Sentences with phrase «first exon»

Huntington disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded CAG trinucleotide repeat in the first exon of the HD gene, which results in a toxic polyglutamine stretch within huntingtin, the protein it encodes.

To generate a reporter cell line that gives real time read outs of low - level early endodermal gene expression, we introduced a synthetic internal ribosomal entry site (IRES) designed to amplify translation upstream of a fluorescent reporter [31] into the first exon of the Hex genomic locus (Figure 1A).

The capital letters represent the first exon of the RIG - G gene.

Hex cDNA tagged with a recognition site for the bacterial BirA ligase (B), followed by an artificial IRES sequence composed of a tandem array of reiterated 9 bp elements from the Gtx promoter and DNA encoding the fluorescent reporter, Venus, was inserted into the first exon of the Hex locus.

The first exon and the intron of BMP12 were not present in the available genome sequence.

Degree of methylation of CpG residues on the first exon of TNF will be intercorrelated, indicating coordination of methylation across the first exon, and indicating that an index of methylation of the first exon for TNF results in a reliable construct.

Because methylation of CpG islands associated with the first exon is particularly predictive of gene expression (e.g., Plume et al., 2012), characterizing individual differences in methylation of inflammation - related genes in the region of the first exon may be particularly informative.

Eight CpG sites were identified as being associated with the first exon of TNF.