Sentences with phrase «first animal models»

This study provides one of the first animal models to demonstrate the long - term cognitive deficits resulting from a chemotherapeutic treatment used in treating humans for breast cancer.

«This is the first animal model to link pathological shifts in endogenous bacteria with the inhibition of regeneration,» says Alejandro Sánchez Alvarado, Ph.D., an investigator at the Stowers Institute and the Howard Hughes Medical Institute, and senior author of the study.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

«The first animal model for sexual transmission of HIV.»

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves» disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

«This is exciting because it's the first animal model of pediatric high - grade gliomas, or malignant brain tumors,» says Maria Castro, Ph.D., senior author of the paper and a professor in the departments of Neurosurgery and Cell and Developmental Biology at U-M.

Not exact matches

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

«Cerebellar interactions with the frontal cortex in cognitive processes has never been shown before in animal models,» says Parker, UI assistant professor of psychiatry and the first faculty hire of the new Iowa Neuroscience Institute.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Hackett said, «Studies of human immunology are usually not the first choice for research in basic immunology, but it is very important now to understand how humans differ from animal models.»

Mao was among the first to delve into potential mechanisms of OIH in an animal model.

In an animal model, they demonstrated for the first time that two proteins designed by the researchers not only recover muscle force and increase body weight in the sick animals but also significantly prolong survival.

Two of them also prove for the first time in an animal model that Zika virus can cause microcephaly in fetuses.

They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a measure of spatial memory which is impaired in other animal models of concussion and human patients.

The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.

Hope Mirendil, an alumna of the TSRI graduate program and first author of the new study, spearheaded the effort to develop the first - ever animal model of fetal cerebral hemorrhage.

«We have demonstrated for the first time in an animal model that maternal use of a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs, resulted in increased fat accumulation and inflammation in the liver of the adult offspring, raising new concerns about the long - term metabolic complications in children born to women who take SSRI antidepressants during pregnancy,» says PhD student Nicole De Long, who presented this research on June 22nd at the joint meeting of the International Society of Endocrinology and The Endocrine Society.

The ongoing Zika virus outbreak in Latin America and the Caribbean has created an urgent need for identifying small animal models as a first step toward developing vaccines and treatments to fight the infection.

«Usually, when researchers want a mouse or other animal model to express fluorescent proteins in certain cells, they need to develop genetically modified animals that can take months to years to make and characterize,» says former graduate student and first author Ken Chan (PhD» 17).

Scientists have developed the first true animal model of Huntington's disease, a progressive and often fatal deterioration of the central nervous system.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopaFirst, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopafirst such animal model of the disease — and exposed them to ziram so that they lost dopamine.

«For the first time, we can provide a complete description of an animal model from genes to behavior — including at the level of neuronal network activity, which has been ignored in most studies to date.»

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

«This is the first example of taking a genetic sequence and designing a drug candidate that works effectively in an animal model against triple negative breast cancer,» said TSRI Professor Matthew Disney.

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast cancer.

The first genetic clues for slowing aging emerged from animal models in which the effect of individual genes on average life spans could be tested.

The faster speed means it will be possible for the first time to watch disease progression in living animal models at the molecular level.

As a first step, they have created a novel animal model that replicates the response of human skin to severe burns, skin grafts and laser therapy.

The study, performed in an animal model, was the first to identify growth differentiation factor 10, or GDF10, a molecule that previously had no known role in the adult brain, said Dr. S. Thomas Carmichael, the study's senior author and a professor and vice chair for research and programs in the UCLA department of neurology.

Scientists at the Technical University of Munich (TUM) have now shown for the first time in an animal model that they enhance and temporarily store sensory information.

It is also the first to demonstrate that a deep convolutional neural network — a computing system modelled after the neuron activity in animal brains that can basically learn on its own — can effectively differentiate between similar plants with an amazing accuracy of nearly 100 %.

Egri's team picked up on a theory first proposed in 1930 and backed up in 1981, when it was demonstrated that biting tsetse flies were least attracted to striped animal models, when compared to black or white models.

This knowledge opens up possibilities about treatment ideas that can be tested in animal models as a first step toward human trials.

«When we first tested dietary supplements in animal models we found that the results were promising,» says Byers.

«This is the first study to demonstrate that functional muscle cells can be created in a laboratory and restore dystrophin in animal models of Duchenne using the human development process as a guide.»

In their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal model.

«The results of the study are truly promising, since we were able to show for the first time that A2A adenosine receptor antagonists actually have very positive effects in an animal model simulating hallmark characteristics and progression of the disease.

To test the effects of such exposure, the researchers must first create an animal model.

«Our next step is to test Alphamers in animal models of infection with multidrug - resistant bacteria that pose a public health threat, such as MRSA,» said first author Sascha Kristian, PhD, visiting research scholar at UC San Diego and associate research director at Altermune Technologies, a company Mullis founded to develop Alphamers into unique therapeutics.

For the first time, an animal model can express the two biological characteristics of Alzheimer's disease.

«This is the first study in a rigorously controlled animal model to find that CBD appears to protect the brain against the negative effects of chronic THC,» Mackie said.

The French Foundation for rare diseases (Fondation des maladies rares), in partnership with TEFOR infrastructure, launches its first call for research projects «Small animal models and rare diseases».

I think only the future will be able to show whether we can use these strategies really to improve clinical deficits first in animal models, and then later on, of course, also in clinical trials.

We're extremely excited — it's the first - ever human HD trial to fight HD at the root of the problem, and has shown great promise in animal models.

The model is the first to focus on how and why home ranges expand or contract in territorial animals, a trend noted in multiple animals ranging from deer and pandas to owls and flying lizards.

The finding, the first discovery of a so - called «master» gene for myocardial, or heart muscle, cells in an animal model, puts researchers on track for exploring the capability of homologous genes in mice and humans.

We have created the first such animal model through the expression of C3, and it recreates many of the features of dry as well as wet AMD.

The finding represents the first demonstration in an animal model, Stainier said, that endothelial cells are necessary for the proper differentiation of red blood cells.

Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.

In laboratory experiments, first in animal models and then in greater detail in the petri dish, the researchers tracked Arc's movements.