Sentences with phrase «findings in subsets of patients»

The study was not powered to detect this improvement, but Kelbaek said he and his team would now look carefully for possible «hypothesis - generating» findings in subsets of patients — both those who might have benefitted from the deferred - treatment strategy and, equally important, those in whom this strategy might have worsened their condition.

Not exact matches

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

After a median follow - up of 22 months, the team found that the drugs were safe and shrank tumors in a subset of patients, with an overall response rate of 27 percent, which included complete responses in two patients and partial responses in four patients.

In a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subseIn a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subsein each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subsein the HR positive subset but not in the HR negative subsein the HR negative subset.

Although it is among the most highly metastatic of all cancers, multiple myeloma is driven to spread by only a subset of the myeloma cells within a patient's body, researchers at Dana - Farber Cancer Institute have found in a study presented at the annual meeting of the American Society of Hematology (ASH).

«We found that intensive doses of statins carry the potential for clearing up the lipid debris that can lead to vision impairment in a subset of patients with macular degeneration,» said Joan W. Miller, M.D., the Henry Willard Williams Professor and Chair of Ophthalmology at Harvard Medical School and Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital.

But that optimism, plus the availability of FDA - approved drugs with an HDAC inhibitory effect, has also prompted many families to find doctors who will prescribe these drugs, without knowing whether they work, or at what doses, or in which subset of patients.

[44] Two other phase II clinical trials evaluated the efficacy of imatinib in patients with melanoma — including mucosal melanomas — harboring KIT mutations and / or amplifications, with a subset of cases involving mucosal primaries, and both found a disease control rate of approximately 50 %.

The physical findings in persons meeting the Canadian definition may signal the presence of a neurologic condition considered exclusionary for CFS and thus the XMRV positive persons in the Lombardi et al. study may represent a clinical subset of patients [11].

MYH7 mutations were predominantly found in Ebstein anomaly associated with LVNC and may warrant genetic testing and family evaluation in this subset of patients.

This is an exciting finding as it suggests that the immune responses activated in at least this subset of PD patients resemble those driving autoimmune diseases like multiple sclerosis.

Struggling to find more in - depth answers, Loggia noted that American and German researchers have recently identified a subset of fibromyalgia patients who appear to have abnormalities in some of their peripheral small nerve fibers.

Possibly, mania is a more purely biologically driven phenomenon than bipolar depression, with onsets more readily attributable to medication inconsistency, sleep deprivation, circadian disruption, or behavioral activation.21,22,84 - 86 In contrast, social and familial support has been found to protect against depression in bipolar and unipolar affective disorders, but the role of these variables in manic recurrences is unclear.86 - 88 An analysis of laboratory interactional data from a subset of 44 families in this sample revealed that treatment - related improvements in family communication skills were more closely associated with reductions in patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factorIn contrast, social and familial support has been found to protect against depression in bipolar and unipolar affective disorders, but the role of these variables in manic recurrences is unclear.86 - 88 An analysis of laboratory interactional data from a subset of 44 families in this sample revealed that treatment - related improvements in family communication skills were more closely associated with reductions in patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factorin bipolar and unipolar affective disorders, but the role of these variables in manic recurrences is unclear.86 - 88 An analysis of laboratory interactional data from a subset of 44 families in this sample revealed that treatment - related improvements in family communication skills were more closely associated with reductions in patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factorin manic recurrences is unclear.86 - 88 An analysis of laboratory interactional data from a subset of 44 families in this sample revealed that treatment - related improvements in family communication skills were more closely associated with reductions in patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factorin this sample revealed that treatment - related improvements in family communication skills were more closely associated with reductions in patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factorin family communication skills were more closely associated with reductions in patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factorin patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by different constellations of risk and protective factors.