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Finding genes for complex traits: mostly agony and little ecstasy,» presented by Dr. Rory Todhunter, BVSc, PhD, Greenberg Professor of Surgery, Cornell University Department of Clinical Sciences
As soon as the near completion of the human genome was announced, commentators played up the payoff of
finding genes for all sorts of diseases.
In discussing why genetics researchers are not
finding genes for disease susceptibility, the «dark matter» of genetics, Peter Aldhous and...
They found genes for five new receptors, all of which belong to a known family of proteins called formyl peptide receptors (FPRs).
Moreover, within Mimi's outsize helping of genetic material, Claverie
found genes for such things as the translation of proteins, DNA repair enzymes, and other types of protein.
The researchers also identified genes responsible for important traits such as disease resistance, wood formation, and stress response; they did not, however,
find any genes for ruining presidential golf games.
She found a gene for what's known as the major histocompatibility complex (MHC)-- cell surface molecules that help the immune system recognize foreigners — that was remarkably similar to one in humans that allows infected people to keep the virus in check for decades.
«If you can
find a gene for blond hair that exists in Melanesia and nowhere else,» Myles says, «then there's no reason why those sorts of genes don't exist all over world in underrepresented populations, and affect not only hair pigmentation, but also disease - related traits.»
They have also compared the mouse and human genomes, which together are expected to help researchers
find genes for diseases and lead to new treatments for human illness.
Umarova, A., Garcia, A., and Linder C.
Finding the gene for repro29 infertile mice: Zcchc8 candidate gene sequencing.
They don't want parents to think scientists have
found the gene for ADHD.
This study is to
find the gene for PCD and subsequently develop a DNA - based test for the disease.
Only when
we find the gene for one form of cataract, will we know about the others.
1 Why do we find it so hard to get (and stay) organized?Many people think organization is an inherited trait; however no DNA study has ever
found a gene for being organized!
Not exact matches
Birds,
for example, can regenerate hair cells — and lately researchers have
found a few similar effects in mammals that used
gene and drug therapy.
At last year's Brainstorm Health conference in San Diego, Bergh
found himself sitting at dinner with Othman Laraki, the cofounder and CEO of Color Genomics — a company that extracts the DNA from a customer's submitted saliva sample and then looks
for a set number of
gene mutations known to be associated with increased risk
for developing certain hereditary cancers or heart conditions (depending on the test).
Editas,
founded in 2013 in Cambridge, Massachusetts, is a visionary
gene - therapy company with a pipeline of therapies
for cancer and lung, liver, muscle, eye, and blood diseases.
By contrast, genetically modified organisms are ones where scientists have taken a
gene for a specific trait that would not be
found in that species normally, and spliced it into the genome.
The test has genetic counselors and scientists concerned, because there are thousands of mutations associated with the BRCA1 and BRCA2
genes and this test screens
for only three of them most commonly
found in people of Ashkenazi (Eastern European) Jewish descent.
Paradoxically the more atheists I come into contact with the more strength I
find in my belief that they,
for lack of a better term, lack a certain
gene (yes, I get the irony).
*** The search
for a «gay
gene» may be off - target, new research
finds.
It appears that the
gene for cystic fibrosis is
found in a narrow region on chromosome seven.
[The search
for a «gay
gene» may be off - target, new research
finds.
Richard Dawkins, in his celebrated book, The Selfish
Gene, exemplifies the same position.3 And a similar reduction of biology to a molecular science may be
found in the writings of E.O. Wilson, Ernst Mayr, Jacques Monod and numerous other highly respected scientific writers.4 In Chance and Necessity,
for example, Monod gives one of the most forceful renditions of the view that biochemical analysis is «obviously» the sole avenue to understanding the secret of life.5 Decades ago Jacques Loeb had already set forth the program of inquiry still emulated today by many biologists:
When considering the
founding kind pairs, we are looking at most to 4 alleles
for each
gene (1 / chromosome, 2 chromosomes / ndividual, 2 individuals).
Go on, deny that it happened or
find some way to pin the blame on my parents
for moving to Britain or me
for polluting the
gene pool by marrying an Englishman.»
And yes, it is a chosen lifestyle,
for those gay doctors / scientists who are attempted to try to discover a gay
gene, and make God out to be a liar, they have
found no such
gene!.»
On the contrary, he
finds it useful to ponder an array of reductionist attempts to explain the existence of religion, from that which seeks to pinpoint the area of the human brain or the specific
genes connected to religiosity to that which sees religion as a malfunction of the human mind or a vestigial remnant from a primitive stage of human development suitable only
for whimpering, immature dullards (a point of view championed by the new atheists).
A World War II veteran who lived through the invasion of Normandy on D - day,
Gene returned home to Petaluma, CA to
found what is now one of the most respected dairy processors in the country, and became a pillar of his community, known
for his generosity to those less fortunate.
«Ninety five percent of the aromatic rice analyzed shared the same version of the major
gene for fragrance
found in Thai Jasmine rice,» says Dr. Melissa Fitzgerald, grain quality researcher at IRRI.
Los Baños, Philippines — The version of the
gene primarily responsible
for the aroma in Thai Jasmine rice is
found...
I'm heading to Portland, OR,
for a friend's wedding, so I'll be eating plenty, including at visits to Ava
Gene's and Maurice, where I'm hoping to
find something that channels a crunchy carrot slaw and this Maurice bostock, a sweet, bready revelation.
For those who have MTHFR
gene variants, supplemental folic acid has not been
found to reduce the risk of miscarriage.
Both kids have had their work selected
for the town art show and I am glad the art
gene has
found a way to my family.
Similar mechanisms are
found in human brains — caregiver behavior matters
for turning
genes on and off.
The U.S. Department of Agriculture has given a provisional go - ahead
for genetically modified rice containing human
genes to be grown in Kansas, despite concerns that the proteins from the pharma rice could
find their way into the food chain.
UT Southwestern biochemists studying mouse models
found that the two proteins − steroid receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control
genes for pulmonary surfactant components that promote the initiation of labor.
A New York patient is now the second U.S. citizen to be infected with bacteria carrying a «superbug»
gene, according to
findings published earlier this week in the journal
for Antimicrobial Agents and Chemotherapy.
The researchers then
found that these same
genes carry an additional risk
for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region in the brain.
The field of cancer epigenetics was recently transformed by the
finding that
genes encoding
for epigenetic regulators are among the most commonly mutated
genes in human cancers.
«But the discovery of this network of
genes linked to epilepsy opens avenues
for finding new treatments.
He added that the method used in this study, called «network biology» — where computer systems are used to identify
gene networks that work together to underpin disease — may also help
find treatments
for other conditions.
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for affordable
gene enhancement procedures can now be
found across the Web, promising to «alter muscle
genes» or «trigger your genetic muscle - building material.»
So Beller's team looked
for just such a cluster of
genes among the candidate
genes in the toluenemaking sewage sample, and they
found the GRE phenylacetate decarboxylase (PhdB) and its activator, PhdA.
When similar analysis was performed on the db mice, it was
found that the disrupted db
gene was responsible
for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.
This
finding came as a surprise since it was assumed that as a consequence of the evolutionary divergence between human and other animal viruses, the
genes that code
for LANA could not be switched.
To
find out, the biologists developed a way to incorporate the
gene for the human L - type photopigment into a small virus known as adeno - associated virus.
Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute
for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to
find that genetic markers in the
gene responsible
for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.
As well as understanding the implications of
finding this new variant of the botulism
gene cluster in a non-clostridial species of gut bacterium, the team are interested in exploring how it might help in developing new treatments
for diseases.
Before Krieger started tinkering with the mouse
gene SCARB1, he had identified SRB1, a protein
found on the surface of the liver cells, as that dock
for HDL.