Sentences with phrase «find candidate genes»

Our goal is to find candidate genes affecting primary hypertension.

Not exact matches

The Republican candidate, Gene DeFrancis, is a United States Navy veteran who founded a merchants association.

So Beller's team looked for just such a cluster of genes among the candidate genes in the toluenemaking sewage sample, and they found the GRE phenylacetate decarboxylase (PhdB) and its activator, PhdA.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

After demonstrating the existence of several genes that control indefinite cell division, she, a grad student named Yi Ning, and their colleagues found a candidate for one of those genes on chromosome 4.

«We're generating so much sequence data right now, from so many species, that it's relatively straightforward to look for signatures of selection in genes and to find good candidates for adaptations,» Montooth said.

«These findings illustrate how resurrection plants manipulate sugar metabolism to promote desiccation tolerance and may provide candidate genes that are potentially useful for the development of stress tolerant crops.»

When they found a good candidate that could deliver genes to rat brain cancer cells, they filled the nanoparticles with DNA encoding an enzyme, herpes simplex virus type 1 thymidine kinase (HSVtk), which turns a compound with little effect into a potent therapy that kills brain cancer cells.

A traditional way to target a candidate gene is to identify a molecule or process important to, say, emotion, and then go back and find the genes that control it.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

They confirmed the location for one fungal gene involved in the disease, AVRHt1, and found a candidate location for another, AVRHt2.

They found three candidate genes that they knew were involved in neural signaling for appetite, anxiety, and depression.

«These findings suggest that focusing on genes with conserved expression levels among primates may be helpful in identifying promising candidates for disease - association studies,» the researchers write.

Now, geneticist Bing Su of the Kunming Institute of Zoology in China and colleagues believe they have found another candidate by comparing the evolution of gene sequences across a menagerie of animals.

Graduate student Yu - Hsiang Tu then tested candidate genes one - by - one until he found one that produced a proton - conducting protein when introduced into cells that did not have any proton - conducting channels.

They found that the associated regions contained numerous candidate genes, among them genes known to affect ear function, language development, memory, bird song and the brain's reward mechanism.

Furthermore, high - resolution analysis of cytosine methylation in primary and transformed cells has found less aberrant methylation of CpG island promoters in transformed cells than had been previously hypothesized based on candidate gene studies [58].

Umarova, A., Garcia, A., and Linder C. Finding the gene for repro29 infertile mice: Zcchc8 candidate gene sequencing.

In a study published January in the journal Molecular Biology and Evolution, Gibbs and his team compared the DNA of the fat fruit flies to a control group in the lab and found nearly 400 candidate genes potentially associated with obesity and other health problems.

To find out if such a gene - environment interaction is involved, they first identified a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.

We found differential methylation in 123 sites (q < 0.15) representing 50 T2D candidate genes including IRS1, PPARG, KCNQ1, and TCF7L2 (Supplementary Table 14 and Fig. 2K).

Our findings provide mechanistic underpinnings for the previous implication of Del - 1 as a candidate MS susceptibility gene and suggest that Del -1-centered therapeutic approaches may be beneficial in neuroinflammatory and demyelinating disorders.

In addition to finding vaccine candidates, «the most striking feature of N. meningitidis from a genome perspective is that there are more contingency genes than any other bacterium or organism studied so far,» says Hervé Tettelin, leader of the N. meningitidis sequencing project at TIGR.

Picking vaccine candidates from the entire repertoire of genes for an organism «will probably be the only approach used to find vaccines in the future, because the technique is so powerful and so fast,» says Rappuoli.

These findings further underscore the utility of the rabbit hybrid zone for fine - scale mapping of candidate genes likely to be involved in the early stages of reproductive isolation.

Remarkably, 30 regions were each found to contain a single gene, facilitating the identification of candidate genes underlying reproductive isolation.

Such sharing raises the odds that two or more similar patients with candidate genes in common may be found, thereby allowing their condition to be more readily studied and understood.

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