Most people with cystic
fibrosis develop lung infections that involve multiple species of microbes.
Not exact matches
Despite much effort, no one has managed to
develop an effective form of gene therapy to treat the
lung problems of people with cystic
fibrosis.
Researchers have
developed a new approach for growing and studying cells they hope one day will lead to curing
lung diseases such as cystic
fibrosis through «personalized medicine.»
One of the most dangerous of these bacteria is P. aeruginosa, which, within the unique mucus that forms in the
lungs of a person with cystic
fibrosis,
develops into large, antibiotic - resistant colonies.
Since the discovery of the genetic basis for cystic
fibrosis in 1989, scientists have
developed a variety of viral and non-viral vector systems for delivering a corrected CFTR gene back into
lung cells.
The first of many probable applications will likely be the chronic bacterial infections in the
lungs of cystic
fibrosis patients «that frequently
develop resistance to all standard antibiotics, and are the leading cause of death in these patients,» says senior author Ronald Montelaro.
It might be possible, Schonwetter speculates, to
develop aerosols containing an LAP - like antiseptic that could be inhaled by cystic
fibrosis sufferers to help them fight off
lung infections.
In the converse experiment, the group showed that when increasing lipid production in
lungs of animals already injured and
developing pulmonary
fibrosis,
lung scarring could be reduced by 70 - 80 percent.
Dr. Summer and colleagues are currently working to
develop a therapy that could restore lipid production in the
lungs of pulmonary
fibrosis patients and slow the fibrotic process.
Yale University researchers are studying a potential new treatment that reverses the effects of pulmonary
fibrosis, a respiratory disease in which scars
develop in the
lungs and severely hamper breathing.
Using translational research methods, the DZL seeks to jointly
develop new approaches for the prevention, diagnosis and therapy of serious
lung diseases including asthma, chronic obstructive pulmonary disease (COPD), cystic
fibrosis, diffuse parenchymal
lung disease (DPLD), endstage
lung disease,
lung cancer, pneumonia and acute
lung injury, and pulmonary hypertension.
A team of scientists from the UNC School of Medicine and North Carolina State University (NCSU) has
developed promising research towards a possible stem cell treatment for several
lung conditions, such as idiopathic pulmonary
fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic
fibrosis — often - fatal conditions that affect tens of millions of Americans.
Some patients also
develop scarring or
fibrosis at the top of the
lungs, thus making it harder to ward off viruses and infections.