Sentences with phrase «first angiogenesis»

A: My project was to isolate the first angiogenesis inhibitors.

Not exact matches

Trebananib (formally known as AMG 386; Amgen) is a first - in - class peptide - Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumors) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor.

«What's more, the cancer - related proteins were using first neighbours to interact with the pathways controlling important processes for carcinogenesis, such as angiogenesis, autophagy and DNA repair.

It was the first drug designed to inhibit new vessel growth (angiogenesis), and was approved by the FDA in 2004 for treating colorectal cancers — which typically boost angiogenesis to keep themselves well supplied with oxygen and nutrients.

«Our study provides the first evidence that endothelial CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation,» says Dr. Yan.

They first induced angiogenesis in mice through the injection of a growth factor called FGF - 2 and measured blood vessel development in the presence and absence of synthesised IP5.

This is the first evidence that starvation of endothelial cells could offer new therapeutic opportunities for the treatment of excessive angiogenesis in diseases (like cancer).

The immortalized endothelial cell lines established from H - 2Kb - tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems.

Whether testing behaviour with vision - related tests, vascular pressure, metabolic disorders, or angiogenesis, an examination of the retina can be a critical first line test.

At first glance, a puzzle emerges: why would a cancer â $ œwantâ $ to induce blood clots? Cancer cells often send out growth factors that stimulate the growth of new blood vessels (angiogenesis).

In the past 10 years our laboratory has investigated the role of cell - matrix interaction in the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesis.

In this scenario, pericyte Tie2 deletion leads to a transient delay first, of angiogenesis (P4) and second, of vessel maturation (P6).

In 2001, she co-organized Columbia University's first Arden House symposium on angiogenesis.

We show for the first time that kahweol is an anti-angiogenic compound with inhibitory effects in two in vivo and one ex vivo angiogenesis models, with effects on specific steps of the angiogenic process: endothelial cell proliferation, migration, invasion and tube formation on Matrigel.

His vast basic knowledge of angiogenesis, combined with his first - hand experience in clinical medicine, led to numerous breakthroughs in the field of vascular biology and provided the groundwork, and the inspiration, for other laboratories to contribute to this field.

His laboratory was the first to purify angiogenesis regulators, develop all of the assays required to study this process and propose the concept of angiogenesis - dependent diseases.