Sentences with phrase «first line treatment with»

Selective serotonin reuptake inhibitors (SSRIs) as first line treatment for depression were more cost effective than tricyclic antidepressants (TCAs) alone, but less cost effective than TCAs as first line treatment with SSRIs for dropouts.

It is the first time a therapy has improved progression - free survival over the current standard first line treatment with platinum - based doublet chemotherapy.»

Not exact matches

An important trigger this year will be the outcome of a study where Darzalex is being tested as first - line treatment in combination with Celgene Corp's Revlimid.

As with any non-traumatic knee injury, if your physician suspects you have plica syndrome the first line of treatment is rest, activity modification, anti-inflammatory medications, and physical therapy to decrease inflammation around the plica.

The first - line treatment for the majority of separation anxiety cases is psychotherapy; cognitive behavioral therapy in particular is used with great success on mild to moderate cases.

The first line of treatment, when needed, is with prescription oral antifungal lozenges, suspensions, or mouthwashes.

Supporting commercial lines businesses Progress on fixed fees for costs of noise - induced hearing loss claims Support for fair compensation for mesothelioma sufferers Expansion of the Insurance Fraud Bureau's scope to commercial liability Campaigning for solutions fit for our future Our Flood Free Homes campaign Forward thinking policy for data and cyber Engaging Government to support the role of income protection Delivery of Flood Re, a world first solution for affordable flood cover Fighting fraud Partnering with Government on the Insurance Fraud Taskforce Renewing the Insurance Fraud Enforcement Department Securing new insurer access to the DVLA registered owners database Influencing sensible regulation On Solvency II, we: Secured changes to secondary legislation Clarified treatment of deferred tax Negotiated a favourable calibration of the EIOPA's fundamental spread Supporting insurance businesses Pushing for sensible development of global capital standards Securing better targeted tax legislation Managing the impact of international financial reporting standards.

The results from the Cancer Research UK - funded STAMPEDE trial could change the standard of care for men with prostate cancer, making abiraterone a first - line treatment alongside hormone therapy.

While clomiphene is a first - line treatment used to induce ovulation in women with PCOS, it has downsides — namely that in a significant number of women it does not lead to improved ovulation or live births, and if it does induce ovulation, it frequently results in pregnancies with multiples who face much higher negative outcomes including death.

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.

Ozanimod is a novel, oral, selective sphingosine 1 - phosphate 1 (S1PR1) and 5 (S1PR5) receptor modulator, and was compared to the first - line treatment, Avonex ® (interferon beta - 1a)(IFN), in patients with relapsing multiple sclerosis (RMS).

Demand for this plant - based version of the drug has been high since 2005 when the World Health Organization officially recommended it, combined with other anti-malarial drugs, as a first - line treatment for malaria.

«However, we believe our study findings, in combination with the previous literature and our clinical experience, are sufficient to support catheter ablation as first - line treatment for AFL,» Marcus said.

«All endpoints of efficacy and tolerability favoured treatment with pembrolizumab, suggesting it should become one standard of care for first line treatment of patients with advanced NSCLC and high PD - L1 expression.

The treatment arm received palbociclib together with standard of care for this population, fulvestrant, a drug that blocks the hormone receptor via a different mechanism than first - line therapies.

Pembrolizumab is set to become a new option for first line treatment of patients with advanced lung cancer and high PD - L1 expression, according to the results of the phase III KEYNOTE - 024 trial presented at the ESMO 2016 Congress in Copenhagen and published in the New England Journal of Medicine.

The drug was approved by the FDA as a combination first - line therapy for postmenopausal women with ER + / HER2 - breast cancer, as initial endocrine - based treatment for their metastatic disease.

BRAF mutations, which occur in about 40 to 50 percent of these patients, have been associated with aggressive tumors and decreased ability of tumors to respond to radioactive iodine, typically the first line of treatment in these patients.

The blockbuster drug Herceptin is a first - line treatment for many women with HER2 - positive breast cancer, but in most cases, resistance to the treatment develops within a year.

Carlos A. Morillo, M.D., F.R.C.P.C., of McMaster University, Hamilton, Canada, and colleagues compared ablation to drug treatment as first - line therapy in patients with paroxysmal AF who had not previously received treatment.

Now, the researchers will replicate their findings in a larger sample of MS patients, and treat those patients diagnosed with obstructive sleep apnea with positive airway pressure therapy (CPAP), the first - line treatment for OSA.

«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»

«With a key challenge being that resistance to drugs is spreading faster than new drugs are being developed and approved,» they suggest that «the use of encapsulated, nanobody - targeted drugs as described here has the potential to reverse resistance to many first - line treatments.»

«The prescription of lithium has decreased steadily in recent years, but our results show that lithium should remain the first line of treatment for patients with bipolar disorder.

«Because PGAs are a first line of treatment for glaucoma, these results provide physicians with one reason to reconsider when they should be added in new patients, particularly those where the aim is to prevent glaucoma such as in ocular hypertension patients or glaucoma suspects,» Dr. Pasquale said.

It is estimated that up to 10,000 Australians with severe depression and who have not responded to first line treatments, such as medication, could benefit from the new treatment.

Therefore, it may benefit patients both as a first - line and second - or later - line treatment, by producing a durable clinical benefit and with a reduced toxicity profile compared to current EGFR inhibitor therapies.

Brain scans of war veterans with posttraumatic stress disorder have led researchers to an area of the prefrontal cortex that appears to be a good predictor of response to treatment with SSRIs — the first - line drug treatment for PTSD.

IUI with ovarian stimulation is in many countries first - line fertility treatment for couples with unexplained and mild male infertility.

According to Dr. Hsu, nonsurgical therapy should be the first - line treatment in all athletes with lower back conditions because successful recovery rates from rehabilitation protocols are high.

Though behavioral parent training is known to have positive results for children with ADHD, fewer parents and mental health and medical practitioners know about it than medication prescribed for ADHD, which can come with side effects and is not recommended as a first - line treatment for preschool - age children, DuPaul said.

Researchers explained that this difference may be due, in part, to a selection bias where healthier patients were treated with surgery, and they underscored the need for a controlled clinical trial with matched patients receiving each treatment first - line to compare the efficacy of these therapies.

A Phase 3 Open - Label Randomized Study of Quizartinib (AC220) Monotherapy Versus Salvage Chemotherapy in Subjects with FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidawith FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) ConsolidaWith or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidation

Patients with stage 2, 3, and 4 ovarian cancer who are in complete remission after first - line treatment;

• Subject has received prior treatment with ASP2215 or other FLT3 inhibitors (with the exception of sorafenib and midostaurin used in first - line therapy regimen as part of induction, consolidation, and / or maintenance).

Some patients are resistant to treatment with the anti-anxiety drug diazepam (Valium), a standard first - line treatment for such poisoning, and its effectiveness decreases the longer the seizure lasts.

Tanyi said he is eager to explore whether the dendritic - cell vaccine might also be used as a first - line treatment for women who are newly diagnosed with ovarian cancer.

Subject must have achieved a CR / CRi / CRp (criteria as defined by [Cheson et al, 2003], see Section 5.3) with first line treatment and has hematologic relapse.

Chi's presentation focused on first - line treatment outcomes and correlations with deep targeted sequencing of circulating tumor (ctDNA) that occurred at baseline.

To investigate changes in the cerebrospinal fluid (CSF) immunological profile after treatment switch from first - line injectables to rituximab in patients with relapsing - remitting MS (RRMS), and to compare the profile in MS patients with healthy controls (HC).

The 10 - year survival rate in subjects receiving first - line treatment with imatinib ranged from 64.4 % to 84.4 %.

Recent FDA approval of front - line brentuximab vedotin with chemotherapy in patients with stage III / IV Hodgkin lymphoma offers the first new treatment for this disease in over 40 years.

Based primarily on clinical trials led by Arjun V. Balar, MD, assistant professor of medicine and director of the Genitourinary Medical Oncology Program, the FDA approved atezolizumab (Tecentriq ®) and pembrolizumab (Keytruda ®) as first - line treatments for these particularly frail patients with advanced bladder cancer in early 2017.

Led by Leena Gandhi, MD, PhD, associate professor of medicine and director of thoracic medical oncology, researchers from the KEYNOTE - 021 study demonstrated for the first time that combining an immune checkpoint inhibitor — in this case, pembrolizumab — with a platinum - doublet chemotherapy regimen might be more effective than chemotherapy alone as first - line treatment for advanced, non-squamous NSCLC.

While several viable treatment options for prostate cancer exist, many men affected with prostate cancer will not respond to first - line treatments.

«As a result, now when most patients are identified for the first time with leakage in the center of their retina with associated loss of vision, the first line of treatment is a VEGF inhibitor therapy,» he said.

Patients treated with immunotherapy first still derived some benefit from BRAF - inhibitor treatment in the second - line setting.

Pertuzumab was approved by the FDA in 2012 for first - line treatment of HER2 + metastatic breast cancer in combination with trastuzumab and the chemotherapy docetaxel (Taxotere).

Botox is sometimes recommended for people with enlarged muscles in the area that are causing them pain, or for someone who also has chronic headaches; but Dr. Bakhtiari notes that it has side effects and shouldn't be a first - line treatment.

While researchers don't recommend omega - 3s as a first - line treatment for anyone with major depression or bipolar disorder, emerging research suggests it may be effective for people with mild depression or as an adjuvant to medication.