Sentences with phrase «first tyrosine kinase»
Hunter's breakthrough, which set the story in motion, was a product of basic research on a chicken RNA tumor virus: the 1979 discovery of the first tyrosine kinase paved the way for our understanding of how cells perceive their environment and respond appropriately to growth signals.
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These therapies, the first an antibody and the second of a class called tyrosine kinase inhibitors (TKIs), reduce the ability of a target gene to manufacture the protein it encodes.
Larry Samelson provides the first demonstration that the TCR is coupled to tyrosine kinase pathways, now known to be true for all immunoreceptors.
The researchers first identified the kinase domains of 138 tyrosine kinases and similar enzymes from the kinome database.
In this first - of - a-kind survey, researchers used a forward - looking approach to screen the genes that produce tyrosine kinases — reasoning that somewhere in this genomic landscape they might encounter novel mutations that spur colon cancer and other types of cancer.