Sentences with phrase «find large number of patients»

Not exact matches

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

The findings of a research group in Manchester, published in the Emergency Medicine Journal, could potentially make a huge difference to a large number of patients.

In the event that it becomes possible to generate large numbers of specialized cells for transplantation, such a facility would aim to find reasonable tissue matches for patients so that rejection can be tackled using conventional immunosuppressives.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

The Krainer team, in collaboration with a team at Isis Pharmaceuticals, surveyed a large number of antisense oligonucleotides (ASOs) and found that some of these ASOs are able to correct the mRNA splicing defect in cultured cells from SMA patients.

Hospitalists typically work in shifts; therefore, within the same hospital, patients treated by hospitalists are plausibly quasi-randomized to a given physician based on when patients become sick and based on hospitalists» work schedule.34 We defined hospitalists using a validated approach: general internists who filed at least 90 % of their total evaluation and management billings in an inpatient setting.35 Second, to evaluate whether our findings were sensitive to how we attributed patients to physicians, we tested the following 2 alternative attribution methods: attributing patients to physicians who had the largest number of evaluation and management claims and attributing patients to physicians who billed the first evaluation and management claim for a given hospitalization.25, 36,37 Third, within some hospitals, male internists may be more likely to work in intensive care units and have severely ill patients.

The findings of this study need to be validated by prospective RCTs with larger patient numbers.

Before the new findings may find their way into treatment, they need to be backed up in a clinical trial with larger numbers of patients and MRI as the endpoint.

A study of individual cognitive therapy for bipolar disorder showed positive outcomes at 1 - year follow - up, but the benefits were reduced over time, suggesting the need for booster sessions to sustain the gains.19 As with many forms of therapy, CBT has been found to be more successful in reducing relapse in the depressive pole compared with the manic pole.30 A large randomised trial of CBT showed no difference between CBT and treatment as usual, when all participants were included in the analyses.31 However, results of a post-hoc analysis suggested that CBT was effective for participants who reported fewer than 12 prior episodes of illness and were not acutely unwell when therapy began; numbers of episodes of mania rather than depression seemed to predict treatment response.32 Such data can help guide the clinical application of CBT for bipolar patients.