Sentences with phrase «first knockout mice»

This led him to undertake a series of studies beginning in 1977 that demonstrated gene targeting in animal cells and culminated in the construction of one of the first knockout mice in 1989.

The first knockout mice constructed by gene targeting were published in 1989, and the rest is history.

Not exact matches

As expected, gp96 knockout mice grew normally at first.

These genetic modification techniques debuted in the 1980s, but the first autism knockout mice took a while longer to develop, emerging only in the early 2000s.

In fact, whereas 74 percent of the control mice committed infanticide after the birth of their first litter, none of the knockout mice killed their offspring.

The first group was mice with targeted deletion of the interleukin 10 (IL10) gene, known as interleukin 10 knockout (IL10 - / --RRB- mice, which develop colitis through T helper immune cells.

As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.

Some mouse strains are only archived as knockout - first allele («tm1a allele»), but if users are interested in another allele which is not cryopreserved at EMMA, some EMMA nodes offer allele conversion as a service.

The mouse clinics participating in INFRAFRONTIER all contributed to major European phenotyping projects such as the European Mouse Disease Clinic (EUMODIC) project, the first internationally coordinated large scale phenotyping effort, which produced and phenotyped 500 IKMC knockout mouse lmouse clinics participating in INFRAFRONTIER all contributed to major European phenotyping projects such as the European Mouse Disease Clinic (EUMODIC) project, the first internationally coordinated large scale phenotyping effort, which produced and phenotyped 500 IKMC knockout mouse lMouse Disease Clinic (EUMODIC) project, the first internationally coordinated large scale phenotyping effort, which produced and phenotyped 500 IKMC knockout mouse lmouse lines.

In the first year of the contract, NIH will expend about $ 10 million to acquire about 250 lines of knockout mice.

First cloning of the gene for prion protein (PrP), demonstration that PrP knockout mice are resistant to prion disease and that PrP antibodies abrogate prions in infected cells.

That would amplify a trend that began about 15 years ago when knockout mice first became common.

The first was the comparison of mice with TERT knockout and haploinsufficiency, to mice haploinsufficient and deficient in mTR, the murine TERC.