The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can
find use in therapies.
Not exact matches
Birds, for example, can regenerate hair cells — and lately researchers have
found a few similar effects
in mammals that
used gene and drug
therapy.
The
findings suggest that the
therapies aren't
used quite like how they're approved by the FDA, which could make a difference
in how the treatments pan out.
It also
uses cognitive behavioral
therapy techniques to help identify the best
therapy for those fighting addiction, assists them
in finding doctors to prescribe anti-opioid medication, and checks
in with them between appointments with addiction counselors.
Editas, a startup based
in Cambridge and
founded in November 2013, wants to eventually
use the technology to treat disease by coming up with
therapies that can modify faulty disease - causing genes.
I came across these developing mainstream medical research programs
using adult stem cell
therapy for MS.. It looks interesting and promising, so I wanted to share
in case you haven't seen it: These were the links I
found:
To be effective and reduce recurrence of cancer
in the prostate, researchers
found that prescribing PARP inhibitors, a drug commonly
used in breast cancer, alongside anti-hormone
therapy treatment may benefit men with prostate cancer.
The
finding is far from definitive evidence of safety, but it's some of the first published animal research supporting the
use of this type of RNA as long - term
therapy in diseases like methylmalonic acidemia (MMA).
In January 2012, a six - year follow - up study of 787 adults who had recently quit smoking found that those who used nicotine replacement therapy in the form of a patch, gum, inhaler or nasal spray had the same long - term relapse rate as those who did not use the product
In January 2012, a six - year follow - up study of 787 adults who had recently quit smoking
found that those who
used nicotine replacement
therapy in the form of a patch, gum, inhaler or nasal spray had the same long - term relapse rate as those who did not use the product
in the form of a patch, gum, inhaler or nasal spray had the same long - term relapse rate as those who did not
use the products.
Dr. Zubair, medical and scientific director of the Cell
Therapy Laboratory at Mayo Clinic
in Florida, says the experiment will be the first one Mayo Clinic has conducted
in space and the first to
use these human stem cells, which are
found in bone marrow.
«We were hoping to
find targets we can
use for
therapy and we were also trying to figure out molecular differences
in different types of epilepsy.
The researchers
found a set of frequently mutated genes
in SBAs that could be helpful to clinicians when they are looking to
use targeted
therapies that work best
in cancers with specifics mutations.
DePuy combed the industry for already approved
therapies with similar properties — and
found a soft - tissue reinforcement patch already
used in hernia repairs made from bovine heart tissue.
Study shows memories formed by the same gene - silencing tool
used in embryonic development; a
finding could set the stage for new
therapies for schizophrenia
The
findings could have implications for the
use of radiation
therapy in the future.
Muotri said the
findings show it is possible to more effectively stratify ASD individuals for clinical trials by identifying persons who are likely to be more responsive to specific
therapies using their «mini-brains»
in a dish.
This
finding led the researchers to assume that
in the future it may be possible for Oxytocin to be
used as a psychobiological treatment option
in couple
therapy as it may increase positive communication behaviors among partners, particularly among couples where the husband suffers from PTSD, and thereby it may improve the quality of the couple's marriage — which is often impaired by the disorder.
«We hope that the
findings of this review will encourage health care providers
in medical settings to seriously consider the
use of music
therapy in the psychosocial care of people with cancer,» Bradt said.
We have
found that exosomes and the cargo they contain are crucial mediators of stem cell - based heart regeneration, and we believe this might lead to an even more refined
therapy using the «active ingredient» instead of the entire stem cell,» said Eduardo Marbán, MD, PhD, director of the Cedars - Sinai Heart Institute and a pioneer
in developing investigational cardiac stem cell treatments.
«
Use of testosterone replacement
therapy in healthy men does not increase risk of heart attack or stroke, new study
finds.»
«
In treating insomnia and other behavioral sleep issues, I have
found that there is no substitute for cognitive behavioral
therapy; yet, it is still unclear how to best
use such
therapy for children with ASD who struggle with communication.»
It will most likely be some time before these new
findings, which are freely available, are put to
use in approved
therapies.
«The
finding from this observational study that women who underwent menopause at a later age and
used oral hormone
therapy had greater hearing loss was unexpected but should lead to more testing
in a randomized, clinical trial,» says Dr. JoAnn Pinkerton, NAMS executive director.
Thus,
finding new targets for drugs already
in use to treat other diseases,
in other words drug repurposing, is an emerging area
in developing anti-cancer
therapies.
And,
in fact, these doctors and researchers are
finding incredible success with this strategy; for example, PD - 1 inhibitors remove this «cloak» that cancers
use to hide from the immune system, and CAR - T cell
therapies use specially engineered T - cells to seek cancer - specific proteins and destroy the cancer cells to which they are attached.
It
uses a virus already approved by the Food & Drug Administration for other genetic
therapies in the eye; it delivers an ion channel gene similar to one normally
found in humans, unlike others that employ genes from other species; and it can easily be reversed or adjusted by supplying new chemical photoswitches.
In a 2001 study sociologist Ronald C. Kessler of Harvard Medical School and his associates
found that more than half of people with panic attacks or severe depression
used some form of alternative
therapy, including herbs, during the previous year, usually without medical supervision.
Then they expose these mutated yeast cells to a whole range of chemical compounds
used in cancer
therapy to
find which ones will kill them.
The study, published
in the Journal of Gambling Studies,
found that the effectiveness ofGambers Anonymous needs to be studied further, but appeared to show better rates of abstinence, improved gambling symptoms and better quality of life, especially when
used in conjunction with other approaches, such as stress management intervention and cognitive behavioural
therapy.
The
findings, published online August 17
in Tobacco Control, suggest that the primary effect of varenicline (marketed as Chantix) has been to displace the
use of older tobacco addiction
therapies, such as nicotine patches and the antidepressant, bupropion (Zyban).
While there was some loss
in newly formed spongy bone, the researchers
found that this could be remedied by
using the sclerostin antibody
in combination with other
therapies.
Researchers
found the gene
therapy approach had stronger results when
used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.
The
findings suggest it may be possible to reduce the rate of HIV infection among babies
in poor countries with an inexpensive version of the more elaborate AZT
therapy currently
used in the United States and Europe.
Their
findings could help to improve breast cancer prevention by targeting these specific biological mechanisms with cancer
therapies in at risk patients and potentially lead the way for a new strategy for the
use of preventative treatments.
The research team
found that when a particular mitochondrial fission protein (GTPase dynamin - related protein - 1 — Drp1) was blocked
using either gene -
therapy or a chemical approach
in experimental models of PD
in mice, it reduced both cell death and the deficits
in dopamine release — effectively reversing the PD process.
It might be possible,
in future, to
use biomarkers to define patient subgroups and treat them with customised cancer
therapy or to
find new treatment options as an alternative to surgery.
In addition to determining that humans use chemosignals to attract one another, the findings could one day be used to create new therapies to correct hormone imbalances — most notably alternatives to cortisol replacement, which is used in treat maladies such as Addison's disease (in which the adrenal glands fail to pump out enough cortisol, causing muscle weakness, weight loss and low blood pressure
In addition to determining that humans
use chemosignals to attract one another, the
findings could one day be
used to create new
therapies to correct hormone imbalances — most notably alternatives to cortisol replacement, which is
used in treat maladies such as Addison's disease (in which the adrenal glands fail to pump out enough cortisol, causing muscle weakness, weight loss and low blood pressure
in treat maladies such as Addison's disease (
in which the adrenal glands fail to pump out enough cortisol, causing muscle weakness, weight loss and low blood pressure
in which the adrenal glands fail to pump out enough cortisol, causing muscle weakness, weight loss and low blood pressure).
Women who
use postmenopausal hormone replacement
therapy (HRT) may be at increased risk of acute pancreatitis,
found a new study
in CMAJ (Canadian Medical Association Journal).
While the researchers can not yet point to a potential therapeutic application of their
findings, identifying genetic changes that underlie MND is the first step
in finding ways to manipulate these changes
using gene
therapy.
With these
findings, Helmholtz Zentrum München scientists have discovered key molecular functions of stem cell differentiation which could be
used for beta cell replacement
therapy in diabetes.
They
found studies
using gene
therapy to promote the growth of «almost every different tissue» for
use in regenerative surgery.
The
finding suggests that the drug — methylnaltrexone, approved for
use by the United States Food and Drug Administration
in 2008 to treat opioid - induced constipation — could play a role
in cancer
therapy.
Now, researchers have
found a clever way of
using these implants to deliver new genes right into the ear — a
therapy that,
in guinea pigs, dramatically improves hearing.
«These
findings suggest that BES may thus be
used as a strategy to improve cell survival and prevent cell apoptosis
in stem cell - based transplantation
therapies,» Fan explained.
Using patient tissues obtained directly from operating rooms, the researchers
found that the cells began to adapt to and resist
therapies that target the growth pathway called mTOR
in as little as 48 hours.
We will need to carry out further studies with larger sample sizes to confirm the current
findings, but we hope that,
used in conjunction with medication and current psychological
therapies, this could help people with schizophrenia minimise the impact of their illness on everyday life.»
These
findings, which will be published online Aug. 18
in Proceedings of the National Academy of Sciences, could help identify important brain circuits involved
in stroke recovery and usher
in new clinical
therapies for stroke, including the placement of electrical brain - stimulating devices similar to those
used for treating Parkinson's disease, chronic pain and epilepsy.
Researchers at Norris Cotton Cancer Center have
found an antibody that may be
used in future treatments for recurrent small - cell lung cancer, which currently has no effective
therapy.
In laboratory tests
using rodents, White and his colleagues
found that while morphine lost its pain - relieving effectiveness three weeks after nerve injury, a combination
therapy of morphine and carbamazepine —
used to prevent epileptic seizures — could effectively reverse this loss of drug action.
John Rossi, a molecular geneticist at the City of Hope
in Duarte, California, says the
findings open the door for
using microRNA - based
therapies in people.