Sentences with phrase «first clinical trial study»

Not exact matches

First, the topline numbers: The study was an observational one rather than a randomized control trial, the latter of which is considered to be the «gold standard» of clinical studies.

The 12 week clinical study from the US of 303 participants is the first prospective, randomised clinical trial to directly compare the effects of water and diet beverages on weight loss within a behavioural weight loss program.

The study comes on the heels of a 2013 clinical trial that showed rice protein paralleled whey protein in its ability to build muscle and improve strength and power for the first time.

This study is the first controlled clinical trial showing that fathers play a significant role in supporting successful lactation and increasing breastfeeding rates.

The 21 - patient study, sponsored by the nonprofit Multidisciplinary Association for Psychedelic Studies (MAPS), launched in 2004 as the first U.S. clinical trial of a psychedelic drug in 35 years.

In an effort to find out, Stephen P. Juraschek, M.D., Ph.D., research and clinical fellow in general internal medicine at the Johns Hopkins University School of Medicine, and his colleagues used data from the DASH (Dietary Approaches to Stop Hypertension) clinical trial, a widely popular and often - cited study whose results were first published in 1997.

In this new study and for the first time, scientists used functional magnetic resonance imaging (fMRI) combined with a standard clinical trial design to derive an unbiased brain - based neurological marker to predict analgesia associated with placebo treatment in patients with chronic knee osteoarthritis pain.

The first clinical trial of a drug intended to delay the onset of symptoms of Huntington disease (HD) reveals that high - dose treatment with the nutritional supplement creatine was safe and well tolerated by most study participants.

Once we have demonstrated the proof of concept in animal studies, the next goal will be to work towards the first human clinical trial with graphene devices during intraoperative mapping of the brain.

«While randomized clinical trials are needed to test whether this is a causal relationship, these findings indicate doctors should consider using or re-starting ACEIs and ARBs as first - line blood pressure medications for patients undergoing peritoneal dialysis,» said Jenny I. Shen, MD, an LA BioMed researcher and corresponding author of the study.

In my experience, this marks both the first clinical trial of an approved drug with an effect on survival in advanced melanoma in the adjuvant setting, and, in this same setting, the first to study an immune checkpoint inhibitor in the adjuvant setting.

The results of this study were first released in late 2016 at the international Clinical Trials on Alzheimer's Disease meeting in San Diego.

This study was the first major Alzheimer's clinical trial to require molecular evidence of amyloid deposition in the brain for enrollment.

The first - of - its - kind study found the dual treatments to be safe and elicit a clinical response in patients, according to new results from a phase I trial to be presented at the AACR Annual Meeting 2015 on April 19.

Since CGP3466B has already been tested in phase II clinical trials to (unsuccessfully) treat Parkinson's disease and ALS, it is known to be safe for humans, but the researchers caution that many more years of studies are needed to definitively show whether it is effective for preventing cocaine damage, first in mice, then in humans.

«This is the first study to look systematically at discontinuation and nonpublication of interventional pediatric clinical trials,» says Bourgeois.

The latest study builds off of work Kawai and his colleagues began fourteen years ago, when they launched the first clinical trial that attempted to use bone marrow to induce immune tolerance for kidney recipients, to avoid the sometimes dangerous side effects of life - long immosuppressive therapy.

Studies are now open to recruit patients with metastatic breast cancer across Europe — these studies will first extend the analysis performed here to many more patients, but the ultimate goal is to build a platform for identifying an appropriate clinical trial of new treatments for each patient with metastatic breast Studies are now open to recruit patients with metastatic breast cancer across Europe — these studies will first extend the analysis performed here to many more patients, but the ultimate goal is to build a platform for identifying an appropriate clinical trial of new treatments for each patient with metastatic breast studies will first extend the analysis performed here to many more patients, but the ultimate goal is to build a platform for identifying an appropriate clinical trial of new treatments for each patient with metastatic breast cancer.

Dr. Gonzalo Pizarro, one of the first authors on the study, comments that «it has been possible to demonstrate the beneficial and sustained effect of this acute treatment thanks to the realization of advanced cardiac magnetic resonance analysis of almost all the patients in this clinical trial.»

The first, by researchers based in the UK, Europe and USA, examined data from observational studies and clinical trials (an umbrella review) to summarisze health outcomes associated with vitamin D levels, both naturally circulating and as a result of taking supplements.

In December 2009, Summers became the first patient enrolled in a clinical trial of a method pioneered in studies with rodents and cats by Edgerton and others.

«These results enable us to determine whether potential treatments will be effective against patients» symptoms by testing them first in healthy volunteers and defining the best doses based on objective physiological data before conducting costly clinical trials,» said Jeffrey Lieberman, MD, the Lawrence C. Kolb Professor and Chairman of the Department of Psychiatry at CUMC, and Principal Investigator of this study.

Earlier observational studies had shown a similar impact of ARVs reducing sexual transmission in heterosexual couples, but this was the first to demonstrate the prevention power of the drugs in a randomized, controlled clinical trial.

Hence, a total of 90 patients from nine centers were randomly assigned to one of two study arms for the phase II clinical trial: the first taking capsules of olaparib (400 mg twice daily) and the other taking a combination of the two drugs (200 mg olaparib in capsule - form twice daily and 30 mg tablets of cediranib once daily).

Clinical trials are currently trying to do just this in multiple cancer types, but this is the first study that has shown that it might also work for colon cancer.

«We hope our findings reassure women with epilepsy and clinicians who are counseling these women on family planning,» says Jacqueline French, MD, professor of Neurology and Director of Translational Research and Clinical Trials at NYU Langone's Comprehensive Epilepsy Center, and the study's first author and co-principal investigator.

UNITY has completed a rigorous screening and preclinical testing process of candidate drugs, discovered in this study, and is launching a new clinical trial to assess its first drug, for patients with osteoarthritis of the knee this year.

Dr. Fish also pointed out that the onsite team for this pilot study was composed of 11 Guinean healthcare workers who received, for the first time, relevant training in all aspects of conducting a clinical trial according to international standards.

Additional limitations to the traditional approach include: costly failures to replicate positive results in larger trials; difficulty in determining the reasons for negative results; low yield in terms of identifying disease or intervention mechanisms due to an exclusive focus on symptom change and clinical endpoints; and, the expensive and very lengthy practice of first establishing multi-component psychosocial treatments followed by years of «unpacking» studies.

«This is the first human trial of this novel stem cell - based implant, which is designed to replace a single - cell layer that degenerates in patients with dry age - related macular degeneration,» says lead author and surgeon for the study Dr. Amir H. Kashani, assistant professor of clinical ophthalmology at the Keck School of Medicine of USC.

In the $ 1.47 million, four - year grant called â $ œBiomarkers of Ischemic Outcomes in Intracranial Stenosisâ $ (BIOSIS), Emory researchers are analyzing blood samples from 451 patients from around the country who were enrolled in a study known as SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis), the first randomized, multicenter clinical trial designed to test whether stenting intracranial arteries would prevent recurrent stroke.

This experimental vaccine regimen is based on the one tested in the U.S. Military HIV Research Program - led RV144 clinical trial in Thailand — the first study to demonstrate that a vaccine can protect people from HIV infection.

Andy has over 10 years of experience in clinical trial management, specializing in early phase, first - in - human, global studies.

The first clinical trial was a safety study in Australia, followed by an ongoing efficacy study in Peru to evaluate the ability to treat patients with malaria.

Led by Waisman Center and College of Agricultural and Life Sciences investigator Denise Ney and her graduate student Bridget Stroup, the study represents the first human clinical trial to compare how different PKU - specific diets affect the bone health of people living with the disease.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

Washington University neurologist and study lead Dr. Randall Bateman says this is one of the first clinical trials to try to treat Alzheimer's patients before they have any symptoms.

For example, Dr Masayo Takahashi's macular degeneration study at the RIKEN Centre for Developmental Biology (Japan) is research, whereas our study is the first clinical trial of its kind.

Building on the findings of an earlier study that found for the first time, albeit modestly, that a vaccine could prevent HIV infection in 2016, an NIH - supported clinical trial was launched to test a modified HIV vaccine.

That study is used as a recruitment database for clinical trials and is the first place the teams will look once recruitment begins.

A University of California at Los Angeles (UCLA) study headed by Antoni Ribas, M.D., Ph.D., is a first - in - human phase I clinical trial combining adoptive cell transfer of a T cell receptor engineered to recognize NY - ESO - 1 along with Yervoy ® (ipilimumab, anti-CTLA-4).

Its Clinical Trials Center conducts 13 - 15 clinical studies per year, and in December initiated a Phase 2 clinical trial of an Ebola vaccine following its groundbreaking first - in - human testing of the Ebola vaccine that showed efficacy in Guinea laClinical Trials Center conducts 13 - 15 clinical studies per year, and in December initiated a Phase 2 clinical trial of an Ebola vaccine following its groundbreaking first - in - human testing of the Ebola vaccine that showed efficacy in Guinea laclinical studies per year, and in December initiated a Phase 2 clinical trial of an Ebola vaccine following its groundbreaking first - in - human testing of the Ebola vaccine that showed efficacy in Guinea laclinical trial of an Ebola vaccine following its groundbreaking first - in - human testing of the Ebola vaccine that showed efficacy in Guinea last year.

• Study achieves primary endpoints; DG031 shown to be well - tolerated and to significantly reduce levels of leukotriene B4 and myeloperoxidase • First ever clinical trial based upon the isolation of a disease gene in a common disease

We also participate in several national and international clinical trials including First - in - Man applications as well as first - in - class stuFirst - in - Man applications as well as first - in - class stufirst - in - class studies.

REVEAL - SCAN: Risk Evaluation and and Education of Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (RF1 AG047866) is the first multi-site, randomized clinical trial to examine the impact of learning amyloid imaging results in cognitively normal individuals, and its goal is to answer these questions.

• Study achieves primary endpoints; DG031 shown to be well - tolerated and to significantly reduce levels of leukotriene B4 and myeloperoxidase • First ever clinical trial based upon the isolation of a disease gene in a common disease Reykjavik, ICELAND, October 19,...

Study in partnership with the Alliance for Clinical Trials in Oncology is the first large controlled trial to show overall survival benefit in FLT3 - mutated AMLAML is the most common acute leukemia in...

Suzanne L. Topolian, MD, of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University in Baltimore, moderated the press conference on Tuesday, and she noted that epacadostat is being studied «in literally dozens of clinical trials,» though the ECHO - 203 study marks the first data on administration of this agent in combination with an anti — PD - L1 inhibitor.

The first - of - its - kind study found the dual treatments to be safe and elicit a clinical response in patients, according to new results from a phase I trial to be presented at the AACR Annual Meeting 2015 on Sunday, April 19 (Abstract #CT137).

First, most of the evidence regarding the disease effects of carbohydrate to fat ratio is derived from epidemiological and observational studies because it is difficult to address disease endpoints through clinical trials.