Sentences with word «fibrotic»

Wnt / β - catenin has been shown to play a crucial role in other fibrotic diseases such as pulmonary fibrosis and hypertrophic scar formation.

The lymph rich - protein content is unable to move, and it hardens, generating fibrotic tissues and over time calcification in the tissues around it.

To develop strategies for preventing or reducing fibrosis, Michael Freeman, Ph.D., and colleagues are exploring the cell types and factors that contribute to the radiation - induced fibrotic response.

In areas where there is a selenium deficiency, use of rapeseed oil has been associated with a high incidence of fibrotic lesions of the heart, called Keshan's disease.20 The animal studies carried out over the past twenty years suggest that when rapeseed oil is used in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnified.

Co-precipitating of fibrotic lesions as demonstrated by collagen expression in acinar cells may be attributed to defence mechanism against inflammatory cytokine - induced pancreatic injury and inflammation [26]; interestingly, the collagen expression was restored when pancreatic inflammation was relieved [46].

It also helps increase production of glutathione, the liver's main antioxidant and «detoxifier» and protects against fibrotic changes in the liver.

Studies of this anti-fibrotic agent in people with fibrotic liver disease show remarkable improvement in symptoms and survival rates.

In specific aim II, the role of miR - 24 and its target proteins in inflammatory and fibrotic processes in CNV are being assessed.

Also, the ANGPTL4 protein could be useful for other fibrotic diseases such as keloids.

Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules, leading to progressive loss of liver function.

«There could be potential long - term therapeutic treatments that could arise from this new knowledge, which can be explored for the treatment of additional fibrotic disorders including kidney disease.»

«Our data are a strong proof of principle and the first to show that inhibiting fibronectin polymerization preserves heart function, reduces left ventricle remodeling and limits formation of fibrotic connective tissue,» said lead investigator of the study and director of translational research in the Heart Institute and the Center for Translational Fibrosis Research.

On a broader scale, the study identifies a novel pathway by which HSC activation and regression are regulated, which could potentially be applied to other aging - associated fibrotic liver diseases.

Unfortunately, about two - thirds of the mono - unsaturated fatty acids in rapeseed oil are erucic acid, a 22 - carbon monounsaturated fatty acid that had been associated with Keshan's disease, characterized by fibrotic lesions of the heart.

Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver diseases, with particular emphasis on different therapeutic modalities for pathway modulation.

When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury.

We are interested in three classes of proteins; one which is responsible for the hardening of the cells and their surrounding environment (these are known as fibrotic proteins) in glaucoma and the other which regulates the level of calcium entering and exiting cells.

Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially in systemic sclerosis (SSc), a disease in which pDCs infiltrate fibrotic skin lesions and produce higher levels of IFNα as compared to healthy controls.

Otherwise, the lymph fluid progressively hardens, generating fibrotic tissues and calcification.

Avoiding fibrotic tissue could mean the difference between regenerating and not: Mouse nerves grow vigorously if experimentally severed in a way that prevents scarring, but if a scar forms, nerves wither.

What we have discovered is that by acting on the genome, VDR can simultaneously defend against multiple fibrotic activators.

On the contrary, senescence is decreased in activated hepatic stellate cells (HSCs), the supportive cells which, when triggered by alcohol or other liver insults, begin to produce excessive fibrotic material.

The problem arises in this case from a faulty fibrotic conversion and enlargement of the heart.

The finding adds further credence to a current pharmaceutical effort to create new treatments for diabetic nephropathy, liver fibrosis and other progressive fibrotic and inflammatory diseases, based on blocking these two molecules, both members of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) family of proteins.

Brenner's 2012 study, in mouse models of liver fibrosis, found that treatment with the GKT137831 NOX inhibitor suppressed ROS production and HSC activation and reduced fibrotic gene expression.

To compensate for this stress, liver cells proliferate and turn fibrotic over time.

«This is the first paper to show that rather than being a «second hit» to help initiate the disease, blocking lipid synthesis alone — with no other insult to the lungs — can instigate fibrotic scaring,» said Ross Summer Professor of Medicine at Thomas Jefferson University and physician - researcher in the Jane and Leonard Korman Respiratory Institute.

Cellular senescence mediates fibrotic pulmonary disease.

Chronic Bile Duct Injury Associated with Fibrotic Matrix Microenvironment Provokes Cholangiocarcinoma in p53 - Deficient Mice

So Nagatomi recommends intense training, but less frequently - perhaps every other day instead of daily - to avoid developing fibrotic changes.

One study of Chinese children consuming rapeseed oil indicated an association with Keshan's disease, which causes fibrotic lesions on the heart (2).

In addition, don't forget, systemic enzymes which are extremely helpful for breaking down fibrotic plaque and lowering inflammatory proteins like CRP.

FLO a Golden Retriever, female, one and a half year old with a severe pulmonary stenosis withhypoplastic wide fibrotic subvalvular component.

Muscle inflammation due to many autoimmune diseases (Masticatory myositis, Eosinophilic Myositis, Polymyositis, Myositis Ossificans, Fibrotic myopathy, etc.) can be the cause of high CK blood levels — particularly early in the disease or during flareups.

It's time we began to learn about its role in fibrotic scarring of the lens in cataract formation and other diseases.»

With more than 18 years of experience in drug discovery working on molecular mechanisms underlying monogenic and multigenic metabolic and fibrotic disorders as well as hematologic malignancies, Dr. Martini's laboratory is focused on identifying novel therapies and applying translational approaches for drug development in rare genetic disorders.

Chronic GVHD is characterized by autoimmune - like, fibrotic changes in multiple organs such as the skin (causing scleroderma) and the lungs (causing bronchiolitis obliterans), and fibrosis of the salivary glands, liver, and gut.

Occasionally, an overgrowth of Demodex mites may be missed even with properly performed skin scrapings and hair plucks, especially in dogs with thickened or fibrotic skin due to chronic dermatitis or because of their breed (i.e. Shar - Peis, bulldogs).

High levels of heart disease are associated with selenium - deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China.

The compound is now in phase II clinical trials for diabetic nephropathy and is being explored in other fibrotic diseases.

So, fibrotic tissue shows up.