Sentences with phrase «first tumor suppressor gene»
His lab discovered the first oncogene in 1982 and the first tumor suppressor gene in 1986.
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BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.
The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor - suppressor genes and genes that can be inhibited with drugs, sometimes called «druggable» targets.
Since 1971, the standard tumor suppressor model has held that cancer is caused by a «two - hit» cascade in which first one copy and then the second copy of a gene becomes mutated.
Researchers have found the first connection between the loss of a tumor suppressor gene and activation of a cancer - promoting oncogene, a scenario thought to be prevalent in the initiation of many...
Knudson's revolutionary two - hit theory of cancer formation enabled me to discover the first imprinted tumor suppressor gene, the Insulin like Growth Factor 2 Receptor (IGF2R), propelling me into the field of epigenetics.