Sentences with phrase «fibrotic diseases»
"Fibrotic diseases" refers to a group of medical conditions characterized by the formation of excess fibrous tissue in the body. This tissue development can lead to the scarring and hardening of organs or tissues, causing them to lose their normal function. Full definition
Wnt / β - catenin has been shown to play a crucial role in other fibrotic diseases such as pulmonary fibrosis and hypertrophic scar formation.
sciencedaily.com
Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.
Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial / mesenchymal phenotypes: implications for treatment of fibrotic diseases.
Salk researchers found that a drug already approved by the FDA for the treatment of psoriasis deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.
Also, the ANGPTL4 protein could be useful for other fibrotic diseases such as keloids.
Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver diseases, with particular emphasis on different therapeutic modalities for pathway modulation.
The company's biopharmaceutical research and development efforts in the affective (psychiatric) disorders, Alzheimer's / dementia, cardiovascular, diabetes, hepatitis, HIV / Acquired Immunodeficiency Syndrome (AIDS), oncology, immunologic disorders and fibrotic disease areas.
«In the future, these results could also lead to new therapeutic options for the treatment of other fibrotic diseases.»
The firm dropped discovery and development in the areas of diabetes, virology, and neuroscience in favor of a research focus on oncology, heart failure, genetically defined diseases, immunoscience, and fibrotic diseases.
The compound is now in phase II clinical trials for diabetic nephropathy and is being explored in other fibrotic diseases.
«We've found that these Gli1 progenitor cells differentiate into myofibroblasts, and in fibrotic disease, when they are ablated, we can rescue organs and organ function,» said Humphreys.
Fibrotic diseases, such as chronic kidney disease and failure, lung disease, heart failure and cirrhosis of the liver, are estimated to be responsible for up to 45 percent of deaths in the developed world.
NorthSea Therapeutics develops therapeutics for NASH and other metabolic, inflammatory and fibrotic diseases.