Not exact matches
On its own, this immune response had no immediate effect
in the
fight against the utilized breast
tumors, but
in combination with the ADC it proved itself effective
in attacking cancer cells
in mice, resulting
in the complete cure of the majority of
mice receiving the combination therapy.
The
mouse model could also contribute to the further development of immunotherapies — a method
in which the body's immune system is stimulated, so that it intensifies its
fight against
tumor cells.
Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the
mouse receptor genes on these T cells and monitor
in a dish both how those cells now
fight the
tumor and react to healthy human tissue.
The CRISPR - Cas9 genome editing system could help
fight cancer, and now, researchers have used the tool to target what they call cancer's command center,
in a treatment that's been shown
in mice to shrink aggressive
tumors and increase survival rates, without harming healthy cells.
They showed that T cells
in mice that could not make PSGL - 1 delayed
tumor growth, suggesting that blocking PSGL - 1's function would help T cells
fight tumors.
However, other studies
in mice with breast cancer show that once cancer has already been initiated, stress can lead to increased rates of
tumor spread and metastases.26 Similarly, when
mice were injected with leukemic cells and stressed physically and physiologically with injections of adrenaline, cancer progression occurred.27 Some scientists even propose that, while necessary
in many cases of cancer, undergoing surgery may cause enough stress to lead to
tumor promotion and progression.28 Therefore, it seems like acute stress may help
fight cancer, chronic stress may help cause it, but once cancer is present, both acute and chronic stress may lead to cancer progression.
First tested
in mice, the vaccine's purpose is to encourage the animals to make disease -
fighting antibodies to attack a
tumor.