Sentences with phrase «first key protein»

We identified Protein Kinase C - theta as the first key protein that serves as master switch for determining the physiological outcome to initial T cell activation.

Not exact matches

It first started with the original Cheesecake Protein Bars, then was the Peanut Butter Chocolate Cheesecake Protein Bars, then Lemon Cheesecake Protein Bars, then Coconut Cheesecake Protein Bars and finally Key Lime Cheesecake Protein Bars.

Seasoning the first layer onto the protein and then the last layer or I should say the first layer you taste, is key to that saying, it has depth of flavor.

The subject of lowering heavy metals in plant - based foods has been a key initiative addressed by Axiom Foods since Oryzatein ® brown rice protein was first USDA organic certified in 2009.

«Breast milk continues to provide substantial amounts of key nutrients well beyond the first year of life, especially protein, fat, and most vitamins.»

«Our results show, for the first time, that these two proteins — a receptor and its corresponding binding protein — play a key role in the progression of rheumatoid arthritis pathology,» said Shiva Shahrara, associate professor of rheumatology at UIC.

A third group first got an injection of a compound known to block the effects of interleukin - 1 beta (IL - 1), a protein involved in activating the inflammatory immune response and shown in previous research to be a key player in modulating fetal brain injury following exposure to inflammation in the womb.

Dr. Menko, together with first author Caitlin Logan, MD, PhD, and second author Caitlin Bowen, was looking at a mouse that had been engineered to stop producing a key developmental protein called N - cadherin just as the lens was beginning to form.

The first study used fruit flies as an in vivo test system to reveal new evidence about the function of a key influenza protein called NS1, which has evolved to target molecular pathways in the host.

In a paper published this week in Current Biology, postdoctoral fellow David Kast, PhD, and professor Roberto Dominguez, PhD, and three other colleagues from the Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania, show for the first time that the formation of ephemeral compartments key in this process require actin polymerization by the Arp2 / 3 complex, a composite of seven proteins.

Dr. Espen Spangenburg, associate professor of kinesiology, and his laboratory team are the first to identify that the BRCA1 protein is expressed in the skeletal muscle of both mice and humans, and that it plays a key role in fat storage, insulin response and mitochondrial function in skeletal muscle cells.

For example, it revealed for the first time that one region of a kinase called CheA (KEY aye), changes its orientation in relation to the other proteins, in a motion the researchers call «dipping.»

It's helped Bertozzi capture the first images of glycoproteins, proteins coated with sugars that play a key role in diseases such as cancer.

To visualize translation, Dr. Singer and his colleagues took advantage of a key occurrence during the first round of translation: the ribosome to which mRNAs attach must displace so - called RNA - binding proteins from the mRNAs.

In 1988, Scheller identified the first key vesicle membrane protein, which he termed VAMP, now also known as synaptobrevin.

The next major advance which moved this analysis from a cell physiological to a molecular level was accomplished by Scheller and Südhof who made overlapping contributions that characterized the proteins that controlled the two key steps of transmitter release: 1) They showed the mechanism by which the vesicle is mobilized to the release sites of the presynaptic terminal, where the synaptic vesicle first fuses with the membrane of the sending neuron and then leaves the cell, and 2) they also discovered how Ca2 + drives the vesicle to release its contents.

The team used genome editing techniques to stop a key gene from producing a protein called OCT4, which normally becomes active in the first few days of human embryo development.

The first - ever high - resolution 3 - D maps of HPV reveal key characteristics of its outer shell, or capsid, and the proteins that assemble it.

Scientists in the lab of Whitehead Institute Member David Sabatini have for the first time identified a protein that appears to be a nutrient sensor for the key growth - regulating mTORC1 metabolic pathway.

The first one plays a key role in the assembly of complex I, the first of a series of protein complexes used to create ATP.

First, Nanog opened two key cellular pathways, known as Rho - associated protein kinase (ROCK) and Transforming growth factor beta (TGF - β).

With the discovery of Asgard» clade archaea, the homologs of key eukaryote cytoskeletal proteins have, for the first time, been identified in archaea.

Aging and the apoE4 protein combine to impair inhibitory neurons in the hippocampus — a key memory center that is among the first regions affected by Alzheimer's.

However, a few years ago, scientists in the Lodish laboratory found a protein, termed FATP (Fatty Acid Transport Protein), that plays a key role in transporting a vital fatty acid nutrient into heart muscle; this protein was the first known fatty acid transprotein, termed FATP (Fatty Acid Transport Protein), that plays a key role in transporting a vital fatty acid nutrient into heart muscle; this protein was the first known fatty acid transProtein), that plays a key role in transporting a vital fatty acid nutrient into heart muscle; this protein was the first known fatty acid transprotein was the first known fatty acid transporter.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theProteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets theproteins in cancer, and their usefulness as drug targets themselves.

The first key to revving - up metabolism is eating a whole foods diet: lean protein, high quality grains, plant - based fats and oils, fresh fruits and veggies, and drinking lots of water.

«However, the animal protein component is the first place to look because animal proteins are key ingredients in pet food recipes and thus contain the biggest percentage of proteins,» she added.

The key is to select a dog food that has at least two animal proteins in the first three ingredients.