John McDowell of Virginia Tech worte an invited Commentary in the prestigious journal, Proceedings of the National Academy of Sciences, comparing
findings about the genomes of plant pathogens.
Not exact matches
[1:20] How the kindness of a stranger changed Tony's life [3:35] Peter Diamandis talks
about the origins of X Prize [6:30] Technology helping the agricultural industry [7:00] Sequencing
genomes [8:55] Life - work integration [11:15]
Finding your highest calling in life [12:00] Reframing what is «impossible» [14:00] Strategy vs. psychology [15:00] Changing your state [16:00] The science of achievement, the art of fulfillment [19:00] Living in a beautiful state [24:00] Thinking 10x bigger [28:00] Surrounding yourself with a «nothing is impossible» community [29:00] The news pollutes your mind [31:00] Tony's natural gifts and core beliefs [33:30] Overcoming failure and criticism [37:45] Defining your environment [40:00] Life happens for you, not to you [42:00] Rituals and practices to up your game [46:30] Tony's priming process
A human - chimp comparison revealed some 35 million mutations in the single units of the overall sequence and also
found about 5 million additions to or subtractions from the
genome involving chunks of DNA sequence.
I
found this article
about these guys at the Tel Aviv University that made the
genome of the model of wheat, the same grain I used and just made a light bulb light up and I just contacted them and within a few days I had several kilograms of this material, we just started to process and eventually is this beer that we're drinking.
Science writer Mitch Leslie talks to postdoc Liz Cirulli
about her work on a study that takes a whole -
genome approach to
finding clues to longevity among centenarians.
As such, the
genome holds much less influence
about longevity than expected and our results help to explain why [
genome studies] of longevity have failed to
find a reliable signal so far,» noted Erlich.
To
find out more
about how they manage to survive, Brandon Briggs at Miami University in Oxford, Ohio, and Frederick Colwell at Oregon State University in Corvallis have sequenced and compared
genomes belonging to one particular class of deep life — Firmicutes bacteria — sampled 21, 40 and 554 metres below the floor of the Andaman Sea, west of Thailand.
The researchers also asked nine factual questions
about genome editing and
found sharp differences in support for both treatment and enhancement based on knowledge.
Earlier surveys of Americans (here and here) have
found a reluctance to support human
genome editing, with many respondents expressing ethical and other concerns
about such intentional tinkering.
This timeline highlights key discoveries
about our closest relatives, from early fossil
finds to the publication of the draft nuclear
genome sequence.
Today's report includes the first recommendations ever given to labs and doctors
about how to handle unexpected
findings when the
genome or its protein - coding «exome» is sequenced.
What is known
about Azolla's true inner workings may still only skim the surface, but people all over the world, like Kathleen Pryer, a Duke professor who is crowdfunding the fern's
genome, have continued to
find creative ways to explore its possibilities.
The sequenced
genome of a single individual yields
about half a terabyte of data of information — that's
about as much information as you'll
find on 106 DVDs.
The team
found that such occurrences in the
genome are not uncommon;
about 50 percent of the analyzed gRNAs had the potential to be affected by variants at their target sites.
Through more than 1,600 separate experiments, analysis of more than 140 cell types and a massive amount of data analysis, the group
found about 4 million of these so - called switches and can now assign functions to more than 80 percent of the entire
genome.
All together, the researchers
found about 37,000 mutations occurring in 10,000 clusters in the chimp and human
genomes that they think were caused by these proteins, they report today in
Genome Research.
The
genome shares
about 60 % of its genes with the other invertebrates completely sequenced, such as the nematode and fruit fly, whereas
about 5 % match sequences
found only — up to now, at least — in the human, mouse, and puffer fish
genomes.
After comparing all three
genomes, the researchers have now
found that tardigrades borrowed only 133 genes,
about 0.7 percent of their genes, from other organisms.
The human
genome — the sum total of hereditary information in a person — contains a lot more than the protein - coding genes teenagers learn
about in school, a massive international project has
found.
«Our
findings underscore the need for increased awareness and education
about prevention and early detection and treatment of CVD in African American women and younger adults of low socioeconomic status,» said Samson Y. Gebreab, Ph.D., M.Sc., lead study author and research scientist at the National Human
Genome Research Institute, Bethesda, Maryland.
There are
about 10 million of them in the human
genome (often
found in the DNA between genes), and most have no effect on health or development.
When the Max Planck scientists compared the bonobo
genome directly with that of chimps and humans, however, they
found that a small bit of our DNA,
about 1.6 %, is shared with only the bonobo, but not chimpanzees.
Previous claims of fossil DNA
finds have not been verified; the oldest DNA yet recovered comes from Neanderthals up to
about 50,000 years old (see Neanderthals have
genome chunk sequenced).
Two groups of researchers published the first
genome - wide CNV maps, which illustrated that variation in gene quantity is actually quite common: each group
found about 12 copy number imbalances per person.
A second major
finding of the new study, which analyzes the
genomes of over 2,500 «simplex» families — those in which a single child but neither parent nor siblings, if any, have ASD — is that the pool of spontaneously mutated genes contributing to ASD across the population totals
about 400.
Analyzing the
genomes of more enslaved Africans «and [
finding] out where they came from... can tell us more
about these people's identities and how they transformed over the centuries that followed,» he says.
The team says the new
genome confirms their previous
findings, showing that
about 3 % of the
genomes of living people in Papua New Guinea come from Denisovans, while the Han and Dai on mainland China have only a trace of Denisovan DNA.
But that DNA is in relatively long, unbroken chunks, the analyses
found, suggesting that it was incorporated into Polynesians»
genomes recently, perhaps
about 500 to 2500 years ago, after the Lapita period.
The genetic data, which includes
about one million markers across the
genome, is compared among individuals, among populations, and between current and ancestral populations to determine hidden patterns of relatedness, sort individuals into groups that share genetic characteristics, and
find correlations with genes of medical relevance.
As it turns out, the same mutations could have been
found by sequencing only the protein - coding regions of the
genome — called exome sequencing — for
about $ 4000.
They
found that 1285 loss - of - function gene variants are likely genuine,
about 100 of which appear in the
genome of the average European, MacArthur's team reports today in the 17 February issue of Science.
To
find rarer SNPs that occur at 1 % frequency,
genome leaders say, they need to sequence
about 1000
genomes.
«They've actually been able to dig down into the
genome and
find out a little bit more
about [parallel evolution],» says Tim Coulson, a population biologist at the University of Oxford in the United Kingdom.
They were then able to sequence a large portion of the golden - crowned manakin's
genome including 16,000 different genetic markers,
finding that
about 20 per cent of its
genome came from the snowy - crowned, and
about 80 per cent came from the opal - crowned.
We provide initial insights into two critical issues: what clinical value can be extracted from different commercial and academic cancer genomic platforms, and how to think
about scaling access to that value,» noted the study's Principal Investigator, Robert Darnell, MD, PhD, Robert and Harriet Heilbrunn Professor and Senior Attending Physician at The Rockefeller University and
Founding Director of the New York
Genome Center.
The Rush team brought the samples to U-M's Center for Microbial Systems for sequencing, and Snitkin's team started to put the
genome data together with what Hayden's team had
found out
about the outbreak.
Hakonarson's team conducted a
genome - wide scan of
about 1,000 pediatric diabetes patients, 1,200 healthy children and 1,000 parents of diabetics to track down any links between the illness and 550,000 known mutations
found in their genetic code.
If you want more great stories
about the cat
genome and domestication, you'll
find good articles in Wired Magazine and the Washington Post.
More details
about The Cancer
Genome Atlas, including Quick Facts, Q&A, graphics, glossary, a brief guide to genomics and a media library of available images can be
found at http://cancergenome.nih.gov. Reference: The Cancer
Genome Atlas Research Network.
And now some of those superfans from the National Cancer Centre Singapore (NCCS) and Duke - NUS Medical School (along with some financial donors who just love durians enough to privately fund a study
about them) have completely mapped the durian
genome to
find out, among other things, why the putrid stench, durians?
This briefing enabled journalists to
find out
about molecular genetic techniques for
genome editingand tools for epigenetic modification.
Applying high - throughput sequencing technologies to obtain sequences from most of the
genome, we calculated that the passenger pigeon's effective population size throughout the last million years was persistently
about 1/10, 000 of the 1800's estimated number of individuals, a ratio 1,000 - times lower than typically
found.
About the Broad Institute of MIT and Harvard The Eli and Edythe L. Broad Institute of MIT and Harvard was
founded in 2003 to empower this generation of creative scientists to transform medicine with new
genome - based knowledge.
Last week ENCODE published their
findings in 30 papers, representing a significant advance in understanding
about the function of the human
genome.
Whole
genome and whole transcriptome sequencing of 31 pediatric Asian patients with T - cell acute lymphoblastic leukemia
found that
about 10 percent had the same alteration in a non-coding region of DNA.
Information
about the Personal
Genome Project, recently published in the CMAJ can be
found here:
But I was most excited
about a different use of the data, and I
found myself counting the months until the
genome of a chimpanzee would be sequenced.
yourgenome is the place for you to
find out everything you want to know
about DNA, genes and
genomes.
For the First Time, Recommendations Offer Guidance
about Incidental
Findings in Clinical Genomic Sequencing: Brigham and Women's Hospital, March 21, 2013: In a highly anticipated report, landmark recommendations on the handling of incidental findings in clinical genome and exome... Continue r
Findings in Clinical Genomic Sequencing: Brigham and Women's Hospital, March 21, 2013: In a highly anticipated report, landmark recommendations on the handling of incidental
findings in clinical genome and exome... Continue r
findings in clinical
genome and exome... Continue reading →
Whole
Genome Sequencing Not Informative for All A study involving data of thousands of identical twins by Johns Hopkins investigators finds that whole genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test re
Genome Sequencing Not Informative for All A study involving data of thousands of identical twins by Johns Hopkins investigators
finds that whole
genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test re
genome sequencing fails to provide informative guidance to most people
about their risk for most common diseases, and warns against complacency born of negative
genome test re
genome test results.