Sentences with phrase «find drug candidates»

The research team will now focus on making changes to the harmine and its relatives (harmalogs) to find drug candidates that target only beta cells.

Not exact matches

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

Key findings presented at AACR included sustained peripheral NK and T cell expansion, doses were well - tolerated and the drug candidate's role as a long - acting CD122 agonist without targeting CD25.

By accelerating promising drug candidates through the drug discovery and development pipeline and spearheading innovative public - private partnerships, we increase the chance of finding an effective treatment, and a cure, for Alzheimer's disease.

Based on their findings, they urge that «mosquito saliva and enhancing antibodies thus need to be considered when developing vaccines and drugs against dengue,» and specifically suggest that «animal models of dengue and pre-clinical validation of dengue vaccine candidates should be evaluated in the combined presence of mosquito saliva and enhancing antibodies.»

It quite simply makes it easier and faster to find candidates for new drugs.

This portion of the pharmaceutical process, in which drug candidates are identified and tested, now employs many of the latest findings in genomics and proteomics.

Dr O'Neill concludes: «Our findings underscore the importance of revisiting unexploited antibiotics as a potential source of new antibiotic drug candidates.

Either way, our findings suggest that CD11b is a key candidate for specific drug development strategies in Guillain - Barré syndrome.»

Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.

However, CiRA researchers from Professor Junya Tochuchda's lab instead looked at molecules related with inflammation, finding Activin - A as a candidate drug target.

«These findings could allow the pharma companies to open up large libraries of potent drug candidates earlier discarded due to solubility problems and try them again together with Upsalite,» says Maria Strømme, Professor at the Division of Nanotechnology and Functional Materials at Uppsala University.

If 40 percent of MSM who are good candidates for PrEP based on CDC's guidelines were actually prescribed the drug and used it consistently, 33 percent of new HIV infections in this population in the U.S. would be avoided over the next 10 years, the researchers found.

The findings, published online today in Scientific Reports, suggest that mifepristone is a promising drug candidate to be repositioned for the treatment of these tumors.

Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

The new blood test will initially be used to identify those people with mild cognitive impairment who are likely to get Alzheimer's disease and so might be good candidates for clinical trials to find drugs that halt disease progression.

The findings of this study suggest a new way to find more effective drug candidates with optimal kinetic and thermodynamic properties.

The work adds to a pipeline of molecular clinical and pre-clinical drug candidates for the treatment of oxidative stress and serves as a good starting point for researchers to find similar compounds, Hannink said.

2002 - 2003 — Vertex finds promising drug candidates among 200,000 compounds tested, including VX - 770 (doorman drug) and VX - 809 (corrector drug).

«When the SSGCID solves protein structures, it lays the foundation for researchers at CID Research and around the world to find new drugs, therapies and vaccine candidates for diseases that kill thousands each year,» said Myler.

The data generated with this model are consistent with clinical findings, and highlight the significant contribution of this Organ - on - Chip technology to recapitulate and even predict the risk for thrombotic events of novel drug candidates.

A follow - up structure - based discovery campaign to develop safer opioids identified PZM21 as both a potential drug candidate and experimental tool to find other safer opioids.

An open - source content management system then would search through upwards of a billion drug combinations to find those with the greatest potential to inhibit a given tumor, or a billion hypothetical compounds to identify candidates for new drug development.

If you're seeking a means of accelerated injury healing and drug - free pain relief or pain management for your best friend, you owe it to both of you to find out whether he's a good candidate for pet laser therapy.

He purchased and delivered a controlled substance to another engineering candidate and the drugs were found in that student's quarters on the base.

[ii] The court found rats are «a good model for determining the effectiveness and potency of a candidate drug in humans» in the area of bone resorption.

Of more than 2,600 hiring managers surveyed by CareerBuilder in 2009, 35 percent had rejected candidates after finding objectionable material, including photos of them using drugs, bad - mouthing previous employers and lying about their qualifications.

The CareerBuilder research revealed that of the 59 percent of hiring managers who used search engines to research candidates, nearly half of them — 49 percent — found information available through social media that impacted the candidate negatively, including provocative or inappropriate photographs, videos, or information (46 percent), information about candidate drinking or using drugs (43 percent), and discriminatory comments related to race, religion and gender (33 percent).