Not exact matches
«This is the
first study to show that a
systemic therapy provides significant clinical benefit in a randomized fashion to advanced uveal melanoma patients, who have very limited
treatment options,» said Richard D. Carvajal, MD, a medical oncologist at Memorial Sloan - Kettering and lead author on the study.
The researchers found that the addition of vitamin D3 to ciclesonide did not significantly reduce the rate of
first treatment failure (a composite outcome of decline in lung function and increases in use of beta - agonists,
systemic steroids, and health care utilization) compared with placebo; 28 percent and 29 percent of participants in each group, respectively, experienced at least 1
treatment failure during 28 weeks.
«Our research shows that combination
treatment with the two compounds can promote resilience against stress - mediated depression - like phenotypes by modulating
systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,» says Jun Wang, PhD, Associate Professor of the Department of Neurology and
first author on the paper.
Last year the Food and Drug Administration approved Benlysta (belimumab), the
first new
treatment for
systemic lupus erythematosus in more than 50 years, and Yervoy (ipilimumab), the
first drug shown to prolong the lives of patients with melanoma.
In a study involving 12 patients with bladder cancer, who also underwent prostate surgery as part of their
treatment, she identified the ICOS molecule as the
first immunologic marker identified in both tumor tissues and the
systemic circulation that can be used as a biomarker for monitoring of anti-CTLA-4 treated patients as a possible marker of therapeutic activity.
Preliminary analyses of the results of the
first combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional therapies will find application — as
treatment for patients who can not tolerate
systemic immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.
With harsher
systemic punishment doled out in our most vulnerable places, we need to recognize that classrooms are often the
first place where students see inequity, and it's usually not in the resources but in their
treatment.