Sentences with phrase «first targeted therapies»

«These are optimistic results for one of the first targeted therapies for cancer stem cells,» says Antonio Jimeno, MD, PhD, investigator at the CU Cancer Center, director of the university's Cancer Stem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center site.

As the first targeted therapies edge towards regulatory approval, attention turns to the next drugs in line.

Dr. Eduardo Méndez has received a five - year, $ 2.2 million grant from the National Institutes of Health to develop the first targeted therapy that they hope will be effective for most patients with head and neck cancers.

Not exact matches

Luxturna is the first of a crop of treatments that target diseases caused by mutations in specific genes, and thus is referred to by many as the first gene therapy in the U.S.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

Its first indication is a rare cancer that affects only 3,100 new patients each year, and the drug only targets roughly 30 % of those patients who do not respond to standard therapy.

«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.

«This is a first step,» he says, because it provides a target for therapy: somehow stimulating the SVZ to start replenishing the pool of cells that give rise to the vulnerable, depleted interneurons in CHD.

Therapies that target some of these trunk mutations already exist, and they often produce dramatic responses at first.

The researchers, at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, say their test is the first developed for a precision prostate cancer therapy targeted at specific genetic faults within tumours.

Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.

«Disrupting this circuit by targeting any of its individual components blocks the expression of these transcription factors and significantly impairs therapy - resistant prostate cancer,» said TSRI Research Associate Ji - Hak Jeong, the first author of the study.

Ben Stanger, MD, PhD, a professor in the division of Gastroenterology, and first author Ravi Maddipati, MD, an instructor in the division of Gastroenterology, say that these results may prove useful in designing better targeted therapies to stop tumor progression and provide an improved non-invasive method for detecting early disease states in this highly lethal cancer.

Fossel believes the first viable antiaging therapy will target telomeres, which are repeating DNA sequences at the ends of chromosomes.

«Investigating these pathways may identify other targets for therapy or other markers that predict treatment response,» says first author Theresa Wampler Muskardin, M.D., a rheumatologist at Mayo Clinic in Rochester, Minn. «It will help rheumatologists find the right drug for each patient and spare patients medications that won't work for them.»

Understanding the molecular mechanisms underlying Aurora kinase - overexpressing tumours will help in the design of targeted and personalised cancer therapy,» said Dr Linda Chuang, Senior Research Scientist at CSI Singapore, who is the first author of the study.

Luxturna is the first gene therapy approved in the U.S. that targets a disease caused by mutations in a specific gene.

The next step in the research should be to study the use of mindfulness - based therapies to target purpose in life and resulting sleep quality, said Arlener Turner, the study's first author and a former postdoctoral fellow in neurology at Feinberg.

In a new study, researchers for the first time have identified a possible target for a new CNS - PNET therapy.

The authors say «We have provided the first evidence that two brief psychological therapies targeting the two leading mental health related causes of the global burden of disease, delivered by the same lay counsellor in routine primary care, to patients who had never received such therapies before, can lead to sustained improvements in health over one year, and that the investments made in providing this intervention is excellent value for money.

Recognizing this fear and targeting it with therapy may be a critical first step before other mental illnesses can be treated.

The studies present the first genetic evidence of a link between cholesterol and the disease, and they may lead scientists to identify new targets for therapy.

These therapies, the first an antibody and the second of a class called tyrosine kinase inhibitors (TKIs), reduce the ability of a target gene to manufacture the protein it encodes.

In their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patients.

Their surprising discovery demonstrates that the vitamin A derivative ATRA (all - trans retinoic acid), a treatment for APL that is considered to be the first example of modern targeted cancer therapy, can block multiple cancer - driving pathways and, at the same time, eliminate cancer stem cells by degrading the Pin1 enzyme.

The first successful targeted human gene therapy was reported in 2000.

For their contribution to the development of the breast cancer therapy Herceptin, the first target - directed cancer treatment for solid tumors.

Learn about the process behind Penn's CAR - T cell therapy, the first - ever cancer treatment that genetically alters a patient's own immune cells to target and destroy cancer cells.

Dingledine identified two take - home messages from the paper: First, COX - 2 itself is probably not a good target for antiepileptic therapy, and it may be better to go downstream, to prostaglandin receptors like EP2.

Our recently announced investment in Acerta Pharma also adds the potentially transformational BTK inhibitor class of treatments to our portfolio, subject to closure in the first quarter of 2016, strengthening further our focus on targeted therapies.

In an editorial published with the study, Viktor Grunwald, of Hannover Medical School, Germany, wrote «these antitumour activity findings indicate the potential clinical benefit of targeted - immune combinations and suggest that further studies are warranted to explore whether a first - line targeted - immune combination might overcome the standard of sequential targeted and immune therapies.»

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September 1, 1997 Targeting gene therapy to specific cells Researchers at the University of Chicago Medical Center have developed the first practical method to restrict the activity of genes used for gene therapy to a specific cell type.

The company's lead candidate, GLN - 1001, is a first - in - class, orally available oncolytic small molecule, currently being developed as a potentially disease modifying therapy for glioblastoma by targeting specific vulnerabilities in tumor cells.

Advanced Cancers Destined to Return After Single Drug Therapies Targeted cancer cell therapies using man - made proteins dramatically shrink many tumors in the first few months of treatment, but new research from Johns Hopkins scientists finds why the cells all too often become resistant, the treatment stops working, and the diseaseTherapies Targeted cancer cell therapies using man - made proteins dramatically shrink many tumors in the first few months of treatment, but new research from Johns Hopkins scientists finds why the cells all too often become resistant, the treatment stops working, and the diseasetherapies using man - made proteins dramatically shrink many tumors in the first few months of treatment, but new research from Johns Hopkins scientists finds why the cells all too often become resistant, the treatment stops working, and the disease returns.

The technology, demonstrated for the first time in mice, one day may be used to treat pain, depression, epilepsy and other neurological disorders in people by targeting therapies to specific brain circuits.

SMNRx is the first therapy that specifically targets the underlying splicing defect behind SMA to be tested in children with the disease.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

In the recent past, IL - 2 was the most common first - line therapy for advanced kidney cancer, but because it can have serious side effects many doctors now only use it for cancers that are not responding to targeted therapies.

It also includes Charles Sawyers, who was a key contributor to the development of one of the first successful targeted molecular therapies for cancer.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

«This is the first molecular - targeted and first anti-angiogenesis therapy to demonstrate benefit in this population and, combined with chemotherapy followed by [Avastin] maintenance, should be considered as one standard option for women with this disease,» said lead researcher Dr. Robert A. Burger, director of the Women's Cancer Center at Fox Chase Cancer Center in Philadelphia.

In this regard, Roberts indicates that «In 2005, the U.S. Food and Drug Administration approved the first race - specific drug, a heart failure therapy that was targeted to black patients for marketing reasons.»

To create an effective mAb therapy, you first have to determine the specific target (s) of most relevance to the disease process.

Interacting with others in group therapy will help the therapist to see first - hand how a client interacts with others and behaves in a social situation, allowing the therapist to provide targeted feedback and suggestions to each client (Cherry, 2017).

The intervention group received usual care plus 5 sessions of cognitive behavioural therapy during the first 12 weeks and further targeted cognitive behavioural therapy (2 to 3 sessions per week) if early signs of relapse were present (e.g. racing thoughts, suspiciousness; assessed by fortnightly questionnaires or by the treatment team).