Sentences with phrase «find small molecule drug»

«A long - standing dream of cancer biology is to find small molecule drug compounds to restore the activity of p53,» Amaro says.

The good news is that we found a small molecule drug being tested in cancers that activates apoptosis and we decided to test it in combination therapy.»

Not exact matches

These models are amenable to high throughput drug screening and could be used to find promising small molecules to resynchronize or help body clocks function normally.

«Our findings will promote the development of specific small - molecule drugs useful to treat Graves» disease and other dysfunctions of GPHRs.»

The researchers behind the new study, from Winston - Salem State University in the US and Universiti Malaysia Sarawak in Malaysia, have found that adding similar, but smaller polycationic molecules onto a new kind of material called carbon nanodots makes them even better at killing drug - resistant bacteria.

The new method gives scientists more power not only to find new antibody - based therapies, but also to discover the biological pathways through which they work — pathways that may turn out to be more easily and cheaply targeted by small - molecule drugs.

«Together, our findings indicate that these molecular regulators, TRIP - Br2 and GATA3, could be viable targets for small drug molecules that could serve as potential therapeutic agents against obesity,» Liew said.

Many researchers are trying to find ways around this; one possibility is identifying small drug - like molecules that could replace the reprogramming - factor / virus delivery combination.

Scientists can screen collections of small organic molecules — the type of molecules needed for pill - based drugs — to find any that compete with the peptides by binding tightly to Gα proteins and preventing them from transmitting signals.

I wish them well on developing (1) an antibody to detect and image glucosepane in animals (2) a small molecule drug or enzyme (catabody) to remove the glucosepane (3) luck in finding a development partner for this hypothetical glucosepane breaker.

In more current, but not yet published work, Sattler is also fusing NMR and crystallography in a drug discovery project to find small molecule inhibitors that neutralize trypanosoma, parasites that cause sleeping sickness, by disrupting life - critical protein - protein interactions.

«Scientists can now, at the click of a button and at a single online location, rapidly identify the biological and structural characteristics of an actual or potential drug target, find the genes and proteins that it interacts with, assess its structural druggability and identify any small molecule chemical inhibitors.

PTC's GEMS technology exploits the regulatory mechanisms found in the untranslated regions of messenger RNA for the identification of small - molecule drugs that can treat diseases by selectively increasing or decreasing the expression of key proteins by modulating post-transcriptional mechanisms.

«In our previous work, we found that a drug - like small molecule called JQ1 can prevent the development of heart failure in mouse models when administered at the very onset of the disease.