Salk researchers found that a drug already approved by the FDA for the treatment of psoriasis deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for
fibrotic diseases in humans.
Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for
fibrotic diseases in humans.
Not exact matches
It's time we began to learn about its role
in fibrotic scarring of the lens
in cataract formation and other
diseases.»
The firm dropped discovery and development
in the areas of diabetes, virology, and neuroscience
in favor of a research focus on oncology, heart failure, genetically defined
diseases, immunoscience, and
fibrotic diseases.
The compound is now
in phase II clinical trials for diabetic nephropathy and is being explored
in other
fibrotic diseases.
«
In the future, these results could also lead to new therapeutic options for the treatment of other
fibrotic diseases.»
Fibrotic diseases, such as chronic kidney
disease and failure, lung
disease, heart failure and cirrhosis of the liver, are estimated to be responsible for up to 45 percent of deaths
in the developed world.
Previously Dr. Martini worked at Shire plc
in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on
fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver
diseases, with particular emphasis on different therapeutic modalities for pathway modulation.
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells
in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
in aging mice and mouse models of age - related
disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10
In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11
in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201
in aging mice to near youthful norms, and prevented or treated mouse models of
diseases of aging like osteoarthritis, 12
fibrotic lung
disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related
diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin
in 201
in 2019.
These
fibrotic processes, nowadays more frequently detected, may be related to defects
in the repair process and / or to an increased incidence of autoimmune
diseases due to ageing.
Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially
in systemic sclerosis (SSc), a
disease in which pDCs infiltrate
fibrotic skin lesions and produce higher levels of IFNα as compared to healthy controls.
High levels of heart
disease are associated with selenium - deficient soil
in Finland and a tendency to
fibrotic heart lesions is associated with selenium deficiency
in parts of China.
Unfortunately, about two - thirds of the mono - unsaturated fatty acids
in rapeseed oil are erucic acid, a 22 - carbon monounsaturated fatty acid that had been associated with Keshan's
disease, characterized by
fibrotic lesions of the heart.
In areas where there is a selenium deficiency, use of rapeseed oil has been associated with a high incidence of fibrotic lesions of the heart, called Keshan's disease.20 The animal studies carried out over the past twenty years suggest that when rapeseed oil is used in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnifie
In areas where there is a selenium deficiency, use of rapeseed oil has been associated with a high incidence of
fibrotic lesions of the heart, called Keshan's
disease.20 The animal studies carried out over the past twenty years suggest that when rapeseed oil is used
in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnifie
in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnified.
The company's biopharmaceutical research and development efforts
in the affective (psychiatric) disorders, Alzheimer's / dementia, cardiovascular, diabetes, hepatitis, HIV / Acquired Immunodeficiency Syndrome (AIDS), oncology, immunologic disorders and
fibrotic disease areas.
Muscle inflammation due to many autoimmune
diseases (Masticatory myositis, Eosinophilic Myositis, Polymyositis, Myositis Ossificans,
Fibrotic myopathy, etc.) can be the cause of high CK blood levels — particularly early
in the
disease or during flareups.