(1996)
The first gene for idiopathic epilepsy: a fruitful collaboration of Australian clinical research and molecular genetics.
A: At the time, ideas were beginning to form about which drug compounds to test —
the first gene for ALS had been identified two years earlier — but ALS wasn't grabbing the attention of the pharmaceutical industry.
«
First gene for grey hair found.»
But medical genetics hit a new high point last week, when two groups working independently announced that they had isolated
the first gene for a common form of cancer.
Not exact matches
The
first gene therapy in the U.S. now has a price tag: $ 850,000
for the one - time treatment, or, more specifically, $ 425,000 per eye
for a retinal disorder.
This week,
for the
first time, a hospital edited the
genes of a patient, to cure him, one hopes.
And on Wednesday, in a major milestone
for this burgeoning and potentially world - changing industry, the Dutch startup UniQure, developer of the Western world's
first approved
gene therapy, raised $ 82 million in its initial public offering, Reuters reports.
Right now, the
first CRISPR
gene therapies are in development, but they are not built on a «standard stack» and require a lot of custom work
for each indication - these therapies will be coming into the clinic and hopefully get approved the coming couple years, and after that there could be significantly more investment into standard tools.»
Approved treatments included
gene therapies and the
first new drugs
for rare diseases in many years.
Last month, Novartis AG (NOVN.S) won U.S. approval
for the
first of a new type of potent
gene - modifying immunotherapy
for leukemia, a $ 475,000 treatment that marks the start of a potential new treatment paradigm
for some cancers.
Angling to be the go - to marketplace
for these
gene - based businesses, Helix, the spin out from genetic testing research and technology giant Illumina, has held a
first close on a planned $ 200 million funding round led by new investor DFJ Growth.
The
first steps in this have already been accomplished with the transplanting of additional
genes for growth hormone into sheep in Australia to produce larger animals and therefore more wool.
Evolution occurs when the offspring differ from the parent's genetics, so a bird that was almost a chicken laid an egg with the
genes for the «
first» chicken.
The early modern evangelicals were possessed of a marvelous insight: that religion in their world was at last, and virtually
for the
first time in history, no longer to be passed through the
genes.
As a Howard Hughes Medical Institute investigator and biochemistry professor at Stanford, Pat led a team that developed the
first methods
for analyzing, visualizing and interpreting global
gene expression programs.
Gene Biggi
first developed his palate
for developing unique specialty condiments from his mother Rose's kitchen as a kid.
When he stands in the
first or third base box, yelling, sleeping, blowing kisses, spraying water, there is an actual baseball game going on, and some managers —
Gene Mauch and the late Paul Richards,
for instance — tried at various times to keep Max from taking the field.
Despite her parents both having professional sports experience — Franklin Edwards, Alexa's father, was a
first - round draft pick of the Philadelphia 76ers and won an NBA Championship in 1983 — she says that they passed along athletic
genes and a love
for the court, but never pressured Alexa to follow their paths in athletics.
TRADED: Red Sox Shortstop RICK BURLESON, 29, and Third Baseman BUTCH HOBSON, 29, to the Angels
for Pitcher MARK CLEAR, 24, Third Baseman CARNEY LANSFORD, 23, and Outfielder RICK MILLER, 32; Pirate Righthander BERT BLYLEVEN, 29, to the Indians along with Catcher MANNY SANGUILLEN, 36,
for four players; Third Baseman KEN REITZ, 29, Outfielder LEON DURHAM, 23, and Infielder TY WALLER, 23, of the Cardinals
for Cub Reliever BRUCE SUTTER, 27; St. Louis Catcher TERRY KENNEDY, 24, and six other players to the Padres
for Pitcher ROLLIE FINGERS, 34,
First Baseman
GENE TENACE, 34, Pitcher BOB SHIRLEY, 26, and Catcher BOB GEREN, 19; Fingers, Cardinal Catcher TED SIMMONS, 31, and Pitchers PETE VUCKOVICH, 28, and DAVE LA POINTE, 21, to the Brewers
for Outfielder SIXTO LEZCANO, 27, and Pitcher LARY SORENSON, 25; and Texas Outfielder RICHIE ZISK, 31, pitcher KEN CLAY, 26, and four other Rangers and cash to Seattle
for Pitcher RICK HONEYCUTT, 28, Outfielder LEON ROBERTS, 29, and two others.
At the ninth in the
first round,
Gene Littler, who tied
for second with the 40 - year - old Australian, Kelvin Nagle, had a 100 - yard holeout
for an eagle deuce.
Whether or not a child is born with this special
gene, you can take advantage of the
first few years of your baby's life, which experts believe is an optimal period
for learning.
Although my mom would always tell me that I would be a good mom like her someday, I guess I am left to say that she was right, it may have something to do with
genes, but at the end of the day, when the time came, I was ready to be a Mom and that meant providing the best
for my child, the
first and foremost — to breastfeed my child.
If in the
first 10 days of life you have a low nurturing rat mother (the equivalent of the
first 6 months of life in a human), the
gene never gets turned on and the rat is anxious towards new situations
for the rest of its life, unless drugs are administered to alleviate the anxiety.
The desire to raise intelligent and healthy children is entrenched in our
genes, and
for most of us successful breastfeeding is our
first parenting goal.
Scientists reported selectively altering
genes in viable human embryos
for the
first time this year.
Nearly five years after the
gene - editing tool debuted, researchers
for the
first time have used it to alter
genes in viable human embryos.
POISONED BY MOM A C. elegans nematode that inherits a
gene for the antidote to a maternal toxin grows a normal feeding tube (shown
first).
In 1980 Fiers
first sequenced the
gene for hemagglutinin derived from the human influenza strain H3N2 that circulated in 1965.
They show
for the
first time that orphan
genes are frequently lost and consider the factors the influence the «survival» of the young
genes.
Previous studies have reported changes to the brain while people practise these activities, but a new study shows
for the
first time that
gene activity changes too.
«The most exciting thing is this is really the
first gene we can point at than can be used
for therapy,» she says.
Now her team has analysed the immune system's key controller
genes for the
first time and found that resistant devils have
genes that equip them to attack the disease (Proceedings of the Royal Society B, DOI: 10.1098 / rspb.2009.2362).
The causative
gene for Huntington's disease, HD, one of the
first genes identified to cause an inherited disease, is located on chromosome 4.
For the
first time, specialised cells have been reprogrammed into the equivalent of embryonic stem cells without using
genes that might trigger cancer.
First, the
genes used
for reprogramming are themselves known to trigger cancer, so if they were to reactivate could cause tumours to form.
First, they did a quantitative analysis of the anatomy of related fossils and extant animals to generate a hypothesis about the transition; next, they searched
for possible shifts in
gene expression that correlated with the transition.
The phase 1 clinical trial is the
first to test the functional replacement of the mutated
gene responsible
for SMA1.
The researchers identified
for the
first time master
genes that they believe control hundreds of other
genes which are linked to Alzheimer's disease, Parkinson's disease, post-traumatic stress disorder, stroke, attention deficit hyperactivity disorder, autism, depression, schizophrenia and other disorders.
The remaining $ 85 million will be split equally among five scientists who
first cloned the
gene for human growth hormone.
The results show —
for the
first time, Briggs thinks — that the bacterial genomes change with depth: the micro-organisms at 554 metres carry more mutations in
genes that code
for energy - related processes like cell division and biosynthesis of amino acids than are seen in their shallower counterparts.
Base oxidation regulates
gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown,
for the
first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.
For this technique to work, the animals
first have to undergo
gene therapy four weeks before the device is implanted.
Ishii notes that if the clinical trial begins as planned, it would be the latest in a series of
firsts for China in the field of CRISPR
gene editing, including the
first CRISPR - edited human embryos, and the
first CRISPR - edited monkeys.
The policy — in the form of
first Office Actions on a series of applications
for patents on expressed sequence tags, ESTs — could greatly complicate basic
gene therapy research by substantially allowing patents
for small sequences of a
gene that may later be used by the patent holder to corner ownership and uses of entire
genes.
The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the
first to test the idea of stimulating the immune system's killer T cells to hunt
for the virus more aggressively, in this case using a weakened form of the cold virus to carry three
genes from HIV.
FOR the
first time, an imprinted
gene has been shown to have different functions depending on whether it is inherited from the mother or father.
For the
first time, the response of more than 10,000
genes was followed simultaneously, which identified brassinosteroids and auxins and their signalling molecules as key to the growth stimulation observed in biochar.
In science news around the world, NASA's Cassini mission is about to take its final plunge into the atmosphere of Saturn after 13 years providing an unprecedented view of the planet and its moons, a fight over whether to preserve or develop of one Europe's oldest gold mining sites heats up again, the U.S. Food and Drug Administration approves the
first cancer
gene therapy
for people, a U.S. court gives a green light to a $ 1 billion lawsuit brought by the Guatemalan victims and survivors of mid — 20th century syphilis experiments by research institutions including Johns Hopkins University, and more.
For the
first 6 months of the trial, participants were randomized into two groups, regardless of
gene status.
Scientists have discovered the
first example of a
gene solely responsible
for an autoimmune disease, a type of disorder in which the immune system attacks the body.