Use of this technology to exclude patients from ivermectin - based treatment at the point of care in Loa - endemic regions would allow resumption / expansion of mass drug administration programs for onchocerciasis and lymphatic
filariasis in Central Africa.
Not exact matches
But the system has seen success
in some areas recently, like limiting the spread of HIV and lymphatic
filariasis.
On Monday, the 2015 Nobel Prize
in Physiology or Medicine went to William Campbell of Drew University
in Madison, New Jersey, and AAAS member Satoshi Ōmura of Kitasato University
in Tokyo, who will share half the prize for discovering the drug avermectin, which has been used to treat river blindness and lymphatic
filariasis as well as other parasitic diseases.
Urbanization and the resulting shrinkage of green spaces
in cities can be considered a boon for mosquitoes that transmit diseases, such as Aedes aegypti (dengue) and Culex quinquefasciatus (lymphatic
filariasis).
Clinical samples from two groups of individuals from the south Pacific island of Mauke and from Ecuador — one group infected with filarial worms causing lymphatic
filariasis and a second group infected with intestinal roundworms Ascaris — revealed increased levels of resistin
in the infected individuals compared to those who were uninfected or immune.
Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic
filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms
in younger children.
In the Culex pipiens mosquito group (including the
filariasis vector C. quinquefasciatus) a very unusual degree of complexity of Wolbachia - induced crossing - types has been reported, with partial or complete CI that can be unidirectional or bidirectional, yet no Wolbachia strain variation was found.
Evaluating the efficacy of repurposed small molecule inhibitors
in treating
filariasis using preclinical and clinical studies
In 1998, Merck expanded the program to include the elimination of another disease, lymphatic
filariasis.