20 We are family: Scientists suspect that a large DNA - based virus took up residence inside a bacterial cell more than a billion years ago to create
the first cell nucleus.
Not exact matches
First, an adult
cell would be removed from a patient and the DNA of that
cell altered to control and direct the types of gene expression the
nucleus is capable of supporting.
And when the
first cell formed, how did the molecules randomly form all of the different parts of the
cell like the
nucleus and everything else?
Biochemist Radhey Gupta of McMaster University in Canada proposes that a bacterium and an archaean fused to form the
first eukaryote, based on his analysis of a pair of slow - changing genes found in what may be one of the oldest
cells with a
nucleus, Giardia lamblia.
The larger organelles, such as the
nucleus and vacuoles, are easily visible with moderate magnification (although sometimes a clear view requires the application of chemicals that selectively stain parts of the
cells); they were among the
first biological discoveries made after the invention of the microscope.
The latest such roster — 271 proteins identified in a compartment of the
cell nucleus called the nucleolus — is a
first step toward fully deciphering this organelle, a critical element in the construction of ribosomes, which build proteins.
To tally the proteins, the largest ever reported for a single organelle,
cell biologists Angus Lamond of Scotland's University of Dundee, Matthias Mann of the University of Southern Denmark in Odense, and their colleagues
first separated the nucleolus from its gelatinous home in the
nucleus.
This is the
first eukaryote — organisms, like plants and animals, whose
cells contain distinct
nuclei — found without the machinery of mitochondria.
In 1957, developmental biologists
first discovered that they could insert the
nucleus of adult frog
cells into frog eggs and create dozens of genetically identical tadpoles.
It is the
first synthetic chromosome ever assembled from a eukaryotic organism, the type in which
cells store DNA in
nuclei.
Previous research by Burger and Stefan Oline — a former Ph.D. candidate at Lehigh, now a postdoctoral fellow at New York University Medical School — demonstrated for the
first time that synaptic inputs — the messages being sent between
cells — are distinct across frequencies and that these different impulse patterns are «mapped» onto the
cells of the cochlear
nucleus.
They then replaced one of a living yeast
cell's natural chromosomes with it — the
first time this had been done in more complex
cells with a
nucleus.
When they tracked the
cells» axons from the eye into the brain, they saw that many of them terminated in the lateral geniculate
nucleus (LGN), the
first relay station in the brain for visual information.
In the
first cell cycle after fertilization the maternal genome inherited from the oocyte (egg) and the paternal genome provided by sperm exist as separate
nuclei in the zygote.
The instructions for the synthesis of proteins are stored in the DNA in the
cell nucleus, are
first «transcribed» into mRNAs, and exported from the
nucleus to the ribosomes in the
cell cytoplasm.
The
first step was to insert an artificial chromosome containing the cumbersome human antibody gene into the
nucleus of a cow
cell.
The new finding brings a measure of closure to a story that
first rocked the science world in February 2004, when Hwang and colleagues at Seoul National University announced they had cloned a female donor's
cell by transferring its
nucleus into one of her egg
cells stripped of its
nucleus in a procedure known as somatic
cell nuclear transfer (SCNT), and harvested embryonic stem
cells from the resulting fusion.
Now, scientists at the Salk Institute and the University of California, San Diego, have for the
first time provided an unprecedented view of the 3D structure of human chromatin — the combination of DNA and proteins — in the
nucleus of living human
cells.
Scientists have determined the
first 3D structures of intact mammalian genomes from individual
cells, showing how the DNA from all the chromosomes intricately folds to fit together inside the
cell nuclei.
The
first mechanism can be discounted because it would require very large amounts of genetic information — much more than could be encoded in the entire complement of DNA in the
cell nucleus of each neuron.
This is the
first time to visualize the real time event of asymmetric
cell division, and we were able to see other events such as
cell elongation of the zygote and migration of the
nucleus.»
In 1996 researchers in Scotland used SCNT to transplant the
nucleus of an adult sheep
cell into an enucleated sheep egg, producing Dolly, the
first cloned mammal.
In the early 1950s, Robert Briggs and Thomas King repeated Spemann's experiments using a species of leopard frog, Rana pipiens,
first with a
nucleus from young embryos (Briggs and King, 1952) then from older embryos (King and Briggs, 1954); both the younger and older implanted
nuclei could still be reprogrammed by the enucleated host
cell.
This landmark revelation was the
first definition of an entire cellular signaling pathway from the
cell surface to the
nucleus, providing an important paradigm for understanding intracellular signaling.
When actin was
first discovered in the
cell's
nucleus several decades ago, it was dismissed as a contaminant.
While cloning has been deemed virtually impossible for many reasons, a team of researchers based at Texas A&M University were able to successfully complete the
first step towards cloning: the removal of the egg
cell's
nucleus (enucleation) 1.
A seventh paper provides a
first look at the three - dimensional structures of synthetic chromosomes in the
cell nucleus.
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Working in the dim light of an abandoned laboratory, a trainee technician with trembling hands embeds the DNA of a captured alien inside the
nucleus of a
cell extracted from the professor's own brain, and the
first of a squadron of Square Avengers is spawned.