Sentences with phrase «find such tumor»

Once they find such tumor neo-antigens, as they're called, they could design other immunotherapy strategies that could target them.

Not exact matches

According to Organic.org, «Many food colorings contain color additives such as Red No. 3 and Yellow No. 5, which, according to a 1983 study by the FDA, were found to cause tumors (Red No. 3) and hives (Yellow No. 5).»

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»

These findings also have implications for treatment of cancer and other disorders, such as obesity, in which M2 macrophage cells play a regulatory role in tumor growth and fat deposition.

After revealing how these bacteria degraded the drug, he began to wonder if other bacteria might have a similar mechanism for inactivating the drug, and whether such bacteria might be found inside human tumors.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Called the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) and funded by the drug giant Novartis, the trial also found fewer cases of lung cancer in those on the treatment, rekindling basic research findings hinting that the same inflammatory pathway may initiate or spur the growth of such tumors.

More importantly, though, they found about a two-fold higher PD - L1 expression level for gastroesophageal cancers compared to right - side colon cancers but did not find such a marked difference between those tumors and SBAs.

Instead, researchers told the European Breast Cancer Conference that their findings suggest that extending screening programs to older women results in a large proportion of women being over-treated, and at risk from the harmful effects of such treatment, because these women were more likely to die from other causes than from any tumors detected in the early stages of growth.

Other scientists had found evidence that KRAS could drive such tumors.

«We also found that the tumors developed quickly, at the time in early development that corresponds to when such tumors develop in children with the cancer.»

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

If such an indel is found in this gene, Ding and her colleagues suggest a patient may benefit from an EFGR inhibitor, such as erlotinib, regardless of the tumor type.

«It was surprising to find that LECs can play such an active and significant role in tumor spread.»

P: We found discodermolide [a drug from Discodermia, a sponge found in the Caribbean, the Bahamas, and the Gulf of Mexico], and it's gone through phase I clinical trials for treatment of solid tumors such as ovarian, pancreatic, breast, colon, or lung cancers.

The findings made by IMBA scientists now provide evidence that one can find key molecular brakes in innate immune cells that, when modified, allow such cells to seek out and destroy metastatic tumors.

Both Tsigelny and Kurzrock agreed that this finding is an excellent example of the power of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different genes involved in cancer.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

Their findings may turn out to be important when it comes to research into cerebral cancer, since it is known that components of the Hippo signaling pathway, such as neurofibromin 2, are involved in the generation of brain tumors.

Crews noted that RNA splicing - targeted agents have been shown to have activity in a variety of solid tumors so the findings may be relevant to a variety of cancers, such as breast and drug - resistant melanoma.

Tumor necrosis factor inhibitor drugs (commonly called Anti-TNFs) modestly reduce the risk of acute coronary syndrome, such as heart attacks and angina, in rheumatoid arthritis patients whose inflammation places them at higher risk of developing coronary heart disease, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.

The scientists also found consistent evidence of increased pro-inflammatory markers, such as C - reactive protein and tumor necrosis factor alpha, associated with PTSD.

Although MRI can be performed without contrast or enhancing agents, the addition of such agents is often critical for obtaining the detailed images needed for physicians to find the precise location of brain tumors.

Furthermore, the agent prevented the drop in the number of neutrophils (i.e., neutropenia) found in the blood that is typically caused by 5 - fluorouracil, a chemotherapy agent commonly used in the treatment of gastrointestinal and other tumors, such as colon, stomach, pancreas and breast cancers.

The findings, published in Gastroenterology, suggest that circulating pancreas cells (CPCs) seed the bloodstream before tumors can be detected using current clinical tests such as CT and MRI scans.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, known as Stk11, additionally influenced the development of BPH.

Finding cancer early can improve a patient's chances for survival, but small tumors can be difficult to see with scanning techniques such as magnetic resonance...

Additionally, organizations such as Freiburg - based Oncotest, a company founded and directed by Fiebig, and the Jackson Laboratory in Bar Harbor, Maine, provide access to a wide range of PDX mice made from donated tumor tissue.

Tumors are not found in isolation — they are surrounded by a heterogeneous ecosystem of malignant and nonmalignant cells (such as the immune cells that try to keep them in check and the blood cells that nourish them).

The authors undertook a higher - resolution survey of these associations within tumor subtypes, finding known driver events, such as amplifications of MYC, CCND1, ERBB2, and CCNE1 and deletions of PTEN and MDM2, as well as putative but suggestive events involving MDM1, MDM4, CDK3, CDK4, PI4KB, NCOR1, and others.

In cytotoxicity assays employing PPAM, we found no significant differences of IC50 values between SCLC tumor cells, SCLC CTC lines which express the Wnt pathway and normal cells such as HEK293 (data not shown).

After her son developed autism and a benign tumor - Charlie's mother was determined to find out what could cause such seemingly polar diseases.

Further, for each plasmid in the kit, the transcript most commonly found across all TCGA tumor samples is represented, making the results of any such study as clinically relevant as possible.

Many people suffering with cancer and diseases associated with immune dysfunction, such as lymphoma, leukemia, multiple myeloma, solid tumors, recurrent infections, neurodegenerative disorders and other chronic diseases, have turned to the Maharaj Institute in the hope of finding a more favorable prognosis and better quality of life.

The nanoparticles are designed in such a way that this protective layer can only be broken down by a particular enzyme, an enzyme that is found in high concentrations in lung tumors.

Higher serum levels of pro-inflammatory factors such as interleukin - 6 and tumor necrosis factor are found in aged mice.

The finding has far - reaching implications in understanding and treating low - oxygen health conditions such as coronary artery disease and tumor growth.

The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis - related diagnosis (tumor stages, prognosis markers, such as MIB - percentage, hormone receptors, etc.), and therapy - related findings.

They found that decreased presence of lymphatic vessels and reduced immune cytotoxicity were more strongly associated with the metastatic process than tumor - intrinsic factors such as chromosomal instability or cancer - associated mutations.

Our immuno - oncology product candidates are being developed in two separate approaches: one that targets specific antigens and / or epitopes (such as CMB305 and in our neoantigen collaboration); and an alternative approach that leverages the endogenous antigens found in the tumor microenvironment via intratumoral immunization (such as G100).

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

Topics that will be explored include: • Cellular and developmental origins of pediatric cancer • Key findings of pan-cancer analysis efforts • Computational pipelines to analyze large - scale sequencing data • Opportunities for leveraging existing cancer genomics datasets • Strategies for integrative analysis of germline and somatic variants • Correlation of germline / somatic variation to clinical features such as tumor subtype.

Because viruses have evolved such effective methods for finding their target and utilizing the host cells» own molecular machinery, scientists are modifying viruses into long - lasting therapeutic vehicles that can deliver drugs to specific cells or tissues or selectively target and destroy tumors.

For example, proteins related to angiogenesis, the process through which new blood vessels form to ensure supply of oxygen and nutrients to a tissue such as a tumor, are found to be clearly associated to clinical outcome in HPV - positive samples.

No previous technology for capturing CTCs has ever found such clumps of tumor cells.

We know that the lemony aura of limonene is more than just a scent, as it can be found in our blood after exposure.8 Furthermore, several anticancer cellular pathways appear to be affected by the terpene limonene, leading some to suggest it has anticancer, or chemopreventative, benefits.9 While feeding it to rats in studies has revealed some efficacy against breast tumors, 10 we have a ways to go before we can make such bold claims in humans.

And, though they were skeptical that they would observe any difference in tumor biology in the diet - treated patients with such a short - term dietary intervention, just within those few weeks, they found significantly lower cancer proliferation rates, and significantly higher rates of cancer cell death.