Sentences with phrase «first gene found»

Smed - beta - catenin - 1 is the first gene found to be required for this regeneration polarity.»

In a paper published in the online edition of Nature Genetics, a deCODE - led team of scientists describes the identification of the first gene found to confer significant risk of the common form of heart attack.

This is not the first gene found to affect an organism's life - span.

Not exact matches

«Once I did the DNA test it linked me to people in their database with the closest gene pool, and it found my aunt and first cousin!»

She plans to find the genes at play in the first few days of fertilisation when an embryo develops a coating of cells that later become the placenta.

Findings from a study into Crohn's disease, led by William G. Kerr, Ph.D., of SUNY Upstate Medical University, and his collaborators at the Erasmus Medical Center in the Netherlands, provide the first evidence that patients with debilitating inflammatory bowel disease lack sufficient quantities of a protein that comes from the SHIP1 gene.

The artist of this depiction, Raquel Lieberman, is the principal investigator of the team that confirmed a Y - shaped structure, the first ever found that was encoded as such by a gene and not constructed out of protein component parts.

While many humans today carry bits of Neandertal DNA, this is the first time human DNA has been found embedded in a Neandertal's genes.

Orphan genes were first discovered in the fruit fly but are found in all organisms, including man.

He has already started mapping the first 500 and estimates that by mid-2008 the world will know where — if anywhere — to find the gay gene.

Valway and colleagues say they have already found a stretch of DNA that distinguishes this strain of TB from others — a first step toward finding such genes.

Now her team has analysed the immune system's key controller genes for the first time and found that resistant devils have genes that equip them to attack the disease (Proceedings of the Royal Society B, DOI: 10.1098 / rspb.2009.2362).

The study found that in the 18th and 19th centuries, about four to 18 per cent of the variation between individuals in lifespan, family size and ages at first and last birth was influenced by genes, while the rest of the variation was driven by differences in various aspects of their environment.

One route, first suggested by Burt in 2003, is to release a sequence that is resistant — effectively unrecognizable — to the guiding enzyme that finds cuts of DNA in a gene drive.

These findings mark the first time any Alzheimer's genes have been picked from the proverbial haystack in genomic studies.

In today's issue of Cell, a team reports that it has found in mice and humans a close relative of a fruit fly clock gene — the first evidence that some of these genes may have been conserved over the course of evolution.

Biochemist Radhey Gupta of McMaster University in Canada proposes that a bacterium and an archaean fused to form the first eukaryote, based on his analysis of a pair of slow - changing genes found in what may be one of the oldest cells with a nucleus, Giardia lamblia.

Face shape, which would be the holy grail, is in the distant future — we've only found the first five genes, and the effects of those genes are very small.

The first clue that digits and penises might be birds of a feather came in 1991, when a team led by developmental biologist Denis Duboule of the University of Geneva and Pierre Chambon of the Institute for Genetics and Molecular and Cellular Biology in Strasbourg, France, found that some mice with a mutated gene, called hoxd13, had abnormally small digits and malformed penises.

We did not find any evidence for a so - called «positive selection» but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place.

Indeed, the group found that the affected gene, named left - right dynein (lrd), comes on in the «node» — a key source of patterning signals — just before the appearance in the mouse embryo of the first known left - right asymmetries, the left - sided expression of two genes called nodal and lefty.

In fact, Shatz observed no actual MHCI proteins when she first examined those fetal cat LGNs; what she found were biochemical signs indicating that MHCI genes were active.

The first direct evidence has been found linking smoking to epigenetic changes in genes that help fight cancer.

A variant form of the gene was first noted in humans in a Hawaiian study of long - lived men of Japanese ancestry and has since been found in long - lived Germans, Italians, Ashkenazi Jews, and Chinese.

«First, we had to figure out much better methods to find human counterparts of yeast genes, and then we had to arrange the humanized set of genes in a meaningful way,» explained Peng, now Assistant Professor of Computer Sciences at University of Illinois, Urbana - Champaign.

One set of CRE genes was first seen in India in 2009 and has since been found around the world.

The researchers then compared the expression of all genes in six parts of the brain of the two bird species using state - of - the - art molecular techniques, including next - generation sequencing — the first time these tools have been used to find brain properties related to innovation and problem - solving in wild birds.

McMahon says that although numerous small studies have attempted to find genes implicated in antidepressant action, this is «by far the largest» as well as the first to yield a «strong and reproducible signal.»

The findings, which will be published April 28 in Cell Metabolism, highlight the importance of two genes not previously implicated directly in pancreatic function, and show that the pancreas continues to develop and mature during the first decades of life.

First author Kim Martinod, a graduate student in the Immunology Graduate Program at the Harvard University Medical School, found that, in response to vein constriction, these «rescued» mice now could function normally, forming clots as efficiently as mice with a functioning Pad4 gene, demonstrating that the Pad4 gene did produce a functioning PAD4 enzyme in these white blood cells to regulate blood clotting.

Until now, de novo genetic mutations, alterations in a gene found for the first time in one family member, were believed to be mainly the result of new mutations in the sperm or eggs (germline) of one of the parents and passed on to their child.

First, the team used a gene hunting method known as PCR to find out which types of bacteria were most commonly found among the women in the study.

First, looking at a study of 185 cases of childhood epilepsy, Wittkowski's team found that mutations in genes that control axonal guidance and calcium signaling — both of which are important early in the developing brain when neurons are forming the appropriate connections — led to increased chances of having the disorder.

Pinker says that the findings are a first step in demonstrating that intelligence relies on large numbers of genes, each with a tiny effect, rather than on single genes that have moderate or large effects, but which are so rare that none has yet been identified.

The Liverpool - led team found that this colour change was produced by a mutation in the cortex gene, which occurred during the mid 1800s, just before the first reported sighting of black peppered moths.

First author Professor Martin Hrabe de Angelis, Director of Institute of Experimental Genetics at the Helmholtz Zentrum München, who invented the mouse clinic concept, said: «Our findings with regard to the genes examined are now available to the scientific community as a valid data set, which can be downloaded free of charge from the IMPC (International Mouse Phenotyping Consortium) website, and form an excellent basis on which we and other research groups can develop and test new hypotheses.»

More than two decades ago, in one of the first papers using gene sequences to find signatures of natural selection, scientists hypothesized that a molecular change in an enzyme gave the Drosophila melanogaster fruit fly species its superior ability to metabolize alcohol.

They found that cancer cells had acquired new genetic changes that cancelled out the original errors in DNA repair — particularly in the genes BRCA2 and PALB2 — that had made the cancer susceptible to olaparib in the first place.

«Based on our findings, we think mice with these ASD - associated gene mutations have a major defect in the «volume switch» in their peripheral sensory neurons,» says first author Lauren Orefice, a postdoctoral fellow in Ginty's lab.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

To find out more about the differences between naive and primed pluripotent cells, the UW researchers first compared their gene expression profiles.

The researchers found that S. aureus acquired the gene that confers methicillin resistance — mecA — as early as the mid-1940s — fourteen years before the first use of methicillin.

«By understanding the gene networks that get disrupted in CAVD, we can pinpoint what we need to fix and find new therapeutics to correct the disease process,» says first author Christina Theodoris, an MD / PhD student at the Gladstone Institutes and UCSF.

Ahmer and colleagues found this important food source by first identifying the genes that Salmonella requires to stay alive during the active phase of gastroenteritis, when the inflamed gut produces symptoms of infection.

The study is «a real feat,» says Sven Andersen, a molecular biologist at the University of Copenhagen, Denmark, and part of the team that first found the resilin gene.

The gene isn't active on the other side of the wing, they found, because Engrailed - 1, another gene first found in flies, suppresses it.

When the first results confirmed that we had indeed found a new resistance gene, I was really excited.»

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

The study of almost 8,000 families, published today (21 March) in Nature, found for the first time that mutations outside of genes can cause rare developmental disorders of the central nervous system.