Sentences with phrase «first human patient»

Chapter 1: Choosing Our Bodies Gene therapy from Ashanti DeSilva (the first human patient) to boosting strength, speed, and stamina.

Not exact matches

In 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancer.

Johnny Ray, who died on this date six years ago, was Kennedy's patient, his research subject, and the world's first human cyborg, fitted with brain implants that allowed him to communicate directly with a computer.

The first - in - human PET / CT imaging of 75 patients with 18F - MPG was performed to show that this tracer can be used as a companion diagnostic to identify NSCLC patients with EGFR activating mutant tumors (primary tumor or metastatic) with 84.3 % accuracy.

They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a measure of spatial memory which is impaired in other animal models of concussion and human patients.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

«The ABICABAZI trial puts these ideas to the test in humans, and if we are correct, has the capacity for the first time to tell us what patients might most benefit from chemotherapy.»

Clinicians treating patients suffering from Middle East respiratory syndrome (MERS) currently have no drugs specifically targeted to the MERS coronavirus (MERS - CoV), a virus first detected in humans in 2012 that has since caused 614 laboratory - confirmed infections, including 181 that were fatal, according to the World Health Organization.

2015 will see the start of the first human clinical trial of a gene silencing or huntingtin - lowering drug, which specifically aims to reduce production of mutant huntingtin in the brains of HD patients.

The students» prototype, developed during a yearlong biomedical engineering master's degree program, has not yet been tested on humans, but it is viewed as a promising first step toward helping Parkinson's patients safely relieve their own symptoms at home or elsewhere without going to a hospital or doctor's office.

These images provide the first 3D ultrastructural details on HIV infection and virus production in a setting that closely resembles the gut of human patients.

The team at UF's Powell Center for Rare Disease Research and Therapy conducted the first in - human study of gene therapy to treat respiratory dysfunction in patients with infantile onset Pompe.

But to try the treatment in patients, they will have to identify the mouse proteins» human equivalents first.

An antibody engineered to prevent excessive bleeding in patients with severe hemophilia A may be safe and effective, and require fewer injections than existing options, according to a first - in - human study of the treatment published online today in Blood, the Journal of the American Society of Hematology (ASH).

«This is the first study advancing barrier repair that treats symptomatic mice, which more closely mirrors conditions for human patients,» Dr. Garbuzova - Davis said.

«Antibody for severe hemophilia a may reduce injections needed to prevent bleeding: First - in - human study of ACE910 suggests excessive bleeding prevention is possible with a weekly subcutaneous injection compared to standard two or three intravenous injections every week, and should be effective in treating patients with inhibitors.»

Liv Bode, a virologist at the Robert Koch Institut in Berlin whose team was the first to isolate the virus from patients, welcomes the findings as a «solid piece of work that fits the picture and lends further support to the existence of human [strains of] BDV.»

The study was the first to create human Purkinje cells using TSC patients» own stem cells.

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better vision.

«Based on this research, we are now conducting a first - in - human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced pancreatic cancer, with an ultimate goal of improving survival rates and treatment outcomes,» said Tuli.

One team in Japan, and another in the US, have independently shown it is possible to produce embryonic - like stem cells directly from a patient's own skin cells without having to create and destroy a cloned human embryo first.

The lawsuit against Myriad Genetics and the University of Utah Research Foundation, which hold the patents on the genes, charged that the challenged patents are illegal and restrict both scientific research and patients» access to medical care, and that patents on human genes violate the First Amendment and patent law because genes are «products of nature.»

«This is the first human trial of this novel stem cell - based implant, which is designed to replace a single - cell layer that degenerates in patients with dry age - related macular degeneration,» says lead author and surgeon for the study Dr. Amir H. Kashani, assistant professor of clinical ophthalmology at the Keck School of Medicine of USC.

Our team was instrumental in the development of talimogene laherparepvec, the first in human oncolytic virus therapy for patients with melanoma.

Geron became the first company to start clinical trials of embryonic stem cells in humans, starting with a patient who had spinal cord injuries.

About OpenBiome OpenBiome is the first public stool bank, founded to expand safe access to fecal transplantation for patients with recurrent C. difficile infection and to catalyze research on the microbiome's role in human health.

Daniel Speiser, Pedro Romero, and colleauges report the first demonstration in humans that a synthetic vaccine can rapidly elicit strong specific CD8 + T cell responses in a majority of patients.

Which patient groups should be asked to participate in first - in - human trials of stem cell - based therapies?

Researchers at UCLA treat the first patients in the second FDA - approved study evaluating a therapy made from human embryonic stem cells.

In 1988, Freed and his colleague Robert Breeze, MD, performed the first transplant of human fetal dopamine cells into a Parkinson's patient in the United States.

Russell Kern reports on the 6 - month update on the first - in - human clinical study of neural stem cells in patients with Parkinson's disease.

The Human Trial is following one research team and a handful of trial patients as they move from the lab through the first two years of the Phase 1/2 clinical trial.

Researchers have treated the first two patients in the second government - authorized attempt to evaluate a therapy created using human embryonic stem cells in the United States.

The first trials would primarily assess safety but would also begin to probe what really happens inside a human heart, perhaps through testing in patients scheduled for heart transplantation, allowing scientists to study their old hearts post-transplant.

October 13, 2016 Researchers help paralyzed man regain sense of touch through a robotic arm For the first time ever, a human patient is able to experience the sense of touch through a robotic arm that he controls with his brain, with the help of technology created by researchers from Pitt and UChicago's Sliman Bensmaia.

All six patients suffered from end - stage heart disease and were enrolled in this first - in - human (FIH) clinical trial, approved by the U.S. Food and Drug Administration in late 2015.

«Our approach allowed us to grow human neurons in a dish that contained the exact same mutation as the neurons in the brain of the patient,» explained first author Helen Fong, PhD, who is also a California Institute for Regenerative Medicine postdoctoral scholar.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

He and his colleagues were the first to demonstrate that human antigen - specific T cell clones could be isolated and expanded in vitro and then re-infused into patients to prevent or treat viral infections and to mediate therapeutic responses in patients with cancer.

The first patients to receive human embryonic stem cell transplants say their lives have been transformed by the experimental procedure

In the several years since those first reports, new advances in the derivation of hiPSCs from various tissue sources (including those from human patients) and using diverse reprogramming techniques, and in their use as a pluripotent cell source in the induced differentiation of a wide array of somatic cell types, have appeared with almost startling rapidity.

She was the Director of the Center for Human Genetics from 2000 to 2008, Medical Director of the Clinical Cancer Genetics program from 1995 to 2012, and founded the first specialized clinic for delivery of genetic services to patients and families with hereditary cancer susceptibility in Northeastern Ohio.

Yerkes National Primate Research Center researchers are the first to show that an irradiation plus transplantation combination approach in nonhuman primates can be used to treat or even possibly cure HIV / AIDS, and this new model is providing some answers about the «Berlin patient,» the only human thought cured of AIDS.

Details of a first - in - human case report showed that a patient with melanoma was able to achieve a durable complete response with the combination of two types of immunotherapy.

In the first of the two new studies, Lobo and his team showed that they could obtain lung spheroid cells from human lung disease patients with a relatively non-invasive procedure called a transbronchial biopsy.

While this first study was done on rats, a previous study performed by Safarinejad studied stinging nettle's effects on BPH in human patients.

At first, I had difficulty believing what I was reading, but it's true and you can read more information about the study on clinicaltrials.gov: Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten - sensitivity.

I am currently working to complete my master's degree in Human Nutrition and Functional Medicine from the University of Western States, a science - based and patient - centered approach to health that focuses on treating the person by first assessing the underlying cause of disease.

April 18, 2018 • The first single from the metal band's fourth album, Ordinary Corrupt Human Love, offers a gift for the patient Deafheaven listener.

Laser therapy was first used on human patients and now it is gradually being adapted as a valuable component of veterinary technology.