In areas where there is a selenium deficiency, use of rapeseed oil has been associated with a high incidence of
fibrotic lesions of the heart, called Keshan's disease.20 The animal studies carried out over the past twenty years suggest that when rapeseed oil is used in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnified.
Unfortunately, about two - thirds of the mono - unsaturated fatty acids in rapeseed oil are erucic acid, a 22 - carbon monounsaturated fatty acid that had been associated with Keshan's disease, characterized by
fibrotic lesions of the heart.
One study of Chinese children consuming rapeseed oil indicated an association with Keshan's disease, which causes
fibrotic lesions on the heart (2).
These observations do illustrate for the characteristic of AP and chronic pancreatitis like changes exemplified with
fibrotic lesions [26].
Co-precipitating of
fibrotic lesions as demonstrated by collagen expression in acinar cells may be attributed to defence mechanism against inflammatory cytokine - induced pancreatic injury and inflammation [26]; interestingly, the collagen expression was restored when pancreatic inflammation was relieved [46].
Not exact matches
Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially in systemic sclerosis (SSc), a disease in which pDCs infiltrate
fibrotic skin
lesions and produce higher levels of IFNα as compared to healthy controls.
High levels of heart disease are associated with selenium - deficient soil in Finland and a tendency to
fibrotic heart
lesions is associated with selenium deficiency in parts of China.
Rape seed is unsuited to human consumption because it contains a very - long - chain fatty acid called erucic acid, which under some circumstances is associated with
fibrotic heart
lesions.