelatinase zymography to detect the effects of the kahweol treatment on the expression of gelatinase activities; secondly, in some experiments, samples from control, untreated HT - 1080
fibrosarcoma cells were submitted to zymography and, after electrophoresis, different concentrations of kahweol were added to the substrate buffer to determine the potential direct effect of kahweol on gelatinase activity.
HT - 1080
fibrosarcoma cells were supplied by ATCC and maintained in culture as described by the provider.
Not exact matches
In
fibrosarcoma and neuroblastoma
cells, huntingtin shows discrete punctate, perinuclear localization overlapping largely with the trans - Golgi and cytoplasmic clathrin - coated vesicles, implicating huntingtin in vesicle trafficking.
Among the common canine and feline skin tumors are mast
cell tumors, perianal adenomas,
fibrosarcomas, melanomas, histiocytomas, squamous
cell carcinomas, hemangiopericytomas, and basal
cell tumors.
Approximately two - thirds of all canine nasal tumors are carcinomas, including adenocarcinoma, squamous
cell carcinoma and undifferentiated carcinoma; and one - third sarcomas, including
fibrosarcoma, chondrosarcoma, osteosarcoma, and undifferentiated sarcoma.
Other primary bone tumors include chondrosarcoma, hemangiosarcoma,
fibrosarcoma, lymphoma and plasma
cell tumors.
Common oral tumors for both dogs and cats are squamous
cell carcinoma,
fibrosarcomas, and malignant melanomas1.
Some of the most common are lymphoma, osteosarcoma, transitional
cell carcinoma, mammary gland carcinoma, mast
cell tumor, melanoma,
fibrosarcoma and leukemia, among others.
Below are some of the common specialty areas that we have experience with: - Infectious diseases: Tick - borne disease (Lyme disease, Ehrlichiosis, Rocky Mountain Spotted Fever, Bartonella), systemic and local bacterial infections, feline and canine viral disease - Hematology: Immune - mediated hemolytic anemia, thrombocytopenia, leukemia, bone marrow diseases - Oncology: Surgical and chemotherapy management, lymphoma, mast
cell tumors, hemangiosarcoma, osteosarcoma,
fibrosarcoma, mammary neoplasia, as well as benign and malignant skin masses such as adenomas and cysts - Urology: Kidney failure, bladder infections, stones / crystals, prostatic disease, pyelonephritis, FLUTD, protein - losing nephropathy, glomerulonephritis - Endocrine: Hormonal diseases such as hyper - and hypothyroidism, diabetes mellitus, cushings disease, addison's disease, endocrine skin disease - Gastroenterology: Chronic vomiting and / or diarrhea, inflammatory bowel disease (IBD), stomach ulcers / gastritis, colitis, pancreatic disorders, liver disease, protein - losing enteropathy - Respiratory disease: Feline asthma, canine chronic bronchitis, upper respiratory viral disease, pleural effusion, laryngeal paralysis - Cardiology: Heart murmurs and arrhythmias, heart failure, heartworm disease, hypertension - Ophthalmology: Gaucoma, cataracts, uveitis, corneal disease, ocular surgery - Allergic disease: Allergic dermatitis, food allergies, flea allergy, and allergic gastrointestinal and respiratory disease
Other tumors and cancers found regularly in Bernese Mountain Dogs are mast
cell tumors, lymphosarcoma, osteosarcoma, hemangiosarcoma, and
fibrosarcoma.
Golden Retriever — Mast
cell tumor, Sweat gland tumor, Trichoepithelioma, Melanoma, Haemangioma, Histiocytoma, Fibroma, Lymphosarcoma, Nasal cavity tumors, Thyroid neoplasia, Insulinoma, Primary brain tumor,
Fibrosarcoma
They include squamous
cell carcinomas, adenocarcinomas,
fibrosarcomas and melanomas.
Cats are most commonly diagnosed with squamous
cell carcinomas followed by
fibrosarcomas.
Dogs are most commonly diagnosed, in decreasing frequency, with malignant melanomas, squamous
cell carcinomas, and
fibrosarcomas.
Other types of bone cancers include synovial
cell sarcoma, hemangiosarcoma, chondrosarcoma and
fibrosarcoma.
SECTION 2: SELECTED TOPICS ON CLINICAL PATHOLOGY Adenocarcinoma Behavioral Problems Canine Hip Dysplasia Ear Infections (Otitis) Epilepsy
Fibrosarcoma Gastric Dilation - Volvulus (GDV) or Bloat Hemangiosarcoma Hypothyrodism Lymphoma Malignant Histiocytosis Mast
Cell Tumors Melanoma Nonmalignant Tumors of the Skin and Soft Tissues Osteochondrosis Osteosarcoma Patellar Luxation
Other less common tumors that cause canine stomach cancer include gastrointestinal stromal tumors, leiomyosarcomas, lymphomas, mast
cell tumors, extramedullary plasmacytomas, and
fibrosarcomas.
Malignant tumors including oral melanoma,
fibrosarcoma, squamous
cell carcinoma, and oral osteosarcoma and can be found in both dogs and cats.